Rheumatic valve dz

Metadata

Name	Rheumatic valve dz (Rh_valve)
Category	Cardiovascular
Sex
Adult	Yes
UUID	6c8b726f-7f44-4a10-95ed-db981999e94c
Definition	A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage.

Ontologies

Disease Ontology (DOID)	DOID_0050827
GWAS Catalogue	EFO_1001161
MeSH	D012214
SNOMED-CT	16063004
FinnGen	I9_RHEUVALV

Key Summary Statistics

Cases from any source

Total	2317
Female (%)	1201 (52%)
Male (%)	1116 (48%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	15.56 (12.91,18.21)
Male	9.24 (7.01,11.47)

Incidence stratified by sex

Female	1.46 (1.15,1.77)
Male	1.85 (1.47,2.24)

Incidence stratified by age

Ages 40-44	0.6 (0.12,1.09)
Ages 45-49	0.59 (0.18,1.0)
Ages 50-54	0.76 (0.33,1.19)
Ages 55-59	1.2 (0.71,1.69)
Ages 60-64	1.85 (1.32,2.37)
Ages 65-69	3.72 (2.88,4.57)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	5 (3,8)	14 (11,17)	32 (29,36)
CALIBER	6 (6,7)	14 (12,15)	34 (32,36)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	5(1,14)	12(7,19)	28(21,36)
Low	0(NaN,NaN)	10(5,17)	30(23,39)
Medium	5(1,14)	10(5,17)	29(22,38)
High	5(2,13)	12(7,19)	29(21,38)
Most deprived	9(4,16)	25(17,34)	47(37,59)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	5(3,9)	13(10,16)	31(27,35)
Scotland	3(0,12)	18(10,28)	37(26,50)
Wales	6(1,22)	15(6,29)	39(26,57)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=154060, Events=218

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.65, 1.23)	0.488
BMI	obese	1.16 (0.82, 1.63)	0.404
BMI	underweight	0 (0, Inf)	0.989
smoking	previous	1.75 (1.31, 2.35)	0.000182
smoking	current	2.37 (1.58, 3.55)	3.07e-05
hypertension	yes	1 (0.74, 1.36)	0.997

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1489	mitral stenosis
41202	Diagnoses - main ICD10	I05	Rheumatic mitral valve diseases
41202	Diagnoses - main ICD10	I06	Rheumatic aortic valve diseases
41202	Diagnoses - main ICD10	I07	Rheumatic tricuspid valve diseases
41204	Diagnoses - secondary ICD10	I05	Rheumatic mitral valve diseases
41204	Diagnoses - secondary ICD10	I06	Rheumatic aortic valve diseases
41204	Diagnoses - secondary ICD10	I07	Rheumatic tricuspid valve diseases
40001	Underlying (primary) cause of death: ICD10	I05	Rheumatic mitral valve diseases
40001	Underlying (primary) cause of death: ICD10	I06	Rheumatic aortic valve diseases
40001	Underlying (primary) cause of death: ICD10	I07	Rheumatic tricuspid valve diseases
40002	Contributory (secondary) causes of death: ICD10	I05	Rheumatic mitral valve diseases
40002	Contributory (secondary) causes of death: ICD10	I06	Rheumatic aortic valve diseases
40002	Contributory (secondary) causes of death: ICD10	I07	Rheumatic tricuspid valve diseases
42040	GP clinical event records	G110.00	Mitral stenosis
42040	GP clinical event records	G110.11	Rheumatic mitral stenosis
42040	GP clinical event records	G111.00	Rheumatic mitral insufficiency
42040	GP clinical event records	G111.11	Mitral incompetence - rheumatic
42040	GP clinical event records	G111.12	Mitral regurgitation - rheumatic
42040	GP clinical event records	G112.00	Mitral stenosis with insufficiency
42040	GP clinical event records	G112.12	Mitral stenosis with incompetence
42040	GP clinical event records	G112.13	Mitral stenosis with regurgitation
42040	GP clinical event records	G11..11	Rheumatic mitral valve disease
42040	GP clinical event records	G120.00	Rheumatic aortic stenosis
42040	GP clinical event records	G121.00	Rheumatic aortic insufficiency
42040	GP clinical event records	G121.11	Aortic incompetence - rheumatic
42040	GP clinical event records	G121.12	Aortic regurgitation - rheumatic
42040	GP clinical event records	G122.00	Rheumatic aortic stenosis with insufficiency
42040	GP clinical event records	G12..00	Rheumatic aortic valve disease
42040	GP clinical event records	G12z.00	Rheumatic aortic valve disease NOS
42040	GP clinical event records	G140000	Rheumatic tricuspid stenosis
42040	GP clinical event records	G140100	Rheumatic tricuspid insufficiency
42040	GP clinical event records	G140111	Tricuspid regurgitation - rheumatic
42040	GP clinical event records	G140112	Tricuspid incompetence - rheumatic
42040	GP clinical event records	G140200	Rheumatic tricuspid stenosis and insufficiency
42040	GP clinical event records	G14021X	Rheumatic tricuspid stenosis and regurgitation
42040	GP clinical event records	G14021Y	Rheumatic tricuspid stenosis and incompetence
42040	GP clinical event records	G140z00	Rheumatic tricuspid valve disease NOS
42040	GP clinical event records	G141000	Rheumatic pulmonary stenosis
42040	GP clinical event records	G141100	Rheumatic pulmonary insufficiency
42040	GP clinical event records	G141200	Rheumatic pulmonary stenosis and insufficiency
42040	GP clinical event records	G141.00	Rheumatic pulmonary valve disease
42040	GP clinical event records	G141z00	Rheumatic pulmonary valve disease NOS
42040	GP clinical event records	G14z.11	Rheumatic valvulitis, chronic NOS
42040	GP clinical event records	Gyu1100	[X]Other rheumatic aortic valve diseases
42040	GP clinical event records	XE0Ua	Rheumatic endocarditis NOS
42040	GP clinical event records	XE0UZ	Mitral stenosis