| Name |
Primary Malignancy of Ovarian (pri_ovarian) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
0f67b550-00cf-4b18-aa7a-5afbc33338f1 |
| Definition |
Ovarian cancer is a type of cancer that begins in the ovaries. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
2677 |
| Female (%) |
2677 (100%) |
| Male (%) |
0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
48.68 (44.0,53.37) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by sex
| Female |
4.59 (4.03,5.15) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 |
1.11 (0.45,1.76) |
| Ages 45-49 |
1.41 (0.78,2.04) |
| Ages 50-54 |
1.78 (1.12,2.43) |
| Ages 55-59 |
2.97 (2.2,3.74) |
| Ages 60-64 |
2.85 (2.2,3.5) |
| Ages 65-69 |
3.58 (2.75,4.41) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
16 (12,20) |
27 (23,31) |
42 (38,46) |
| CALIBER |
20 (18,22) |
41 (38,43) |
69 (65,73) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
19(11,31) |
22(15,31) |
43(34,52) |
| Low |
14(7,25) |
28(20,38) |
45(37,55) |
| Medium |
15(8,26) |
33(24,43) |
45(36,55) |
| High |
14(8,24) |
29(21,39) |
37(29,47) |
| Most deprived |
18(11,27) |
23(16,32) |
40(31,50) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
17(13,21) |
29(24,33) |
41(37,46) |
| Scotland |
7(2,18) |
22(14,33) |
40(29,53) |
| Wales |
24(10,48) |
20(10,35) |
53(38,73) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153944, Events=165
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.93 (0.64, 1.33) |
0.683 |
| BMI |
obese |
0.99 (0.66, 1.49) |
0.954 |
| BMI |
underweight |
0 (0, Inf) |
0.994 |
| smoking |
previous |
1.57 (1.13, 2.18) |
0.00649 |
| smoking |
current |
1.16 (0.66, 2.02) |
0.611 |
| hypertension |
yes |
0.69 (0.47, 1.01) |
0.0533 |
Genetic correlation
| Genetic correlation (rg) |
P value |
| 0.77 |
0.293 |
Published study: Phelan (2017)
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20001 |
Cancer code, self-reported |
1039 |
ovarian cancer |
| 41202 |
Diagnoses - main ICD10 |
C56 |
Malignant neoplasm of ovary |
| 41204 |
Diagnoses - secondary ICD10 |
C56 |
Malignant neoplasm of ovary |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C56 |
Malignant neoplasm of ovary |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C56 |
Malignant neoplasm of ovary |
| 42040 |
GP clinical event records |
B440.00 |
Malignant neoplasm of ovary |
| 42040 |
GP clinical event records |
B440.11 |
Cancer of ovary |
| 42040 |
GP clinical event records |
BB5j200 |
[M]Endometrioid carcinoma |
| 42040 |
GP clinical event records |
BB5j500 |
[M]Endometrioid adenofibroma, malignant |
| 42040 |
GP clinical event records |
BBQA100 |
[M]Struma ovarii, malignant |
| 42040 |
GP clinical event records |
D212000 |
Anaemia in ovarian carcinoma |
| 42040 |
GP clinical event records |
ZV10414 |
[V]Personal history of malignant neoplasm of ovary |
| 42040 |
GP clinical event records |
XaBDS |
Anaemia in ovarian carcinoma |
| 40006 |
Type of cancer: ICD10 |
C56 |
Malignant neoplasm of ovary |