Metadata

Name Primary Malignancy of Other Skin and subcutaneous tissue (pri_skin)
Category Cancers
Sex
Adult Yes
UUID c75e6deb-d88d-469b-9f55-873057f087a0
Definition A benign or malignant tumor involving the skin. Representative examples of benign skin neoplasms include the benign melanocytic skin nevus, acanthoma, sebaceous adenoma, sweat gland adenoma, lipoma, hemangioma, fibroma, and benign fibrous histiocytoma. Representative examples of malignant skin neoplasms include basal cell carcinoma, squamous cell carcinoma, melanoma, and Kaposi sarcoma.

Ontologies

Disease Ontology (DOID) DOID_4159
GWAS Catalogue EFO_0009260
MeSH D012878
SNOMED-CT 126488004
FinnGen C3_SKIN

Key Summary Statistics

Cases from any source

Total 36059
Female (%) 17357 (48%)
Male (%) 18702 (52%)

Year first recorded

pri_skin year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced pri_skin cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of pri_skin

Baseline prevalence stratified by sex

Female 257.68 (247.02,268.34)
Male 292.73 (280.36,305.09)

Incidence stratified by sex

Female 39.78 (38.11,41.45)
Male 50.79 (48.72,52.87)

Incidence stratified by age

Ages 40-44 12.3 (10.11,14.49)
Ages 45-49 18.29 (15.99,20.59)
Ages 50-54 25.28 (22.77,27.79)
Ages 55-59 39.07 (36.22,41.91)
Ages 60-64 60.54 (57.48,63.61)
Ages 65-69 82.13 (77.99,86.27)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB pri_skin prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 163 (151,175) 343 (329,358) 757 (740,776)
CALIBER 103 (100,105) 249 (244,254) 584 (576,591)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 185(155,219) 393(359,428) 881(839,924)
Low 190(159,225) 387(354,423) 794(755,835)
Medium 153(126,183) 364(332,398) 791(751,833)
High 175(149,205) 311(281,343) 689(650,730)
Most deprived 125(105,149) 267(240,296) 594(556,633)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 155(142,169) 326(311,342) 727(707,747)
Scotland 181(146,222) 368(329,411) 810(757,866)
Wales 218(168,277) 471(414,534) 1001(927,1078)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153944, Events=165

Factor Level Hazard Ratio P value
BMI overweight 0.93 (0.64, 1.33) 0.683
BMI obese 0.99 (0.66, 1.49) 0.954
BMI underweight 0 (0, Inf) 0.994
smoking previous 1.57 (1.13, 2.18) 0.00649
smoking current 1.16 (0.66, 2.02) 0.611
hypertension yes 0.69 (0.47, 1.01) 0.0533

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20001 Cancer code, self-reported 1003 skin cancer
20001 Cancer code, self-reported 1060 non-melanoma skin cancer
41202 Diagnoses - main ICD10 C44 Other malignant neoplasms of skin
41204 Diagnoses - secondary ICD10 C44 Other malignant neoplasms of skin
40001 Underlying (primary) cause of death: ICD10 C44 Other malignant neoplasms of skin
40002 Contributory (secondary) causes of death: ICD10 C44 Other malignant neoplasms of skin
42040 GP clinical event records 7G05600 Excision biopsy of rodent ulcer
42040 GP clinical event records 7G05D00 Excision biopsy of basal cell carcinoma
42040 GP clinical event records B330.00 Malignant neoplasm of skin of lip
42040 GP clinical event records B331000 Malignant neoplasm of canthus
42040 GP clinical event records B331100 Malignant neoplasm of upper eyelid
42040 GP clinical event records B331200 Malignant neoplasm of lower eyelid
42040 GP clinical event records B331.00 Malignant neoplasm of eyelid including canthus
42040 GP clinical event records B332000 Malignant neoplasm of skin of auricle (ear)
42040 GP clinical event records B332100 Malignant neoplasm of skin of external auditory meatus
42040 GP clinical event records B332200 Malignant neoplasm of pinna NEC
42040 GP clinical event records B332.00 Malignant neoplasm skin of ear and external auricular canal
42040 GP clinical event records B332z00 Malig neop skin of ear and external auricular canal NOS
42040 GP clinical event records B333000 Malignant neoplasm of skin of cheek, external
42040 GP clinical event records B333100 Malignant neoplasm of skin of chin
42040 GP clinical event records B333200 Malignant neoplasm of skin of eyebrow
42040 GP clinical event records B333300 Malignant neoplasm of skin of forehead
42040 GP clinical event records B333400 Malignant neoplasm of skin of nose (external)
42040 GP clinical event records B333500 Malignant neoplasm of skin of temple
42040 GP clinical event records B333.00 Malignant neoplasm skin of other and unspecified parts face
42040 GP clinical event records B333z00 Malignant neoplasm skin other and unspec part of face NOS
42040 GP clinical event records B334000 Malignant neoplasm of scalp
42040 GP clinical event records B334100 Malignant neoplasm of skin of neck
42040 GP clinical event records B334.00 Malignant neoplasm of scalp and skin of neck
42040 GP clinical event records B334z00 Malignant neoplasm of scalp or skin of neck NOS
42040 GP clinical event records B335000 Malignant neoplasm of skin of axillary fold
42040 GP clinical event records B335100 Malignant neoplasm of skin of chest, excluding breast
42040 GP clinical event records B335200 Malignant neoplasm of skin of breast
42040 GP clinical event records B335300 Malignant neoplasm of skin of abdominal wall
42040 GP clinical event records B335400 Malignant neoplasm of skin of umbilicus
42040 GP clinical event records B335500 Malignant neoplasm of skin of groin
42040 GP clinical event records B335600 Malignant neoplasm of skin of perineum
42040 GP clinical event records B335700 Malignant neoplasm of skin of back
42040 GP clinical event records B335800 Malignant neoplasm of skin of buttock
42040 GP clinical event records B335900 Malignant neoplasm of perianal skin
42040 GP clinical event records B335A00 Malignant neoplasm of skin of scapular region
42040 GP clinical event records B335.00 Malignant neoplasm of skin of trunk, excluding scrotum
42040 GP clinical event records B335z00 Malignant neoplasm of skin of trunk, excluding scrotum, NOS
42040 GP clinical event records B336000 Malignant neoplasm of skin of shoulder
42040 GP clinical event records B336100 Malignant neoplasm of skin of upper arm
42040 GP clinical event records B336200 Malignant neoplasm of skin of fore-arm
42040 GP clinical event records B336300 Malignant neoplasm of skin of hand
42040 GP clinical event records B336400 Malignant neoplasm of skin of finger
42040 GP clinical event records B336500 Malignant neoplasm of skin of thumb
42040 GP clinical event records B336.00 Malignant neoplasm of skin of upper limb and shoulder
42040 GP clinical event records B336z00 Malignant neoplasm of skin of upper limb or shoulder NOS
42040 GP clinical event records B337000 Malignant neoplasm of skin of hip
42040 GP clinical event records B337100 Malignant neoplasm of skin of thigh
42040 GP clinical event records B337200 Malignant neoplasm of skin of knee
42040 GP clinical event records B337300 Malignant neoplasm of skin of popliteal fossa area
42040 GP clinical event records B337400 Malignant neoplasm of skin of lower leg
42040 GP clinical event records B337500 Malignant neoplasm of skin of ankle
42040 GP clinical event records B337600 Malignant neoplasm of skin of heel
42040 GP clinical event records B337700 Malignant neoplasm of skin of foot
42040 GP clinical event records B337800 Malignant neoplasm of skin of toe
42040 GP clinical event records B337900 Malignant neoplasm of skin of great toe
42040 GP clinical event records B337.00 Malignant neoplasm of skin of lower limb and hip
42040 GP clinical event records B337z00 Malignant neoplasm of skin of lower limb or hip NOS
42040 GP clinical event records B338.00 Squamous cell carcinoma of skin
42040 GP clinical event records B339.00 Dermatofibrosarcoma protuberans
42040 GP clinical event records B33..00 Other malignant neoplasm of skin
42040 GP clinical event records B33..11 Basal cell carcinoma
42040 GP clinical event records B33..13 Rodent ulcer
42040 GP clinical event records B33..14 Malignant neoplasm of sebaceous gland
42040 GP clinical event records B33..15 Malignant neoplasm of sweat gland
42040 GP clinical event records B33..16 Epithelioma basal cell
42040 GP clinical event records B33X.00 Malignant neoplasm overlapping lesion of skin
42040 GP clinical event records B33y.00 Malignant neoplasm of other specified skin sites
42040 GP clinical event records B33z.00 Malignant neoplasm of skin NOS
42040 GP clinical event records B33z.11 Squamous cell carcinoma of skin NOS
42040 GP clinical event records BB2A.13 [M]Squamous cell carcinoma of skin NOS
42040 GP clinical event records BB30.00 [M]Basal cell tumour
42040 GP clinical event records BB31.00 [M]Basal cell carcinoma NOS
42040 GP clinical event records BB32.00 [M]Multicentric basal cell carcinoma
42040 GP clinical event records BB33.00 [M]Basal cell carcinoma, morphoea type
42040 GP clinical event records BB34.00 [M]Basal cell carcinoma, fibroepithelial type
42040 GP clinical event records BB35.00 [M]Basosquamous carcinoma
42040 GP clinical event records BB36.00 [M]Metatypical carcinoma
42040 GP clinical event records BB3..00 [M]Basal cell neoplasms
42040 GP clinical event records BB3C.00 [M]Superficial basal cell carcinoma
42040 GP clinical event records BB3D.00 [M]Basal cell carcinoma, nodular
42040 GP clinical event records BB3E.00 [M]Basal cell carcinoma, micronodular
42040 GP clinical event records BB3F.00 [M]Basal cell carcinoma, infiltrative
42040 GP clinical event records BB3G.00 [M]Pigmented basal cell carcinoma
42040 GP clinical event records BB3z.00 [M]Basal cell neoplasm NOS
42040 GP clinical event records BB60100 [M]Skin appendage carcinoma
42040 GP clinical event records BB61200 [M]Sweat gland adenocarcinoma
42040 GP clinical event records BB62100 [M]Apocrine adenocarcinoma
42040 GP clinical event records BB69100 [M]Sebaceous adenocarcinoma
42040 GP clinical event records Byu4200 [X]Oth malignant neoplasm/skin of oth+unspecfd parts of face
42040 GP clinical event records Byu4300 [X]Malignant neoplasm of skin, unspecified
42040 GP clinical event records Byu5A00 [X]Malignant neoplasm overlapping lesion of skin
42040 GP clinical event records ZV10y14 [V]Personal history of malignant neoplasm of skin
42040 GP clinical event records XaEGW Malignant neoplasm of lower eyelid
42040 GP clinical event records XE1vh Other malignant neoplasm of skin
42040 GP clinical event records XaD2Q Malignant neoplasm of skin of scapular region
42040 GP clinical event records Xa0D9 Dermatofibrosarcoma protuberans
42040 GP clinical event records XaEGV Malignant neoplasm of upper eyelid
42040 GP clinical event records 7G056 Excision biopsy of basal cell carcinoma
42040 GP clinical event records X78RR Squamous cell carcinoma of skin
42040 GP clinical event records XaD2P Malignant neoplasm of pinna NEC
42040 GP clinical event records XaCKx Malignant neoplasm of canthus
40006 Type of cancer: ICD10 C44 Other malignant neoplasms of skin