Metadata
| Name | Primary Malignancy of Prostate (pri_prost) |
| Category | Cancers |
| Sex | |
| Adult | Yes |
| UUID | fab450a8-eb00-4d7e-9a06-8d8fd5cea758 |
| Definition | A male reproductive organ cancer that is located_in the prostate. |
Ontologies
| Disease Ontology (DOID) | DOID_10283 |
| GWAS Catalogue | EFO_0001663 |
| MeSH | D011471 |
| SNOMED-CT | 254900004 |
| FinnGen | C3_PROSTATE |
Key Summary Statistics
Cases from any source
| Total | 15157 |
| Female (%) | 0 (0%) |
| Male (%) | 15157 (100%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 0.0 (0.0,0.0) |
| Male | 165.75 (156.39,175.11) |
Incidence stratified by sex
| Female | 0.0 (0.0,0.0) |
| Male | 41.02 (39.18,42.87) |
Incidence stratified by age
| Ages 40-44 | 0.5 (0.06,0.94) |
| Ages 45-49 | 2.97 (2.05,3.89) |
| Ages 50-54 | 7.75 (6.37,9.12) |
| Ages 55-59 | 14.52 (12.81,16.23) |
| Ages 60-64 | 27.86 (25.82,29.91) |
| Ages 65-69 | 38.24 (35.48,41.0) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 9 (6,13) | 90 (83,98) | 317 (305,329) |
| CALIBER | 12 (11,14) | 103 (99,107) | 432 (422,441) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 9(3,20) | 110(91,131) | 310(285,336) |
| Low | 5(1,14) | 81(65,100) | 327(301,354) |
| Medium | 12(5,23) | 87(70,106) | 342(315,371) |
| High | 10(4,20) | 99(81,118) | 299(273,328) |
| Most deprived | 9(4,17) | 76(62,93) | 302(275,331) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 8(5,12) | 92(83,101) | 315(302,329) |
| Scotland | 7(1,20) | 77(59,99) | 315(280,352) |
| Wales | 22(8,48) | 99(73,133) | 340(296,387) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153944, Events=165
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.93 (0.64, 1.33) | 0.683 |
| BMI | obese | 0.99 (0.66, 1.49) | 0.954 |
| BMI | underweight | 0 (0, Inf) | 0.994 |
| smoking | previous | 1.57 (1.13, 2.18) | 0.00649 |
| smoking | current | 1.16 (0.66, 2.02) | 0.611 |
| hypertension | yes | 0.69 (0.47, 1.01) | 0.0533 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20001 | Cancer code, self-reported | 1044 | prostate cancer |
| 41202 | Diagnoses - main ICD10 | C61 | Malignant neoplasm of prostate |
| 41204 | Diagnoses - secondary ICD10 | C61 | Malignant neoplasm of prostate |
| 40001 | Underlying (primary) cause of death: ICD10 | C61 | Malignant neoplasm of prostate |
| 40002 | Contributory (secondary) causes of death: ICD10 | C61 | Malignant neoplasm of prostate |
| 42040 | GP clinical event records | 1427000.0 | H/O: prostate cancer |
| 42040 | GP clinical event records | 4M00.00 | Gleason prostate grade 2-4 (low) |
| 42040 | GP clinical event records | 4M01.00 | Gleason prostate grade 5-7 (medium) |
| 42040 | GP clinical event records | 4M02.00 | Gleason prostate grade 8-10 (high) |
| 42040 | GP clinical event records | 4M0..00 | Gleason grading of prostate cancer |
| 42040 | GP clinical event records | 7B20000 | Radical cystoprostatourethrectomy |
| 42040 | GP clinical event records | 7B20200 | Radical cystoprostatectomy |
| 42040 | GP clinical event records | 7B36000 | Radical prostatectomy - unspecified excision of pelvic nodes |
| 42040 | GP clinical event records | 7B36500 | Radical prostatectomy without pelvic node excision |
| 42040 | GP clinical event records | 7B36600 | Radical prostatectomy with pelvic node sampling |
| 42040 | GP clinical event records | 7B36700 | Radical prostatectomy with pelvic lymphadenectomy |
| 42040 | GP clinical event records | B46..00 | Malignant neoplasm of prostate |
| 42040 | GP clinical event records | ZV10415 | [V]Personal history of malignant neoplasm of prostate |
| 42040 | GP clinical event records | XaImc | Gleason prostate grade 5-7 (medium) |
| 42040 | GP clinical event records | XaImd | Gleason prostate grade 8-10 (high) |
| 42040 | GP clinical event records | XaImb | Gleason prostate grade 2-4 (low) |
| 42040 | GP clinical event records | XaIma | Gleason grading of prostate cancer |
| 42040 | GP clinical event records | XaXGk | H/O: prostate cancer |
| 40006 | Type of cancer: ICD10 | C61 | Malignant neoplasm of prostate |