| Name |
Respiratory failure (resp_failure) |
| Category |
Respiratory |
| Sex |
|
| Adult |
Yes |
| UUID |
ff99bdd2-a8b4-4c9f-bca3-b8cedc8901e3 |
| Definition |
The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
7848 |
| Female (%) |
3262 (42%) |
| Male (%) |
4586 (58%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
5.19 (3.65,6.72) |
| Male |
11.9 (9.37,14.43) |
Incidence stratified by sex
| Female |
4.8 (4.23,5.37) |
| Male |
9.4 (8.53,10.28) |
Incidence stratified by age
| Ages 40-44 |
1.81 (0.97,2.65) |
| Ages 45-49 |
2.97 (2.05,3.89) |
| Ages 50-54 |
3.93 (2.95,4.91) |
| Ages 55-59 |
5.83 (4.75,6.9) |
| Ages 60-64 |
8.85 (7.7,9.99) |
| Ages 65-69 |
12.93 (11.35,14.51) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
15 (12,20) |
34 (29,38) |
69 (64,75) |
| CALIBER |
29 (28,31) |
64 (61,66) |
147 (143,150) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
10(4,21) |
17(11,26) |
41(32,51) |
| Low |
10(4,22) |
25(17,36) |
52(42,63) |
| Medium |
16(8,29) |
29(20,40) |
52(42,64) |
| High |
6(2,14) |
21(14,31) |
76(63,90) |
| Most deprived |
28(19,41) |
74(60,90) |
137(119,156) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
16(12,21) |
37(32,43) |
73(67,80) |
| Scotland |
10(3,24) |
18(10,29) |
32(22,45) |
| Wales |
13(4,34) |
24(12,42) |
78(59,102) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153513, Events=116
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.85 (1.14, 2.99) |
0.0128 |
| BMI |
obese |
1.9 (1.12, 3.22) |
0.0174 |
| BMI |
underweight |
0 (0, Inf) |
0.993 |
| smoking |
previous |
0.82 (0.53, 1.27) |
0.367 |
| smoking |
current |
1.79 (1.09, 2.95) |
0.0215 |
| hypertension |
yes |
1.55 (1.01, 2.37) |
0.0432 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1124 |
respiratory failure |
| 41202 |
Diagnoses - main ICD10 |
J96 |
Respiratory failure, not elsewhere classified |
| 41204 |
Diagnoses - secondary ICD10 |
J96 |
Respiratory failure, not elsewhere classified |
| 40001 |
Underlying (primary) cause of death: ICD10 |
J96 |
Respiratory failure, not elsewhere classified |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
J96 |
Respiratory failure, not elsewhere classified |
| 42040 |
GP clinical event records |
Fy04.00 |
Sleep-related respiratory failure |
| 42040 |
GP clinical event records |
H590.00 |
Acute respiratory failure |
| 42040 |
GP clinical event records |
H591.00 |
Chronic respiratory failure |
| 42040 |
GP clinical event records |
H592.00 |
Chronic type 1 respiratory failure |
| 42040 |
GP clinical event records |
H593.00 |
Chronic type 2 respiratory failure |
| 42040 |
GP clinical event records |
H59..00 |
Respiratory failure |
| 42040 |
GP clinical event records |
R2y1.00 |
[D]Respiratory failure |
| 42040 |
GP clinical event records |
R2y1z00 |
[D]Respiratory failure NOS |
| 42040 |
GP clinical event records |
X008F |
Sleep-related respiratory failure |
| 42040 |
GP clinical event records |
XaO5l |
Chronic type 1 respiratory failure |
| 42040 |
GP clinical event records |
XM09V |
Respiratory failure |
| 42040 |
GP clinical event records |
XaO5m |
Chronic type 2 respiratory failure |