Metadata
| Name | Retinal vascular occlusions (retinal_vasc_occl) |
| Category | Eye |
| Sex | |
| Adult | Yes |
| UUID | 35f55084-0c1c-4688-aab1-1e900819461e |
| Definition | Blockage of the RETINAL VEIN. |
Ontologies
| Disease Ontology (DOID) | DOID_1729 |
| GWAS Catalogue | EFO_1001157 |
| MeSH | D012170 |
| SNOMED-CT | 73757007 |
| FinnGen | H7_RETIVASCOCCLUSION |
Key Summary Statistics
Cases from any source
| Total | 2497 |
| Female (%) | 1089 (44%) |
| Male (%) | 1408 (56%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 19.21 (16.27,22.16) |
| Male | 38.92 (34.35,43.48) |
Incidence stratified by sex
| Female | 3.33 (2.85,3.8) |
| Male | 4.69 (4.08,5.31) |
Incidence stratified by age
| Ages 40-44 | 1.31 (0.6,2.02) |
| Ages 45-49 | 1.19 (0.61,1.77) |
| Ages 50-54 | 1.71 (1.07,2.36) |
| Ages 55-59 | 3.49 (2.66,4.33) |
| Ages 60-64 | 5.13 (4.26,6.0) |
| Ages 65-69 | 7.84 (6.61,9.08) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 13 (9,17) | 30 (26,34) | 75 (69,81) |
| CALIBER | 9 (8,10) | 27 (25,28) | 71 (69,74) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 13(6,25) | 26(18,36) | 78(66,91) |
| Low | 12(5,24) | 29(21,41) | 80(68,94) |
| Medium | 11(5,22) | 28(19,39) | 67(56,80) |
| High | 17(9,29) | 28(20,39) | 74(61,88) |
| Most deprived | 10(5,18) | 37(27,49) | 73(61,88) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 13(9,18) | 30(25,35) | 73(67,80) |
| Scotland | 10(3,24) | 28(18,42) | 80(64,100) |
| Wales | 10(2,29) | 29(16,49) | 81(61,106) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.96 (0.75, 1.22) | 0.716 |
| BMI | obese | 1.36 (1.06, 1.76) | 0.0167 |
| BMI | underweight | 0 (0, Inf) | 0.986 |
| smoking | previous | 1.37 (1.1, 1.7) | 0.00438 |
| smoking | current | 2.14 (1.6, 2.85) | 2.26e-07 |
| hypertension | yes | 1.88 (1.53, 2.31) | 1.47e-09 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1282 | retinal artery/vein occlusion |
| 41202 | Diagnoses - main ICD10 | H34 | Retinal vascular occlusions |
| 41204 | Diagnoses - secondary ICD10 | H34 | Retinal vascular occlusions |
| 40001 | Underlying (primary) cause of death: ICD10 | H34 | Retinal vascular occlusions |
| 40002 | Contributory (secondary) causes of death: ICD10 | H34 | Retinal vascular occlusions |
| 42040 | GP clinical event records | F423000 | Unspecified retinal vascular occlusion |
| 42040 | GP clinical event records | F423100 | Central retinal artery occlusion |
| 42040 | GP clinical event records | F423200 | Retinal arterial branch occlusion |
| 42040 | GP clinical event records | F423211 | Branch retinal artery occlusion |
| 42040 | GP clinical event records | F423300 | Retinal microembolism |
| 42040 | GP clinical event records | F423400 | Hollenhorst plaque |
| 42040 | GP clinical event records | F423500 | Retinal partial arterial occlusion NOS |
| 42040 | GP clinical event records | F423700 | Retinal transient arterial occlusion NOS |
| 42040 | GP clinical event records | F423800 | Central retinal vein occlusion |
| 42040 | GP clinical event records | F423811 | Retinal vein thrombosis |
| 42040 | GP clinical event records | F423900 | Retinal venous branch occlusion |
| 42040 | GP clinical event records | F423911 | Branch retinal vein occlusion |
| 42040 | GP clinical event records | F423A00 | Retinal venous engorgement |
| 42040 | GP clinical event records | F423.00 | Retinal vascular occlusion |
| 42040 | GP clinical event records | F423z00 | Retinal vascular occlusion NOS |
| 42040 | GP clinical event records | F42y700 | Retinal cotton wool spots |
| 42040 | GP clinical event records | FyuF500 | [X]Other retinal artery occlusions |
| 42040 | GP clinical event records | FyuF600 | [X]Other retinal vascular occlusions |
| 42040 | GP clinical event records | XE15w | Central retinal vein occlusion |