Psoriasis

Metadata

Name	Psoriasis (psoriasis)
Category	Skin
Sex
Adult	Yes
UUID	bfbc5ef7-0205-43ec-ab05-e6de51ab361d
Definition	A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Ontologies

Disease Ontology (DOID)	DOID_8893
GWAS Catalogue	EFO_0000676
MeSH	D011565
SNOMED-CT	9014002
FinnGen	L12_PSORIASIS

Key Summary Statistics

Cases from any source

Total	15545
Female (%)	7823 (50%)
Male (%)	7722 (50%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	312.96 (301.25,324.68)
Male	370.56 (356.71,384.42)

Incidence stratified by sex

Female	12.94 (11.98,13.89)
Male	13.83 (12.75,14.91)

Incidence stratified by age

Ages 40-44	11.87 (9.69,14.04)
Ages 45-49	11.52 (9.68,13.36)
Ages 50-54	13.05 (11.23,14.86)
Ages 55-59	13.31 (11.64,14.97)
Ages 60-64	14.07 (12.6,15.54)
Ages 65-69	14.63 (12.92,16.35)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	346 (328,365)	376 (362,392)	411 (398,424)
CALIBER	409 (404,414)	464 (458,470)	521 (513,528)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	320(280,365)	348(317,382)	391(364,420)
Low	345(303,391)	365(332,400)	396(369,425)
Medium	345(304,390)	340(309,374)	383(356,413)
High	347(309,388)	417(383,454)	416(386,448)
Most deprived	365(329,403)	408(375,444)	481(448,517)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	328(309,348)	378(361,395)	410(395,425)
Scotland	421(365,483)	356(318,398)	390(354,430)
Wales	424(353,505)	397(345,455)	449(400,502)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153595, Events=126

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.75 (0.51, 1.1)	0.143
BMI	obese	0.53 (0.31, 0.88)	0.014
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	1.05 (0.71, 1.56)	0.804
smoking	current	1.31 (0.76, 2.25)	0.339
hypertension	yes	1.64 (1.09, 2.47)	0.0186

Genetic correlation

Genetic correlation (rg)	P value
0.83	5.14e-63

Published study: Tsoi (2012)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1453	psoriasis
20002	Non-cancer illness code, self-reported	1477	psoriatic arthropathy
41202	Diagnoses - main ICD10	L40	Psoriasis
41202	Diagnoses - main ICD10	M07.0	Distal interphalangeal psoriatic arthropathy
41202	Diagnoses - main ICD10	M07.1	Arthritis mutilans
41202	Diagnoses - main ICD10	M07.2	Psoriatic spondylitis
41202	Diagnoses - main ICD10	M07.3	Other psoriatic arthropathies
41202	Diagnoses - main ICD10	M09.0	Juvenile arthritis in psoriasis
41204	Diagnoses - secondary ICD10	L40	Psoriasis
41204	Diagnoses - secondary ICD10	M07.0	Distal interphalangeal psoriatic arthropathy
41204	Diagnoses - secondary ICD10	M07.1	Arthritis mutilans
41204	Diagnoses - secondary ICD10	M07.2	Psoriatic spondylitis
41204	Diagnoses - secondary ICD10	M07.3	Other psoriatic arthropathies
41204	Diagnoses - secondary ICD10	M09.0	Juvenile arthritis in psoriasis
40001	Underlying (primary) cause of death: ICD10	L40	Psoriasis
40001	Underlying (primary) cause of death: ICD10	M07.0	Distal interphalangeal psoriatic arthropathy
40001	Underlying (primary) cause of death: ICD10	M07.1	Arthritis mutilans
40001	Underlying (primary) cause of death: ICD10	M07.2	Psoriatic spondylitis
40001	Underlying (primary) cause of death: ICD10	M07.3	Other psoriatic arthropathies
40001	Underlying (primary) cause of death: ICD10	M09.0	Juvenile arthritis in psoriasis
40002	Contributory (secondary) causes of death: ICD10	L40	Psoriasis
40002	Contributory (secondary) causes of death: ICD10	M07.0	Distal interphalangeal psoriatic arthropathy
40002	Contributory (secondary) causes of death: ICD10	M07.1	Arthritis mutilans
40002	Contributory (secondary) causes of death: ICD10	M07.2	Psoriatic spondylitis
40002	Contributory (secondary) causes of death: ICD10	M07.3	Other psoriatic arthropathies
40002	Contributory (secondary) causes of death: ICD10	M09.0	Juvenile arthritis in psoriasis
42040	GP clinical event records	14F2.00	H/O: psoriasis
42040	GP clinical event records	M160000	Psoriasis spondylitica
42040	GP clinical event records	M160100	Distal interphalangeal psoriatic arthropathy
42040	GP clinical event records	M160200	Arthritis mutilans
42040	GP clinical event records	M160.00	Psoriatic arthropathy
42040	GP clinical event records	M160.11	Psoriatic arthritis
42040	GP clinical event records	M160z00	Psoriatic arthropathy NOS
42040	GP clinical event records	M161000	Psoriasis unspecified
42040	GP clinical event records	M161100	Psoriasis annularis
42040	GP clinical event records	M161200	Psoriasis circinata
42040	GP clinical event records	M161300	Psoriasis diffusa
42040	GP clinical event records	M161400	Psoriasis discoidea
42040	GP clinical event records	M161500	Psoriasis geographica
42040	GP clinical event records	M161600	Guttate psoriasis
42040	GP clinical event records	M161700	Psoriasis gyrata
42040	GP clinical event records	M161800	Psoriasis inveterata
42040	GP clinical event records	M161900	Psoriasis ostracea
42040	GP clinical event records	M161A00	Psoriasis palmaris
42040	GP clinical event records	M161B00	Psoriasis plantaris
42040	GP clinical event records	M161C00	Psoriasis punctata
42040	GP clinical event records	M161D00	Pustular psoriasis
42040	GP clinical event records	M161E00	Psoriasis universalis
42040	GP clinical event records	M161F00	Psoriasis vulgaris
42040	GP clinical event records	M161F11	Chronic large plaque psoriasis
42040	GP clinical event records	M161H00	Erythrodermic psoriasis
42040	GP clinical event records	M161J00	Flexural psoriasis
42040	GP clinical event records	M161.00	Other psoriasis
42040	GP clinical event records	M161z00	Psoriasis NOS
42040	GP clinical event records	M166.00	Palmoplantar pustular psoriasis
42040	GP clinical event records	M16..00	Psoriasis and similar disorders
42040	GP clinical event records	M16y000	Scalp psoriasis
42040	GP clinical event records	M16y.00	Other psoriasis and similar disorders
42040	GP clinical event records	M16z.00	Psoriasis and similar disorders NOS
42040	GP clinical event records	Myu3000	[X]Other psoriasis
42040	GP clinical event records	N045200	Juvenile arthritis in psoriasis
42040	GP clinical event records	Nyu1300	[X]Other psoriatic arthropathies
42040	GP clinical event records	X506Z	Flexural psoriasis
42040	GP clinical event records	X506m	Palmoplantar pustular psoriasis
42040	GP clinical event records	X506b	Erythrodermic psoriasis
42040	GP clinical event records	XaNXt	Psoriasis vulgaris
42040	GP clinical event records	XaYOx	Pustular psoriasis
42040	GP clinical event records	X506i	Scalp psoriasis