Metadata
| Name | Primary Malignancy of Uterine (pri_uterine) |
| Category | Cancers |
| Sex | |
| Adult | Yes |
| UUID | 2f9ed465-d7e9-4b36-9d52-edc64e32ccc2 |
| Definition | Tumors or cancer of the UTERUS. |
Ontologies
| Disease Ontology (DOID) | DOID_4363 |
| MeSH | D014594 |
| SNOMED-CT | 10708511000119108 |
| FinnGen | C3_UTERUS_NAS |
Key Summary Statistics
Cases from any source
| Total | 3349 |
| Female (%) | 3349 (100%) |
| Male (%) | 0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 56.7 (51.65,61.75) |
| Male | 0.0 (0.0,0.0) |
Incidence stratified by sex
| Female | 5.55 (4.94,6.17) |
| Male | 0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 | 0.7 (0.18,1.23) |
| Ages 45-49 | 1.48 (0.83,2.14) |
| Ages 50-54 | 2.54 (1.75,3.32) |
| Ages 55-59 | 3.44 (2.61,4.27) |
| Ages 60-64 | 3.86 (3.1,4.61) |
| Ages 65-69 | 4.09 (3.2,4.98) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 9 (6,12) | 25 (21,29) | 52 (48,57) |
| CALIBER | 12 (10,13) | 42 (40,45) | 100 (96,105) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 6(2,15) | 22(15,31) | 50(41,61) |
| Low | 1(0,7) | 31(23,41) | 53(44,64) |
| Medium | 8(3,17) | 24(17,34) | 54(45,65) |
| High | 17(10,27) | 26(19,36) | 50(41,61) |
| Most deprived | 10(5,18) | 21(14,30) | 53(42,65) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 8(5,11) | 24(20,28) | 51(46,56) |
| Scotland | 16(7,30) | 31(21,44) | 54(41,69) |
| Wales | 12(3,31) | 27(15,43) | 67(49,88) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153944, Events=165
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.93 (0.64, 1.33) | 0.683 |
| BMI | obese | 0.99 (0.66, 1.49) | 0.954 |
| BMI | underweight | 0 (0, Inf) | 0.994 |
| smoking | previous | 1.57 (1.13, 2.18) | 0.00649 |
| smoking | current | 1.16 (0.66, 2.02) | 0.611 |
| hypertension | yes | 0.69 (0.47, 1.01) | 0.0533 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20001 | Cancer code, self-reported | 1040 | uterine/endometrial cancer |
| 41202 | Diagnoses - main ICD10 | C54 | Malignant neoplasm of corpus uteri |
| 41202 | Diagnoses - main ICD10 | C55 | Malignant neoplasm of uterus, part unspecified |
| 41204 | Diagnoses - secondary ICD10 | C54 | Malignant neoplasm of corpus uteri |
| 41204 | Diagnoses - secondary ICD10 | C55 | Malignant neoplasm of uterus, part unspecified |
| 40001 | Underlying (primary) cause of death: ICD10 | C54 | Malignant neoplasm of corpus uteri |
| 40001 | Underlying (primary) cause of death: ICD10 | C55 | Malignant neoplasm of uterus, part unspecified |
| 40002 | Contributory (secondary) causes of death: ICD10 | C54 | Malignant neoplasm of corpus uteri |
| 40002 | Contributory (secondary) causes of death: ICD10 | C55 | Malignant neoplasm of uterus, part unspecified |
| 42040 | GP clinical event records | B40..00 | Malignant neoplasm of uterus, part unspecified |
| 42040 | GP clinical event records | B430000 | Malignant neoplasm of cornu of corpus uteri |
| 42040 | GP clinical event records | B430100 | Malignant neoplasm of fundus of corpus uteri |
| 42040 | GP clinical event records | B430200 | Malignant neoplasm of endometrium of corpus uteri |
| 42040 | GP clinical event records | B430211 | Malignant neoplasm of endometrium |
| 42040 | GP clinical event records | B430300 | Malignant neoplasm of myometrium of corpus uteri |
| 42040 | GP clinical event records | B430.00 | Malignant neoplasm of corpus uteri, excluding isthmus |
| 42040 | GP clinical event records | B430z00 | Malignant neoplasm of corpus uteri NOS |
| 42040 | GP clinical event records | B431000 | Malignant neoplasm of lower uterine segment |
| 42040 | GP clinical event records | B431.00 | Malignant neoplasm of isthmus of uterine body |
| 42040 | GP clinical event records | B431z00 | Malignant neoplasm of isthmus of uterine body NOS |
| 42040 | GP clinical event records | B432.00 | Malignant neoplasm of overlapping lesion of corpus uteri |
| 42040 | GP clinical event records | B43..00 | Malignant neoplasm of body of uterus |
| 42040 | GP clinical event records | B43y.00 | Malignant neoplasm of other site of uterine body |
| 42040 | GP clinical event records | B43z.00 | Malignant neoplasm of body of uterus NOS |
| 42040 | GP clinical event records | ZV10417 | [V]Personal history of malignant neoplasm of uterine body |
| 40006 | Type of cancer: ICD10 | C54 | Malignant neoplasm of corpus uteri |
| 40006 | Type of cancer: ICD10 | C55 | Malignant neoplasm of uterus, part unspecified |