Retinal detachments and breaks

Metadata

Name	Retinal detachments and breaks (retinal_detach)
Category	Eye
Sex
Adult	Yes
UUID	06cbf134-cb89-4c8d-9741-b38a337752b6
Definition	Retinal detachment is a disorder of the eye in which the retina separates from the layer underneath.

Ontologies

Disease Ontology (DOID)	DOID_5327
GWAS Catalogue	EFO_0005773
MeSH	D012163
SNOMED-CT	42059000
FinnGen	H7_RETINALDETACH

Key Summary Statistics

Cases from any source

Total	7012
Female (%)	3030 (43%)
Male (%)	3982 (57%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	66.13 (60.67,71.58)
Male	101.64 (94.28,108.99)

Incidence stratified by sex

Female	6.09 (5.45,6.74)
Male	8.35 (7.53,9.18)

Incidence stratified by age

Ages 40-44	3.13 (2.03,4.23)
Ages 45-49	4.17 (3.08,5.27)
Ages 50-54	6.05 (4.84,7.27)
Ages 55-59	9.77 (8.36,11.17)
Ages 60-64	8.21 (7.1,9.32)
Ages 65-69	8.0 (6.75,9.26)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	45 (38,52)	89 (82,97)	147 (139,155)
CALIBER	37 (36,39)	72 (70,75)	128 (124,132)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	50(35,69)	79(64,96)	141(125,159)
Low	48(33,67)	90(74,109)	150(134,169)
Medium	40(27,58)	95(79,114)	157(140,176)
High	43(30,59)	94(78,112)	156(138,176)
Most deprived	44(32,59)	88(72,105)	125(108,144)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	44(37,52)	90(82,99)	150(142,160)
Scotland	39(23,60)	85(67,106)	122(102,146)
Wales	61(37,96)	87(64,117)	143(116,175)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153508, Events=407

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.96 (0.75, 1.22)	0.716
BMI	obese	1.36 (1.06, 1.76)	0.0167
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.37 (1.1, 1.7)	0.00438
smoking	current	2.14 (1.6, 2.85)	2.26e-07
hypertension	yes	1.88 (1.53, 2.31)	1.47e-09

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1281	retinal detachment
41202	Diagnoses - main ICD10	H33.0	Retinal detachment with retinal break
41202	Diagnoses - main ICD10	H33.3	Retinal breaks without detachment
41202	Diagnoses - main ICD10	H33.4	Traction detachment of retina
41202	Diagnoses - main ICD10	H33.5	Other retinal detachments
41204	Diagnoses - secondary ICD10	H33.0	Retinal detachment with retinal break
41204	Diagnoses - secondary ICD10	H33.3	Retinal breaks without detachment
41204	Diagnoses - secondary ICD10	H33.4	Traction detachment of retina
41204	Diagnoses - secondary ICD10	H33.5	Other retinal detachments
41200	Operative procedures - main OPCS4	C81	Photocoagulation of retina for detachment
41200	Operative procedures - main OPCS4	C81.1	Xenon photocoagulation of retina for detachment
41200	Operative procedures - main OPCS4	C81.2	Laser photocoagulation of retina for detachment
41200	Operative procedures - main OPCS4	C81.8	Other specified photocoagulation of retina for detachment
41200	Operative procedures - main OPCS4	C81.9	Unspecified photocoagulation of retina for detachment
41210	Operative procedures - secondary OPCS4	C81	C81
41210	Operative procedures - secondary OPCS4	C81.1	C81.1
41210	Operative procedures - secondary OPCS4	C81.2	C81.2
41210	Operative procedures - secondary OPCS4	C81.8	C81.8
41210	Operative procedures - secondary OPCS4	C81.9	C81.9
40001	Underlying (primary) cause of death: ICD10	H33.0	Retinal detachment with retinal break
40001	Underlying (primary) cause of death: ICD10	H33.3	Retinal breaks without detachment
40001	Underlying (primary) cause of death: ICD10	H33.4	Traction detachment of retina
40001	Underlying (primary) cause of death: ICD10	H33.5	Other retinal detachments
40002	Contributory (secondary) causes of death: ICD10	H33.0	Retinal detachment with retinal break
40002	Contributory (secondary) causes of death: ICD10	H33.3	Retinal breaks without detachment
40002	Contributory (secondary) causes of death: ICD10	H33.4	Traction detachment of retina
40002	Contributory (secondary) causes of death: ICD10	H33.5	Other retinal detachments
42040	GP clinical event records	1481.00	H/O: retinal detachment
42040	GP clinical event records	7271000.0	Xenon photocoagulation of retina for detachment
42040	GP clinical event records	7271100.0	Laser photocoagulation of retina for detachment
42040	GP clinical event records	7271.00	Photocoagulation of retina for detachment
42040	GP clinical event records	7271y00	Other specified photocoagulation of retina for detachment
42040	GP clinical event records	7271z00	Photocoagulation of retina for detachment NOS
42040	GP clinical event records	F410000	Unspecified retinal detachment with retinal defect
42040	GP clinical event records	F410100	New partial retinal detachment with single defect
42040	GP clinical event records	F410200	New partial retinal detachment with multiple defects
42040	GP clinical event records	F410300	New partial retinal detachment with giant tear defect
42040	GP clinical event records	F410400	New partial retinal detachment with retinal dialysis
42040	GP clinical event records	F410500	Recent total retinal detachment
42040	GP clinical event records	F410600	Recent subtotal retinal detachment
42040	GP clinical event records	F410700	Old partial retinal detachment
42040	GP clinical event records	F410800	Old total retinal detachment
42040	GP clinical event records	F410900	Old subtotal retinal detachment
42040	GP clinical event records	F410.00	Retinal detachment with retinal defect
42040	GP clinical event records	F410z00	Retinal detachment with defect NOS
42040	GP clinical event records	F413100	Retinal round hole without detachment
42040	GP clinical event records	F413200	Horseshoe retinal tear without detachment
42040	GP clinical event records	F413300	Multiple retinal defects without detachment
42040	GP clinical event records	F413400	Retinal break
42040	GP clinical event records	F413.00	Retinal defects without detachment
42040	GP clinical event records	F413z00	Retinal defects without detachment NOS
42040	GP clinical event records	F41..00	Retinal detachments and defects
42040	GP clinical event records	F41..11	Retinal tears
42040	GP clinical event records	F41y000	Traction retinal detachment
42040	GP clinical event records	F41y.00	Other forms of retinal detachment
42040	GP clinical event records	F41yz00	Other retinal detachments NOS
42040	GP clinical event records	F41z.00	Retinal detachment NOS
42040	GP clinical event records	FyuF400	[X]Other retinal detachments
42040	GP clinical event records	XE15s	Retinal detachments and defects
42040	GP clinical event records	X00cx	Retinal break