| Name |
Psoriatic arthropathy (PSA) |
| Category |
Musculoskeletal |
| Sex |
|
| Adult |
Yes |
| UUID |
a3b717a5-bdbc-4ed5-9b10-f80b10fff1e6 |
| Definition |
Joint inflammation associated with psoriasis. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
2256 |
| Female (%) |
1172 (52%) |
| Male (%) |
1084 (48%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
32.3 (28.48,36.12) |
| Male |
39.62 (35.01,44.22) |
Incidence stratified by sex
| Female |
1.85 (1.5,2.21) |
| Male |
1.9 (1.51,2.29) |
Incidence stratified by age
| Ages 40-44 |
2.62 (1.61,3.63) |
| Ages 45-49 |
2.31 (1.49,3.12) |
| Ages 50-54 |
2.16 (1.44,2.89) |
| Ages 55-59 |
2.3 (1.62,2.97) |
| Ages 60-64 |
1.39 (0.93,1.84) |
| Ages 65-69 |
1.21 (0.73,1.69) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
40 (34,47) |
51 (45,56) |
41 (37,45) |
| CALIBER |
33 (31,34) |
43 (42,45) |
45 (43,47) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
43(29,60) |
45(34,58) |
36(28,46) |
| Low |
43(29,62) |
52(40,66) |
39(31,49) |
| Medium |
36(23,52) |
44(33,57) |
40(32,51) |
| High |
39(27,55) |
54(42,68) |
38(30,49) |
| Most deprived |
42(31,57) |
59(47,74) |
52(41,64) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
35(29,42) |
52(46,58) |
39(35,44) |
| Scotland |
68(47,97) |
57(42,76) |
46(34,61) |
| Wales |
56(33,90) |
29(16,49) |
53(37,73) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153520, Events=195
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.39 (0.98, 1.99) |
0.068 |
| BMI |
obese |
1.63 (1.11, 2.4) |
0.0126 |
| BMI |
underweight |
0 (0, Inf) |
0.99 |
| smoking |
previous |
1.5 (1.1, 2.03) |
0.00988 |
| smoking |
current |
1.45 (0.93, 2.27) |
0.0986 |
| hypertension |
yes |
1.38 (0.98, 1.93) |
0.0624 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1477 |
psoriatic arthropathy |
| 41202 |
Diagnoses - main ICD10 |
M07.0 |
Distal interphalangeal psoriatic arthropathy |
| 41202 |
Diagnoses - main ICD10 |
M07.1 |
Arthritis mutilans |
| 41202 |
Diagnoses - main ICD10 |
M07.2 |
Psoriatic spondylitis |
| 41202 |
Diagnoses - main ICD10 |
M07.3 |
Other psoriatic arthropathies |
| 41202 |
Diagnoses - main ICD10 |
L40.5 |
Arthropathic psoriasis |
| 41204 |
Diagnoses - secondary ICD10 |
M07.0 |
Distal interphalangeal psoriatic arthropathy |
| 41204 |
Diagnoses - secondary ICD10 |
M07.1 |
Arthritis mutilans |
| 41204 |
Diagnoses - secondary ICD10 |
M07.2 |
Psoriatic spondylitis |
| 41204 |
Diagnoses - secondary ICD10 |
M07.3 |
Other psoriatic arthropathies |
| 41204 |
Diagnoses - secondary ICD10 |
L40.5 |
Arthropathic psoriasis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
M07.0 |
Distal interphalangeal psoriatic arthropathy |
| 40001 |
Underlying (primary) cause of death: ICD10 |
M07.1 |
Arthritis mutilans |
| 40001 |
Underlying (primary) cause of death: ICD10 |
M07.2 |
Psoriatic spondylitis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
M07.3 |
Other psoriatic arthropathies |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L40.5 |
Arthropathic psoriasis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
M07.0 |
Distal interphalangeal psoriatic arthropathy |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
M07.1 |
Arthritis mutilans |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
M07.2 |
Psoriatic spondylitis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
M07.3 |
Other psoriatic arthropathies |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L40.5 |
Arthropathic psoriasis |
| 42040 |
GP clinical event records |
M160000 |
Psoriasis spondylitica |
| 42040 |
GP clinical event records |
M160100 |
Distal interphalangeal psoriatic arthropathy |
| 42040 |
GP clinical event records |
M160200 |
Arthritis mutilans |
| 42040 |
GP clinical event records |
M160.00 |
Psoriatic arthropathy |
| 42040 |
GP clinical event records |
M160.11 |
Psoriatic arthritis |
| 42040 |
GP clinical event records |
M160z00 |
Psoriatic arthropathy NOS |
| 42040 |
GP clinical event records |
Nyu1300 |
[X]Other psoriatic arthropathies |