Metadata
| Name | Primary or Idiopathic Thrombocytopaenia (pri_thrombocytopaenia) |
| Category | Haematological or immunological |
| Sex | |
| Adult | Yes |
| UUID | 84af6f13-2bca-4715-9547-1b208dc961af |
| Definition | A condition characterized by abnormally low levels of platelets, also known as thrombocytes, in the blood. |
Ontologies
| Disease Ontology (DOID) | DOID_8925 |
| GWAS Catalogue | MONDO_0004680 |
| SNOMED-CT | 267534000 |
| FinnGen | D3_OTHPRIMTHROMBOCYTOPENIA |
Key Summary Statistics
Cases from any source
| Total | 1604 |
| Female (%) | 820 (51%) |
| Male (%) | 784 (49%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 27.94 (24.39,31.49) |
| Male | 23.94 (20.36,27.52) |
Incidence stratified by sex
| Female | 1.87 (1.51,2.22) |
| Male | 3.14 (2.64,3.65) |
Incidence stratified by age
| Ages 40-44 | 1.01 (0.38,1.63) |
| Ages 45-49 | 1.41 (0.78,2.05) |
| Ages 50-54 | 1.78 (1.12,2.44) |
| Ages 55-59 | 2.5 (1.79,3.21) |
| Ages 60-64 | 2.96 (2.3,3.63) |
| Ages 65-69 | 3.68 (2.84,4.52) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 26 (21,31) | 38 (33,43) | 49 (45,54) |
| CALIBER | 13 (12,14) | 15 (14,16) | 20 (18,21) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 13(6,24) | 26(18,36) | 50(40,61) |
| Low | 32(21,48) | 35(26,48) | 51(42,63) |
| Medium | 27(16,41) | 34(24,45) | 44(35,55) |
| High | 21(12,32) | 45(34,58) | 52(41,64) |
| Most deprived | 35(25,49) | 49(38,63) | 49(39,61) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 27(22,33) | 39(34,45) | 48(43,54) |
| Scotland | 25(13,44) | 40(28,55) | 52(39,68) |
| Wales | 18(7,39) | 22(11,39) | 54(38,74) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153321, Events=259
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.47 (1.07, 2.01) | 0.0165 |
| BMI | obese | 2.46 (1.81, 3.35) | 1.19e-08 |
| BMI | underweight | 0 (0, Inf) | 0.998 |
| smoking | previous | 1.06 (0.81, 1.39) | 0.676 |
| smoking | current | 0.75 (0.46, 1.22) | 0.25 |
| hypertension | yes | 0.83 (0.58, 1.19) | 0.31 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 41202 | Diagnoses - main ICD10 | D69.3 | Idiopathic thrombocytopenic purpura |
| 41202 | Diagnoses - main ICD10 | D69.4 | Other primary thrombocytopenia |
| 41204 | Diagnoses - secondary ICD10 | D69.3 | Idiopathic thrombocytopenic purpura |
| 41204 | Diagnoses - secondary ICD10 | D69.4 | Other primary thrombocytopenia |
| 40001 | Underlying (primary) cause of death: ICD10 | D69.3 | Idiopathic thrombocytopenic purpura |
| 40001 | Underlying (primary) cause of death: ICD10 | D69.4 | Other primary thrombocytopenia |
| 40002 | Contributory (secondary) causes of death: ICD10 | D69.3 | Idiopathic thrombocytopenic purpura |
| 40002 | Contributory (secondary) causes of death: ICD10 | D69.4 | Other primary thrombocytopenia |
| 42040 | GP clinical event records | 42P2.11 | Auto-immune thrombocytopenia |
| 42040 | GP clinical event records | D313000 | Idiopathic thrombocytopenic purpura |
| 42040 | GP clinical event records | D313011 | Idiopathic purpura |
| 42040 | GP clinical event records | D313012 | ITP - idiopathic thrombocytopenic purpura |
| 42040 | GP clinical event records | D313100 | Congenital thrombocytopenic purpura |
| 42040 | GP clinical event records | D313111 | Hereditary thrombocytopenia NEC |
| 42040 | GP clinical event records | D313300 | [X]Essential thrombocytopenia NOS |
| 42040 | GP clinical event records | D313.00 | Primary thrombocytopenia |
| 42040 | GP clinical event records | D313.11 | Evan’s syndrome |
| 42040 | GP clinical event records | D313.12 | Idiopathic thrombocytopenic purpura |
| 42040 | GP clinical event records | D313.13 | Idiopathic purpura |
| 42040 | GP clinical event records | D313.14 | Megakaryocytic hypoplasia |
| 42040 | GP clinical event records | D313.15 | Thrombocytopenic purpura |
| 42040 | GP clinical event records | D313y00 | Other specified primary thrombocytopenia |
| 42040 | GP clinical event records | D313z00 | Primary thrombocytopenia NOS |
| 42040 | GP clinical event records | D313z11 | Essential thrombocytopenia NOS |
| 42040 | GP clinical event records | Dyu3200 | [X]Other primary thrombocytopenia |
| 42040 | GP clinical event records | XE148 | Primary thrombocytopenia NOS |
| 42040 | GP clinical event records | XE145 | Primary thrombocytopenia |
| 42040 | GP clinical event records | XE146 | Idiopathic thrombocytopenic purpura |
| 42040 | GP clinical event records | XE24o | Thrombocytopenia |
| 42040 | GP clinical event records | XE147 | Congenital thrombocytopenic purpura |