Metadata

Name Primary Malignancy of Thyroid (pri_thyroid)
Category Cancers
Sex
Adult Yes
UUID b540d177-a561-4631-9f2b-f121b955121e
Definition A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes, follicular, papillary, medullary, poorly differentiated, and anaplastic.

Ontologies

Disease Ontology (DOID) DOID_1781
GWAS Catalogue EFO_0002892
MeSH D013964
SNOMED-CT 363478007
FinnGen C3_THYROID_GLAND

Key Summary Statistics

Cases from any source

Total 1083
Female (%) 818 (76%)
Male (%) 265 (24%)

Year first recorded

pri_thyroid year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced pri_thyroid cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of pri_thyroid

Baseline prevalence stratified by sex

Female 17.8 (14.96,20.64)
Male 4.34 (2.81,5.87)

Incidence stratified by sex

Female 1.27 (0.97,1.56)
Male 0.44 (0.25,0.63)

Incidence stratified by age

Ages 40-44 0.5 (0.06,0.94)
Ages 45-49 1.26 (0.66,1.86)
Ages 50-54 0.95 (0.47,1.43)
Ages 55-59 1.09 (0.63,1.56)
Ages 60-64 0.92 (0.55,1.29)
Ages 65-69 0.55 (0.23,0.88)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB pri_thyroid prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 11 (8,14) 15 (12,18) 14 (12,17)
CALIBER 8 (8,9) 10 (9,11) 11 (10,12)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 12(5,22) 17(11,25) 11(7,17)
Low 13(6,24) 14(9,22) 16(11,22)
Medium 9(3,18) 14(8,21) 14(9,20)
High 9(4,18) 15(9,23) 16(11,23)
Most deprived 10(5,18) 15(10,23) 15(10,23)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 11(8,15) 17(14,21) 14(11,17)
Scotland 9(3,22) 12(6,21) 16(9,25)
Wales 10(2,29) 4(0,14) 18(10,32)

Definition

UK Biobank field id Description Code Value
20001 Cancer code, self-reported 1065 thyroid cancer
41202 Diagnoses - main ICD10 C73 Malignant neoplasm of thyroid gland
41204 Diagnoses - secondary ICD10 C73 Malignant neoplasm of thyroid gland
40001 Underlying (primary) cause of death: ICD10 C73 Malignant neoplasm of thyroid gland
40002 Contributory (secondary) causes of death: ICD10 C73 Malignant neoplasm of thyroid gland
42040 GP clinical event records B53..00 Malignant neoplasm of thyroid gland
42040 GP clinical event records ZV10y15 [V]Personal history of malignant neoplasm of thyroid
40006 Type of cancer: ICD10 C73 Malignant neoplasm of thyroid gland