Postinfective and reactive arthropathies

Metadata

Name	Postinfective and reactive arthropathies (reactive)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	88814ec7-4ffd-4d10-9407-5cc62aece4e3
Definition	An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the gastrointestinal tract or urogenital system..

Ontologies

Disease Ontology (DOID)	DOID_6196
MeSH	D016918
SNOMED-CT	201736002
FinnGen	M13_REACTARTH

Key Summary Statistics

Cases from any source

Total	390
Female (%)	159 (41%)
Male (%)	231 (59%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	6.13 (4.46,7.8)
Male	12.74 (10.12,15.36)

Incidence stratified by sex

Female	0.21 (0.09,0.33)
Male	0.46 (0.27,0.66)

Incidence stratified by age

Ages 40-44	0.0 (0.0,0.0)
Ages 45-49	0.3 (0.01,0.59)
Ages 50-54	0.51 (0.16,0.86)
Ages 55-59	0.36 (0.09,0.63)
Ages 60-64	0.42 (0.17,0.67)
Ages 65-69	0.2 (0.0,0.4)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	10 (7,14)	12 (10,15)	12 (10,15)
CALIBER	14 (13,15)	16 (15,17)	15 (14,16)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	17(8,30)	9(5,16)	12(8,18)
Low	9(3,20)	10(5,17)	15(10,21)
Medium	5(1,13)	13(7,21)	13(8,19)
High	8(3,17)	11(6,19)	12(7,19)
Most deprived	12(6,21)	18(11,27)	10(5,16)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	10(7,15)	14(11,18)	13(11,16)
Scotland	7(2,19)	4(1,10)	8(4,16)
Wales	11(2,32)	10(4,23)	11(5,22)

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	M02	Reactive arthropathies
41202	Diagnoses - main ICD10	M03	Postinfective and reactive arthropathies in diseases classified elsewhere
41204	Diagnoses - secondary ICD10	M02	Reactive arthropathies
41204	Diagnoses - secondary ICD10	M03	Postinfective and reactive arthropathies in diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	M02	Reactive arthropathies
40001	Underlying (primary) cause of death: ICD10	M03	Postinfective and reactive arthropathies in diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	M02	Reactive arthropathies
40002	Contributory (secondary) causes of death: ICD10	M03	Postinfective and reactive arthropathies in diseases classified elsewhere
42040	GP clinical event records	A993.00	Reiter’s disease / syndrome
42040	GP clinical event records	A993.11	Reiter’s syndrome
42040	GP clinical event records	M211400	Keratoderma blennorrhagica
42040	GP clinical event records	N011400	Sexually acquired reactive arthropathy of the hand
42040	GP clinical event records	N011600	Sexually acquired reactive arthropathy of the lower leg
42040	GP clinical event records	N011.00	Sexually acquired reactive arthropathy
42040	GP clinical event records	N011.12	Arthropathy in Reiter’s disease
42040	GP clinical event records	N011x00	Sexually acquired reactive arthropathy of multiple sites
42040	GP clinical event records	N011z00	Sexually acquired reactive arthropathy NOS
42040	GP clinical event records	N013400	Postdysenteric reactive arthropathy of the hand
42040	GP clinical event records	N013700	Postdysenteric reactive arthropathy of the ankle and foot
42040	GP clinical event records	N013.00	Postdysenteric reactive arthropathy
42040	GP clinical event records	N013x00	Postdysenteric reactive arthropathy of multiple sites
42040	GP clinical event records	N01w000	Reactive arthropathy of shoulder
42040	GP clinical event records	N01w100	Reactive arthropathy of sternoclavicular joint
42040	GP clinical event records	N01w300	Reactive arthropathy of elbow
42040	GP clinical event records	N01w500	Reactive arthropathy of wrist
42040	GP clinical event records	N01w600	Reactive arthropathy of MCP joint
42040	GP clinical event records	N01w700	Reactive arthropathy of PIP joint of finger
42040	GP clinical event records	N01w800	Reactive arthropathy of DIP joint of finger
42040	GP clinical event records	N01w900	Reactive arthropathy of hip
42040	GP clinical event records	N01wA00	Reactive arthropathy of sacro-iliac joint
42040	GP clinical event records	N01wB00	Reactive arthropathy of knee
42040	GP clinical event records	N01wD00	Reactive arthropathy of ankle
42040	GP clinical event records	N01wH00	Reactive arthropathy of 1st MTP joint
42040	GP clinical event records	N01wJ00	Reactive arthropathy of lesser MTP joint
42040	GP clinical event records	N01wK00	Reactive arthropathy of IP joint of toe
42040	GP clinical event records	N01w.00	Reactive arthropathy, unspecified
42040	GP clinical event records	N038.00	Reactive arthropathies
42040	GP clinical event records	Nyu0300	[X]Other reactive arthropathies
42040	GP clinical event records	Nyu0400	[X]Other postinfectious arthropathies in diseases CE
42040	GP clinical event records	Nyu0500	[X]Reactive arthropathy in other diseases CE