Ptosis of eyelid

Metadata

Name	Ptosis of eyelid (ptosis)
Category	Eye
Sex
Adult	Yes
UUID	dfe017cd-7b88-4eb6-8290-b2ece715b841
Definition	An eye disease characterized by the drooping or falling of the upper or lower eyelid.

Ontologies

Disease Ontology (DOID)	DOID_0060260
GWAS Catalogue	MONDO_0000728
MeSH	D001763
SNOMED-CT	11934000
FinnGen	H7_PTOSIS

Key Summary Statistics

Cases from any source

Total	3313
Female (%)	1999 (60%)
Male (%)	1314 (40%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	37.37 (33.26,41.47)
Male	26.88 (23.08,30.68)

Incidence stratified by sex

Female	4.93 (4.35,5.5)
Male	3.17 (2.66,3.67)

Incidence stratified by age

Ages 40-44	1.51 (0.75,2.27)
Ages 45-49	2.38 (1.55,3.2)
Ages 50-54	2.99 (2.13,3.84)
Ages 55-59	3.96 (3.07,4.86)
Ages 60-64	5.17 (4.29,6.04)
Ages 65-69	6.31 (5.21,7.42)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	28 (23,34)	46 (41,51)	73 (67,79)
CALIBER	24 (23,25)	38 (37,40)	63 (61,66)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	19(11,32)	38(28,50)	74(62,87)
Low	22(12,36)	45(34,57)	71(59,83)
Medium	22(13,36)	40(30,52)	72(61,85)
High	34(23,48)	49(38,62)	73(61,87)
Most deprived	37(27,51)	56(45,70)	76(63,90)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	30(25,37)	50(44,57)	77(71,83)
Scotland	21(10,37)	24(15,36)	56(43,71)
Wales	16(5,39)	38(23,58)	57(41,78)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153508, Events=407

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.96 (0.75, 1.22)	0.716
BMI	obese	1.36 (1.06, 1.76)	0.0167
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.37 (1.1, 1.7)	0.00438
smoking	current	2.14 (1.6, 2.85)	2.26e-07
hypertension	yes	1.88 (1.53, 2.31)	1.47e-09

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	H02.4	Ptosis of eyelid
41204	Diagnoses - secondary ICD10	H02.4	Ptosis of eyelid
41200	Operative procedures - main OPCS4	C18.1	Correction of ptosis of eyelid using levator muscle technique
41200	Operative procedures - main OPCS4	C18.2	Correction of ptosis of eyelid using frontalis muscle technique
41200	Operative procedures - main OPCS4	C18.3	Correction of ptosis of eyelid using sling of fascia
41200	Operative procedures - main OPCS4	C18.4	Correction of ptosis of eyelid using superior rectus muscle technique
41200	Operative procedures - main OPCS4	C18.5	Tarsomullerectomy
41200	Operative procedures - main OPCS4	C18.6	Correction of ptosis of eyelid using aponeurosis technique
41200	Operative procedures - main OPCS4	C18.8	Other specified correction of ptosis of eyelid
41200	Operative procedures - main OPCS4	C18.9	Unspecified correction of ptosis of eyelid
41210	Operative procedures - secondary OPCS4	C18.1	C18.1
41210	Operative procedures - secondary OPCS4	C18.2	C18.2
41210	Operative procedures - secondary OPCS4	C18.3	C18.3
41210	Operative procedures - secondary OPCS4	C18.4	C18.4
41210	Operative procedures - secondary OPCS4	C18.5	C18.5
41210	Operative procedures - secondary OPCS4	C18.6	C18.6
41210	Operative procedures - secondary OPCS4	C18.8	C18.8
41210	Operative procedures - secondary OPCS4	C18.9	C18.9
40001	Underlying (primary) cause of death: ICD10	H02.4	Ptosis of eyelid
40002	Contributory (secondary) causes of death: ICD10	H02.4	Ptosis of eyelid
42040	GP clinical event records	2BE2.00	O/E - ptosis present
42040	GP clinical event records	2BE..00	O/E - ptosis
42040	GP clinical event records	2BE3.00	O/E - Horner’s syndrome
42040	GP clinical event records	2BEZ.00	O/E - ptosis NOS
42040	GP clinical event records	7218000.0	Correction of eyelid ptosis using levator muscle technique
42040	GP clinical event records	7218100.0	Correction of eyelid ptosis using frontalis muscle technique
42040	GP clinical event records	7218200.0	Correction of ptosis of eyelid using sling of fascia
42040	GP clinical event records	7218300.0	Correction of eyelid ptosis using superior rectus technique
42040	GP clinical event records	7218500.0	Correction of eyelid ptosis using aponeurosis technique
42040	GP clinical event records	7218.00	Correction of ptosis of eyelid
42040	GP clinical event records	7218y00	Other specified correction of ptosis of eyelid
42040	GP clinical event records	7218z00	Correction of ptosis of eyelid NOS
42040	GP clinical event records	F4E3000	Unspecified ptosis of eyelid
42040	GP clinical event records	F4E3100	Paralytic ptosis
42040	GP clinical event records	F4E3200	Myogenic ptosis
42040	GP clinical event records	F4E3300	Mechanical ptosis
42040	GP clinical event records	F4E3.00	Ptosis of eyelid
42040	GP clinical event records	F4E3z00	Ptosis of eyelid NOS
42040	GP clinical event records	P360.00	Congenital ptosis
42040	GP clinical event records	P360.11	Blepharoptosis
42040	GP clinical event records	XE1Jz	Congenital ptosis
42040	GP clinical event records	XE0B4	Correction of ptosis of eyelid using sling of fascia
42040	GP clinical event records	XM050	Ptosis of eyelid