| Name |
Primary Malignancy of Pancreatic (pri_pancr) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
d90aca1e-72e8-4f3f-9969-637373cecabd |
| Definition |
A primary or metastatic malignant tumor involving the pancreas. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1898 |
| Female (%) |
873 (46%) |
| Male (%) |
1025 (54%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
1.77 (0.87,2.66) |
| Male |
3.36 (2.02,4.7) |
Incidence stratified by sex
| Female |
1.76 (1.41,2.1) |
| Male |
2.46 (2.02,2.91) |
Incidence stratified by age
| Ages 40-44 |
0.2 (-0.08,0.48) |
| Ages 45-49 |
0.37 (0.05,0.7) |
| Ages 50-54 |
1.39 (0.81,1.97) |
| Ages 55-59 |
1.3 (0.79,1.81) |
| Ages 60-64 |
3.07 (2.4,3.74) |
| Ages 65-69 |
4.17 (3.27,5.06) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
3 (1,5) |
8 (6,10) |
20 (17,23) |
| CALIBER |
3 (2,3) |
9 (8,10) |
22 (20,23) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
3(0,9) |
4(2,10) |
20(14,27) |
| Low |
0(NaN,NaN) |
4(1,8) |
18(13,25) |
| Medium |
1(0,8) |
11(6,19) |
14(9,21) |
| High |
6(2,14) |
9(4,16) |
20(14,28) |
| Most deprived |
4(1,10) |
10(5,17) |
28(20,37) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
3(1,5) |
8(6,11) |
19(16,23) |
| Scotland |
5(1,15) |
6(2,15) |
18(10,28) |
| Wales |
0(NaN,NaN) |
4(0,14) |
29(18,45) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153944, Events=165
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.93 (0.64, 1.33) |
0.683 |
| BMI |
obese |
0.99 (0.66, 1.49) |
0.954 |
| BMI |
underweight |
0 (0, Inf) |
0.994 |
| smoking |
previous |
1.57 (1.13, 2.18) |
0.00649 |
| smoking |
current |
1.16 (0.66, 2.02) |
0.611 |
| hypertension |
yes |
0.69 (0.47, 1.01) |
0.0533 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20001 |
Cancer code, self-reported |
1026 |
pancreas cancer |
| 41202 |
Diagnoses - main ICD10 |
C25 |
Malignant neoplasm of pancreas |
| 41204 |
Diagnoses - secondary ICD10 |
C25 |
Malignant neoplasm of pancreas |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C25 |
Malignant neoplasm of pancreas |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C25 |
Malignant neoplasm of pancreas |
| 42040 |
GP clinical event records |
B170.00 |
Malignant neoplasm of head of pancreas |
| 42040 |
GP clinical event records |
B171.00 |
Malignant neoplasm of body of pancreas |
| 42040 |
GP clinical event records |
B172.00 |
Malignant neoplasm of tail of pancreas |
| 42040 |
GP clinical event records |
B173.00 |
Malignant neoplasm of pancreatic duct |
| 42040 |
GP clinical event records |
B174.00 |
Malignant neoplasm of Islets of Langerhans |
| 42040 |
GP clinical event records |
B175.00 |
Malignant neoplasm, overlapping lesion of pancreas |
| 42040 |
GP clinical event records |
B17..00 |
Malignant neoplasm of pancreas |
| 42040 |
GP clinical event records |
B17y000 |
Malignant neoplasm of ectopic pancreatic tissue |
| 42040 |
GP clinical event records |
B17y.00 |
Malignant neoplasm of other specified sites of pancreas |
| 42040 |
GP clinical event records |
B17yz00 |
Malignant neoplasm of specified site of pancreas NOS |
| 42040 |
GP clinical event records |
B17z.00 |
Malignant neoplasm of pancreas NOS |
| 42040 |
GP clinical event records |
BB5B100 |
[M]Islet cell carcinoma |
| 42040 |
GP clinical event records |
BB5B300 |
[M]Insulinoma, malignant |
| 42040 |
GP clinical event records |
BB5B500 |
[M]Glucagonoma, malignant |
| 42040 |
GP clinical event records |
BB5B600 |
[M]Mixed islet cell and exocrine adenocarcinoma |
| 42040 |
GP clinical event records |
BB5C100 |
[M]Gastrinoma, malignant |
| 40006 |
Type of cancer: ICD10 |
C25 |
Malignant neoplasm of pancreas |