Metadata

Name Primary Malignancy of Oro-pharyngeal (pri_oroph)
Category Cancers
Sex
Adult Yes
UUID 8229802a-890a-4683-96a1-d0bb1fc96f0d
Definition Malignant neoplasm of lip, oral cavity and pharynx.

Ontologies

Disease Ontology (DOID) DOID_60119
GWAS Catalogue EFO_0005577
MeSH D010610
SNOMED-CT 363507003
FinnGen C3_LIP_ORAL_PHARYNX

Key Summary Statistics

Cases from any source

Total 2467
Female (%) 878 (36%)
Male (%) 1589 (64%)

Year first recorded

pri_oroph year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced pri_oroph cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of pri_oroph

Baseline prevalence stratified by sex

Female 15.44 (12.8,18.08)
Male 30.24 (26.21,34.27)

Incidence stratified by sex

Female 1.39 (1.08,1.7)
Male 2.89 (2.41,3.38)

Incidence stratified by age

Ages 40-44 0.5 (0.06,0.94)
Ages 45-49 1.86 (1.13,2.58)
Ages 50-54 1.33 (0.76,1.9)
Ages 55-59 2.4 (1.7,3.09)
Ages 60-64 2.46 (1.86,3.07)
Ages 65-69 2.77 (2.04,3.5)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB pri_oroph prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 14 (10,18) 26 (22,30) 35 (31,39)
CALIBER 11 (10,12) 27 (25,28) 38 (36,40)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 13(6,24) 16(10,25) 27(20,36)
Low 14(6,26) 22(14,32) 34(26,43)
Medium 14(7,26) 26(18,36) 33(26,43)
High 12(6,22) 27(19,38) 34(26,44)
Most deprived 16(9,25) 38(28,50) 48(37,60)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 13(10,18) 22(18,27) 33(29,37)
Scotland 23(11,41) 44(31,61) 46(34,61)
Wales 4(0,21) 36(21,57) 42(28,61)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153944, Events=165

Factor Level Hazard Ratio P value
BMI overweight 0.93 (0.64, 1.33) 0.683
BMI obese 0.99 (0.66, 1.49) 0.954
BMI underweight 0 (0, Inf) 0.994
smoking previous 1.57 (1.13, 2.18) 0.00649
smoking current 1.16 (0.66, 2.02) 0.611
hypertension yes 0.69 (0.47, 1.01) 0.0533

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20001 Cancer code, self-reported 1079 oropharynx / oropharyngeal cancer
20001 Cancer code, self-reported 1004 cancer of lip/mouth/pharynx/oral cavity
20001 Cancer code, self-reported 1010 lip cancer
20001 Cancer code, self-reported 1078 tonsil cancer
20001 Cancer code, self-reported 1077 mouth cancer
20001 Cancer code, self-reported 1011 tongue cancer
20001 Cancer code, self-reported 1006 larynx/throat cancer
20001 Cancer code, self-reported 1012 gum cancer
20001 Cancer code, self-reported 1015 parotid gland cancer
20001 Cancer code, self-reported 1016 other salivary gland cancer
41202 Diagnoses - main ICD10 C00 Malignant neoplasm of lip
41202 Diagnoses - main ICD10 C01 Malignant neoplasm of base of tongue
41202 Diagnoses - main ICD10 C02 Malignant neoplasm of other and unspecified parts of tongue
41202 Diagnoses - main ICD10 C03 Malignant neoplasm of gum
41202 Diagnoses - main ICD10 C04 Malignant neoplasm of floor of mouth
41202 Diagnoses - main ICD10 C05 Malignant neoplasm of palate
41202 Diagnoses - main ICD10 C06 Malignant neoplasm of other and unspecified parts of mouth
41202 Diagnoses - main ICD10 C07 Malignant neoplasm of parotid gland
41202 Diagnoses - main ICD10 C08 Malignant neoplasm of other and unspecified major salivary glands
41202 Diagnoses - main ICD10 C09 Malignant neoplasm of tonsil
41202 Diagnoses - main ICD10 C10 Malignant neoplasm of oropharynx
41202 Diagnoses - main ICD10 C11 Malignant neoplasm of nasopharynx
41202 Diagnoses - main ICD10 C12 Malignant neoplasm of piriform sinus
41202 Diagnoses - main ICD10 C13 Malignant neoplasm of hypopharynx
41202 Diagnoses - main ICD10 C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
41204 Diagnoses - secondary ICD10 C00 Malignant neoplasm of lip
41204 Diagnoses - secondary ICD10 C01 Malignant neoplasm of base of tongue
41204 Diagnoses - secondary ICD10 C02 Malignant neoplasm of other and unspecified parts of tongue
41204 Diagnoses - secondary ICD10 C03 Malignant neoplasm of gum
41204 Diagnoses - secondary ICD10 C04 Malignant neoplasm of floor of mouth
41204 Diagnoses - secondary ICD10 C05 Malignant neoplasm of palate
41204 Diagnoses - secondary ICD10 C06 Malignant neoplasm of other and unspecified parts of mouth
41204 Diagnoses - secondary ICD10 C07 Malignant neoplasm of parotid gland
41204 Diagnoses - secondary ICD10 C08 Malignant neoplasm of other and unspecified major salivary glands
41204 Diagnoses - secondary ICD10 C09 Malignant neoplasm of tonsil
41204 Diagnoses - secondary ICD10 C10 Malignant neoplasm of oropharynx
41204 Diagnoses - secondary ICD10 C11 Malignant neoplasm of nasopharynx
41204 Diagnoses - secondary ICD10 C12 Malignant neoplasm of piriform sinus
41204 Diagnoses - secondary ICD10 C13 Malignant neoplasm of hypopharynx
41204 Diagnoses - secondary ICD10 C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
40001 Underlying (primary) cause of death: ICD10 C00 Malignant neoplasm of lip
40001 Underlying (primary) cause of death: ICD10 C01 Malignant neoplasm of base of tongue
40001 Underlying (primary) cause of death: ICD10 C02 Malignant neoplasm of other and unspecified parts of tongue
40001 Underlying (primary) cause of death: ICD10 C03 Malignant neoplasm of gum
40001 Underlying (primary) cause of death: ICD10 C04 Malignant neoplasm of floor of mouth
40001 Underlying (primary) cause of death: ICD10 C05 Malignant neoplasm of palate
40001 Underlying (primary) cause of death: ICD10 C06 Malignant neoplasm of other and unspecified parts of mouth
40001 Underlying (primary) cause of death: ICD10 C07 Malignant neoplasm of parotid gland
40001 Underlying (primary) cause of death: ICD10 C08 Malignant neoplasm of other and unspecified major salivary glands
40001 Underlying (primary) cause of death: ICD10 C09 Malignant neoplasm of tonsil
40001 Underlying (primary) cause of death: ICD10 C10 Malignant neoplasm of oropharynx
40001 Underlying (primary) cause of death: ICD10 C11 Malignant neoplasm of nasopharynx
40001 Underlying (primary) cause of death: ICD10 C12 Malignant neoplasm of piriform sinus
40001 Underlying (primary) cause of death: ICD10 C13 Malignant neoplasm of hypopharynx
40001 Underlying (primary) cause of death: ICD10 C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
40002 Contributory (secondary) causes of death: ICD10 C00 Malignant neoplasm of lip
40002 Contributory (secondary) causes of death: ICD10 C01 Malignant neoplasm of base of tongue
40002 Contributory (secondary) causes of death: ICD10 C02 Malignant neoplasm of other and unspecified parts of tongue
40002 Contributory (secondary) causes of death: ICD10 C03 Malignant neoplasm of gum
40002 Contributory (secondary) causes of death: ICD10 C04 Malignant neoplasm of floor of mouth
40002 Contributory (secondary) causes of death: ICD10 C05 Malignant neoplasm of palate
40002 Contributory (secondary) causes of death: ICD10 C06 Malignant neoplasm of other and unspecified parts of mouth
40002 Contributory (secondary) causes of death: ICD10 C07 Malignant neoplasm of parotid gland
40002 Contributory (secondary) causes of death: ICD10 C08 Malignant neoplasm of other and unspecified major salivary glands
40002 Contributory (secondary) causes of death: ICD10 C09 Malignant neoplasm of tonsil
40002 Contributory (secondary) causes of death: ICD10 C10 Malignant neoplasm of oropharynx
40002 Contributory (secondary) causes of death: ICD10 C11 Malignant neoplasm of nasopharynx
40002 Contributory (secondary) causes of death: ICD10 C12 Malignant neoplasm of piriform sinus
40002 Contributory (secondary) causes of death: ICD10 C13 Malignant neoplasm of hypopharynx
40002 Contributory (secondary) causes of death: ICD10 C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
42040 GP clinical event records B000000 Malignant neoplasm of upper lip, external
42040 GP clinical event records B000100 Malignant neoplasm of upper lip, lipstick area
42040 GP clinical event records B000.00 Malignant neoplasm of upper lip, vermilion border
42040 GP clinical event records B000z00 Malignant neoplasm of upper lip, vermilion border NOS
42040 GP clinical event records B001000 Malignant neoplasm of lower lip, external
42040 GP clinical event records B001100 Malignant neoplasm of lower lip, lipstick area
42040 GP clinical event records B001.00 Malignant neoplasm of lower lip, vermilion border
42040 GP clinical event records B001z00 Malignant neoplasm of lower lip, vermilion border NOS
42040 GP clinical event records B002100 Malignant neoplasm of upper lip, frenulum
42040 GP clinical event records B002200 Malignant neoplasm of upper lip, mucosa
42040 GP clinical event records B002300 Malignant neoplasm of upper lip, oral aspect
42040 GP clinical event records B002.00 Malignant neoplasm of upper lip, inner aspect
42040 GP clinical event records B002z00 Malignant neoplasm of upper lip, inner aspect NOS
42040 GP clinical event records B003000 Malignant neoplasm of lower lip, buccal aspect
42040 GP clinical event records B003100 Malignant neoplasm of lower lip, frenulum
42040 GP clinical event records B003200 Malignant neoplasm of lower lip, mucosa
42040 GP clinical event records B003300 Malignant neoplasm of lower lip, oral aspect
42040 GP clinical event records B003.00 Malignant neoplasm of lower lip, inner aspect
42040 GP clinical event records B003z00 Malignant neoplasm of lower lip, inner aspect NOS
42040 GP clinical event records B004000 Malignant neoplasm of lip unspecified, buccal aspect
42040 GP clinical event records B004200 Malignant neoplasm of lip unspecified, mucosa
42040 GP clinical event records B004300 Malignant neoplasm of lip, oral aspect
42040 GP clinical event records B004.00 Malignant neoplasm of lip unspecified, inner aspect
42040 GP clinical event records B005.00 Malignant neoplasm of commissure of lip
42040 GP clinical event records B006.00 Malignant neoplasm of overlapping lesion of lip
42040 GP clinical event records B007.00 Malignant neoplasm of lip, unspecified
42040 GP clinical event records B00..00 Malignant neoplasm of lip
42040 GP clinical event records B00..11 Carcinoma of lip
42040 GP clinical event records B00z000 Malignant neoplasm of lip, unspecified, external
42040 GP clinical event records B00z100 Malignant neoplasm of lip, unspecified, lipstick area
42040 GP clinical event records B00zz00 Malignant neoplasm of lip, vermilion border NOS
42040 GP clinical event records B010000 Malignant neoplasm of base of tongue dorsal surface
42040 GP clinical event records B010.00 Malignant neoplasm of base of tongue
42040 GP clinical event records B010.11 Malignant neoplasm of posterior third of tongue
42040 GP clinical event records B010z00 Malignant neoplasm of fixed part of tongue NOS
42040 GP clinical event records B011100 Malignant neoplasm of midline of tongue
42040 GP clinical event records B011.00 Malignant neoplasm of dorsal surface of tongue
42040 GP clinical event records B011z00 Malignant neoplasm of dorsum of tongue NOS
42040 GP clinical event records B012.00 Malignant neoplasm of tongue, tip and lateral border
42040 GP clinical event records B013000 Malignant neoplasm of anterior 2/3 of tongue ventral surface
42040 GP clinical event records B013100 Malignant neoplasm of frenulum linguae
42040 GP clinical event records B013.00 Malignant neoplasm of ventral surface of tongue
42040 GP clinical event records B013z00 Malignant neoplasm of ventral tongue surface NOS
42040 GP clinical event records B014.00 Malignant neoplasm of anterior 2/3 of tongue unspecified
42040 GP clinical event records B015.00 Malignant neoplasm of tongue, junctional zone
42040 GP clinical event records B016.00 Malignant neoplasm of lingual tonsil
42040 GP clinical event records B017.00 Malignant overlapping lesion of tongue
42040 GP clinical event records B01..00 Malignant neoplasm of tongue
42040 GP clinical event records B01y.00 Malignant neoplasm of other sites of tongue
42040 GP clinical event records B01z.00 Malignant neoplasm of tongue NOS
42040 GP clinical event records B020.00 Malignant neoplasm of parotid gland
42040 GP clinical event records B021.00 Malignant neoplasm of submandibular gland
42040 GP clinical event records B022.00 Malignant neoplasm of sublingual gland
42040 GP clinical event records B02..00 Malignant neoplasm of major salivary glands
42040 GP clinical event records B02y.00 Malignant neoplasm of other major salivary glands
42040 GP clinical event records B02z.00 Malignant neoplasm of major salivary gland NOS
42040 GP clinical event records B030.00 Malignant neoplasm of upper gum
42040 GP clinical event records B031.00 Malignant neoplasm of lower gum
42040 GP clinical event records B03..00 Malignant neoplasm of gum
42040 GP clinical event records B03y.00 Malignant neoplasm of other sites of gum
42040 GP clinical event records B03z.00 Malignant neoplasm of gum NOS
42040 GP clinical event records B040.00 Malignant neoplasm of anterior portion of floor of mouth
42040 GP clinical event records B041.00 Malignant neoplasm of lateral portion of floor of mouth
42040 GP clinical event records B042.00 Malignant neoplasm, overlapping lesion of floor of mouth
42040 GP clinical event records B04..00 Malignant neoplasm of floor of mouth
42040 GP clinical event records B04y.00 Malignant neoplasm of other sites of floor of mouth
42040 GP clinical event records B04z.00 Malignant neoplasm of floor of mouth NOS
42040 GP clinical event records B050.00 Malignant neoplasm of cheek mucosa
42040 GP clinical event records B050.11 Malignant neoplasm of buccal mucosa
42040 GP clinical event records B051000 Malignant neoplasm of upper buccal sulcus
42040 GP clinical event records B051100 Malignant neoplasm of lower buccal sulcus
42040 GP clinical event records B051.00 Malignant neoplasm of vestibule of mouth
42040 GP clinical event records B052.00 Malignant neoplasm of hard palate
42040 GP clinical event records B053.00 Malignant neoplasm of soft palate
42040 GP clinical event records B054.00 Malignant neoplasm of uvula
42040 GP clinical event records B055000 Malignant neoplasm of junction of hard and soft palate
42040 GP clinical event records B055100 Malignant neoplasm of roof of mouth
42040 GP clinical event records B055.00 Malignant neoplasm of palate unspecified
42040 GP clinical event records B055z00 Malignant neoplasm of palate NOS
42040 GP clinical event records B056.00 Malignant neoplasm of retromolar area
42040 GP clinical event records B05..00 Malignant neoplasm of other and unspecified parts of mouth
42040 GP clinical event records B05y.00 Malignant neoplasm of other specified mouth parts
42040 GP clinical event records B05z.00 Malignant neoplasm of mouth NOS
42040 GP clinical event records B060000 Malignant neoplasm of faucial tonsil
42040 GP clinical event records B060100 Malignant neoplasm of palatine tonsil
42040 GP clinical event records B060200 Malignant neoplasm of overlapping lesion of tonsil
42040 GP clinical event records B060.00 Malignant neoplasm of tonsil
42040 GP clinical event records B060z00 Malignant neoplasm tonsil NOS
42040 GP clinical event records B061.00 Malignant neoplasm of tonsillar fossa
42040 GP clinical event records B062000 Malignant neoplasm of faucial pillar
42040 GP clinical event records B062100 Malignant neoplasm of glossopalatine fold
42040 GP clinical event records B062200 Malignant neoplasm of palatoglossal arch
42040 GP clinical event records B062300 Malignant neoplasm of palatopharyngeal arch
42040 GP clinical event records B062.00 Malignant neoplasm of tonsillar pillar
42040 GP clinical event records B062z00 Malignant neoplasm of tonsillar fossa NOS
42040 GP clinical event records B063.00 Malignant neoplasm of vallecula
42040 GP clinical event records B064000 Malignant neoplasm of epiglottis, free border
42040 GP clinical event records B064100 Malignant neoplasm of glossoepiglottic fold
42040 GP clinical event records B064.00 Malignant neoplasm of anterior epiglottis
42040 GP clinical event records B064z00 Malignant neoplasm of anterior epiglottis NOS
42040 GP clinical event records B065.00 Malignant neoplasm of junctional region of epiglottis
42040 GP clinical event records B066.00 Malignant neoplasm of lateral wall of oropharynx
42040 GP clinical event records B067.00 Malignant neoplasm of posterior wall of oropharynx
42040 GP clinical event records B06..00 Malignant neoplasm of oropharynx
42040 GP clinical event records B06y.00 Malignant neoplasm of oropharynx, other specified sites
42040 GP clinical event records B06yz00 Malignant neoplasm of other specified site of oropharynx NOS
42040 GP clinical event records B06z.00 Malignant neoplasm of oropharynx NOS
42040 GP clinical event records B070.00 Malignant neoplasm of roof of nasopharynx
42040 GP clinical event records B071000 Malignant neoplasm of adenoid
42040 GP clinical event records B071100 Malignant neoplasm of pharyngeal tonsil
42040 GP clinical event records B071.00 Malignant neoplasm of posterior wall of nasopharynx
42040 GP clinical event records B071z00 Malignant neoplasm of posterior wall of nasopharynx NOS
42040 GP clinical event records B072000 Malignant neoplasm of pharyngeal recess
42040 GP clinical event records B072.00 Malignant neoplasm of lateral wall of nasopharynx
42040 GP clinical event records B072z00 Malignant neoplasm of lateral wall of nasopharynx NOS
42040 GP clinical event records B073100 Malignant neoplasm of nasopharyngeal soft palate surface
42040 GP clinical event records B073200 Malignant neoplasm posterior margin nasal septum and choanae
42040 GP clinical event records B073.00 Malignant neoplasm of anterior wall of nasopharynx
42040 GP clinical event records B073z00 Malignant neoplasm of anterior wall of nasopharynx NOS
42040 GP clinical event records B074.00 Malignant neoplasm, overlapping lesion of nasopharynx
42040 GP clinical event records B07..00 Malignant neoplasm of nasopharynx
42040 GP clinical event records B07y.00 Malignant neoplasm of other specified site of nasopharynx
42040 GP clinical event records B07z.00 Malignant neoplasm of nasopharynx NOS
42040 GP clinical event records B080.00 Malignant neoplasm of postcricoid region
42040 GP clinical event records B081.00 Malignant neoplasm of pyriform sinus
42040 GP clinical event records B082.00 Malignant neoplasm aryepiglottic fold, hypopharyngeal aspect
42040 GP clinical event records B083.00 Malignant neoplasm of posterior pharynx
42040 GP clinical event records B08..00 Malignant neoplasm of hypopharynx
42040 GP clinical event records B08y.00 Malignant neoplasm of other specified hypopharyngeal site
42040 GP clinical event records B08z.00 Malignant neoplasm of hypopharynx NOS
42040 GP clinical event records B0…00 Malignant neoplasm of lip, oral cavity and pharynx
42040 GP clinical event records B0…11 Carcinoma of lip, oral cavity and pharynx
42040 GP clinical event records B0z0.00 Malignant neoplasm of pharynx unspecified
42040 GP clinical event records B0z1.00 Malignant neoplasm of Waldeyer’s ring
42040 GP clinical event records B0z2.00 Malignant neoplasm of laryngopharynx
42040 GP clinical event records B0z..00 Malig neop other/ill-defined sites lip, oral cavity, pharynx
42040 GP clinical event records B0zy.00 Malignant neoplasm of other sites lip, oral cavity, pharynx
42040 GP clinical event records B0zz.00 Malignant neoplasm of lip, oral cavity and pharynx NOS
42040 GP clinical event records BB5y000 [M]Basal cell adenocarcinoma
42040 GP clinical event records Byu0.00 [X]Malignant neoplasm of lip, oral cavity and pharynx
42040 GP clinical event records ZV10019 [V]Personal history of malignant neoplasm of tongue
42040 GP clinical event records ZV10y16 [V]Personal history of malignant neoplasm of tongue
42040 GP clinical event records XaC2J Malignant neoplasm of lip, unspecified
42040 GP clinical event records XE2rk Malignant neoplasm of lip, oral cavity and pharynx
40006 Type of cancer: ICD10 C00 Malignant neoplasm of lip
40006 Type of cancer: ICD10 C01 Malignant neoplasm of base of tongue
40006 Type of cancer: ICD10 C02 Malignant neoplasm of other and unspecified parts of tongue
40006 Type of cancer: ICD10 C03 Malignant neoplasm of gum
40006 Type of cancer: ICD10 C04 Malignant neoplasm of floor of mouth
40006 Type of cancer: ICD10 C05 Malignant neoplasm of palate
40006 Type of cancer: ICD10 C06 Malignant neoplasm of other and unspecified parts of mouth
40006 Type of cancer: ICD10 C07 Malignant neoplasm of parotid gland
40006 Type of cancer: ICD10 C08 Malignant neoplasm of other and unspecified major salivary glands
40006 Type of cancer: ICD10 C09 Malignant neoplasm of tonsil
40006 Type of cancer: ICD10 C10 Malignant neoplasm of oropharynx
40006 Type of cancer: ICD10 C11 Malignant neoplasm of nasopharynx
40006 Type of cancer: ICD10 C12 Malignant neoplasm of piriform sinus
40006 Type of cancer: ICD10 C13 Malignant neoplasm of hypopharynx
40006 Type of cancer: ICD10 C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx