| Name |
Right bundle branch block (RBBB) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
4b9f0e19-0881-4f93-a6c6-fd312f3f2305 |
| Definition |
A heart block in the right bundle branch of the electrical conduction system. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
5656 |
| Female (%) |
1729 (31%) |
| Male (%) |
3927 (69%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
11.79 (9.48,14.1) |
| Male |
31.78 (27.65,35.91) |
Incidence stratified by sex
| Female |
3.4 (2.92,3.88) |
| Male |
8.9 (8.05,9.75) |
Incidence stratified by age
| Ages 40-44 |
1.91 (1.05,2.77) |
| Ages 45-49 |
2.3 (1.49,3.11) |
| Ages 50-54 |
3.17 (2.29,4.05) |
| Ages 55-59 |
5.37 (4.33,6.4) |
| Ages 60-64 |
7.01 (5.99,8.03) |
| Ages 65-69 |
11.57 (10.07,13.07) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
26 (21,32) |
38 (34,44) |
83 (77,89) |
| CALIBER |
17 (16,18) |
34 (32,35) |
72 (69,75) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
26(15,41) |
33(24,45) |
70(58,83) |
| Low |
24(13,39) |
37(27,50) |
76(64,90) |
| Medium |
26(16,41) |
41(30,54) |
88(75,102) |
| High |
35(23,50) |
36(26,49) |
81(68,96) |
| Most deprived |
19(11,29) |
45(34,58) |
102(86,119) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
28(22,34) |
41(35,47) |
87(80,94) |
| Scotland |
12(4,26) |
21(13,34) |
61(47,78) |
| Wales |
30(14,57) |
42(26,65) |
74(55,98) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154060, Events=218
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.89 (0.65, 1.23) |
0.488 |
| BMI |
obese |
1.16 (0.82, 1.63) |
0.404 |
| BMI |
underweight |
0 (0, Inf) |
0.989 |
| smoking |
previous |
1.75 (1.31, 2.35) |
0.000182 |
| smoking |
current |
2.37 (1.58, 3.55) |
3.07e-05 |
| hypertension |
yes |
1 (0.74, 1.36) |
0.997 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
I45.1 |
Other and unspecified right bundle-branch block |
| 41204 |
Diagnoses - secondary ICD10 |
I45.1 |
Other and unspecified right bundle-branch block |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I45.1 |
Other and unspecified right bundle-branch block |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I45.1 |
Other and unspecified right bundle-branch block |
| 42040 |
GP clinical event records |
3299.00 |
ECG: right bundle branch block |
| 42040 |
GP clinical event records |
G564.00 |
Right bundle branch block |
| 42040 |
GP clinical event records |
G566200 |
Right fascicular block |
| 42040 |
GP clinical event records |
G56y400 |
Right fascicular block |
| 42040 |
GP clinical event records |
Gyu5W00 |
[X]Other and unspecified right bundle-branch block |