| Name |
Primary Malignancy of Oesophageal (pri_oesoph) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
0ded7ffa-a2a9-4c5f-a718-586f32da756e |
| Definition |
A gastrointestinal system cancer that is located_in the esophagus. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1809 |
| Female (%) |
484 (27%) |
| Male (%) |
1325 (73%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
2.36 (1.32,3.39) |
| Male |
9.8 (7.5,12.09) |
Incidence stratified by sex
| Female |
0.91 (0.67,1.16) |
| Male |
3.31 (2.79,3.82) |
Incidence stratified by age
| Ages 40-44 |
0.3 (-0.04,0.64) |
| Ages 45-49 |
0.37 (0.05,0.7) |
| Ages 50-54 |
0.89 (0.42,1.35) |
| Ages 55-59 |
1.82 (1.22,2.42) |
| Ages 60-64 |
2.11 (1.55,2.67) |
| Ages 65-69 |
4.88 (3.91,5.85) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
2 (1,4) |
10 (8,13) |
24 (21,28) |
| CALIBER |
3 (2,3) |
13 (12,14) |
30 (28,32) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
3(0,10) |
5(2,10) |
24(17,32) |
| Low |
2(0,9) |
11(6,18) |
24(18,33) |
| Medium |
0(NaN,NaN) |
15(9,24) |
19(13,27) |
| High |
2(0,7) |
5(2,10) |
27(20,37) |
| Most deprived |
3(1,9) |
16(10,25) |
29(21,39) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
2(1,4) |
11(8,14) |
25(22,29) |
| Scotland |
5(1,17) |
6(2,14) |
20(13,31) |
| Wales |
0(NaN,NaN) |
12(5,27) |
23(13,37) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153944, Events=165
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.93 (0.64, 1.33) |
0.683 |
| BMI |
obese |
0.99 (0.66, 1.49) |
0.954 |
| BMI |
underweight |
0 (0, Inf) |
0.994 |
| smoking |
previous |
1.57 (1.13, 2.18) |
0.00649 |
| smoking |
current |
1.16 (0.66, 2.02) |
0.611 |
| hypertension |
yes |
0.69 (0.47, 1.01) |
0.0533 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20001 |
Cancer code, self-reported |
1017 |
oesophageal cancer |
| 41202 |
Diagnoses - main ICD10 |
C15 |
Malignant neoplasm of oesophagus |
| 41204 |
Diagnoses - secondary ICD10 |
C15 |
Malignant neoplasm of oesophagus |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C15 |
Malignant neoplasm of oesophagus |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C15 |
Malignant neoplasm of oesophagus |
| 42040 |
GP clinical event records |
B100.00 |
Malignant neoplasm of cervical oesophagus |
| 42040 |
GP clinical event records |
B101.00 |
Malignant neoplasm of thoracic oesophagus |
| 42040 |
GP clinical event records |
B102.00 |
Malignant neoplasm of abdominal oesophagus |
| 42040 |
GP clinical event records |
B103.00 |
Malignant neoplasm of upper third of oesophagus |
| 42040 |
GP clinical event records |
B104.00 |
Malignant neoplasm of middle third of oesophagus |
| 42040 |
GP clinical event records |
B105.00 |
Malignant neoplasm of lower third of oesophagus |
| 42040 |
GP clinical event records |
B106.00 |
Malignant neoplasm, overlapping lesion of oesophagus |
| 42040 |
GP clinical event records |
B107.00 |
Siewert type I adenocarcinoma |
| 42040 |
GP clinical event records |
B10..00 |
Malignant neoplasm of oesophagus |
| 42040 |
GP clinical event records |
B10y.00 |
Malignant neoplasm of other specified part of oesophagus |
| 42040 |
GP clinical event records |
B10z.00 |
Malignant neoplasm of oesophagus NOS |
| 42040 |
GP clinical event records |
B10z.11 |
Oesophageal cancer |
| 42040 |
GP clinical event records |
ZV10016 |
[V]Personal history of malignant neoplasm of oesophagus |
| 42040 |
GP clinical event records |
XE1vQ |
Malignant neoplasm of oesophagus NOS |
| 42040 |
GP clinical event records |
XaOrV |
Siewert type I adenocarcinoma |
| 40006 |
Type of cancer: ICD10 |
C15 |
Malignant neoplasm of oesophagus |