Primary Malignancy of Stomach

Metadata

Name	Primary Malignancy of Stomach (pri_stomach)
Category	Cancers
Sex
Adult	Yes
UUID	0aad0376-027f-47fe-90f6-9771d09967e4
Definition	A benign or malignant neoplasm involving the stomach.

Ontologies

Disease Ontology (DOID)	DOID_10534
GWAS Catalogue	EFO_1001252
MeSH	D013274
SNOMED-CT	363349007
FinnGen	C3_STOMACH

Key Summary Statistics

Cases from any source

Total	1491
Female (%)	476 (32%)
Male (%)	1015 (68%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	4.48 (3.06,5.9)
Male	8.12 (6.03,10.21)

Incidence stratified by sex

Female	0.88 (0.63,1.12)
Male	2.84 (2.36,3.32)

Incidence stratified by age

Ages 40-44	0.2 (-0.08,0.48)
Ages 45-49	0.82 (0.33,1.3)
Ages 50-54	0.95 (0.47,1.43)
Ages 55-59	1.61 (1.04,2.18)
Ages 60-64	1.88 (1.35,2.41)
Ages 65-69	3.87 (3.01,4.73)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	3 (1,5)	11 (8,14)	21 (18,24)
CALIBER	3 (2,3)	9 (8,10)	21 (20,22)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	6(2,14)	6(3,13)	19(13,26)
Low	3(0,9)	9(5,17)	26(19,34)
Medium	1(0,8)	15(9,24)	14(9,20)
High	0(NaN,NaN)	6(3,12)	23(17,32)
Most deprived	5(2,11)	16(10,25)	25(18,34)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	3(1,5)	9(7,13)	21(18,24)
Scotland	4(0,15)	12(6,23)	24(15,36)
Wales	3(0,17)	21(10,38)	21(11,35)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153944, Events=165

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.93 (0.64, 1.33)	0.683
BMI	obese	0.99 (0.66, 1.49)	0.954
BMI	underweight	0 (0, Inf)	0.994
smoking	previous	1.57 (1.13, 2.18)	0.00649
smoking	current	1.16 (0.66, 2.02)	0.611
hypertension	yes	0.69 (0.47, 1.01)	0.0533

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1018	stomach cancer
41202	Diagnoses - main ICD10	C16	Malignant neoplasm of stomach
41204	Diagnoses - secondary ICD10	C16	Malignant neoplasm of stomach
40001	Underlying (primary) cause of death: ICD10	C16	Malignant neoplasm of stomach
40002	Contributory (secondary) causes of death: ICD10	C16	Malignant neoplasm of stomach
42040	GP clinical event records	B110000	Malignant neoplasm of cardiac orifice of stomach
42040	GP clinical event records	B110100	Malignant neoplasm of cardio-oesophageal junction of stomach
42040	GP clinical event records	B110111	Malignant neoplasm of gastro-oesophageal junction
42040	GP clinical event records	B110.00	Malignant neoplasm of cardia of stomach
42040	GP clinical event records	B110z00	Malignant neoplasm of cardia of stomach NOS
42040	GP clinical event records	B111000	Malignant neoplasm of prepylorus of stomach
42040	GP clinical event records	B111100	Malignant neoplasm of pyloric canal of stomach
42040	GP clinical event records	B111.00	Malignant neoplasm of pylorus of stomach
42040	GP clinical event records	B111z00	Malignant neoplasm of pylorus of stomach NOS
42040	GP clinical event records	B112.00	Malignant neoplasm of pyloric antrum of stomach
42040	GP clinical event records	B113.00	Malignant neoplasm of fundus of stomach
42040	GP clinical event records	B114.00	Malignant neoplasm of body of stomach
42040	GP clinical event records	B115.00	Malignant neoplasm of lesser curve of stomach unspecified
42040	GP clinical event records	B116.00	Malignant neoplasm of greater curve of stomach unspecified
42040	GP clinical event records	B117.00	Malignant neoplasm, overlapping lesion of stomach
42040	GP clinical event records	B118.00	Siewert type II adenocarcinoma
42040	GP clinical event records	B119.00	Siewert type III adenocarcinoma
42040	GP clinical event records	B11..00	Malignant neoplasm of stomach
42040	GP clinical event records	B11y000	Malignant neoplasm of anterior wall of stomach NEC
42040	GP clinical event records	B11y100	Malignant neoplasm of posterior wall of stomach NEC
42040	GP clinical event records	B11y.00	Malignant neoplasm of other specified site of stomach
42040	GP clinical event records	B11yz00	Malignant neoplasm of other specified site of stomach NOS
42040	GP clinical event records	B11z.00	Malignant neoplasm of stomach NOS
42040	GP clinical event records	ZV10018	[V]Personal history of malignant neoplasm of stomach
42040	GP clinical event records	XaOrB	Siewert type III adenocarcinoma
42040	GP clinical event records	XaOqX	Siewert type II adenocarcinoma
40006	Type of cancer: ICD10	C16	Malignant neoplasm of stomach