Rheumatoid Arthritis

Metadata

Name	Rheumatoid Arthritis (RhA)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	bee64bab-15f0-4c68-a786-aa7048d45cbe
Definition	An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.

Ontologies

Disease Ontology (DOID)	DOID_7148
GWAS Catalogue	EFO_0000685
MeSH	D001172
SNOMED-CT	69896004
FinnGen	M13_RHEUMA

Key Summary Statistics

Cases from any source

Total	12886
Female (%)	8697 (67%)
Male (%)	4189 (33%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	194.97 (185.66,204.27)
Male	111.43 (103.74,119.13)

Incidence stratified by sex

Female	10.35 (9.5,11.19)
Male	6.82 (6.07,7.57)

Incidence stratified by age

Ages 40-44	3.35 (2.21,4.49)
Ages 45-49	6.6 (5.22,7.98)
Ages 50-54	7.07 (5.75,8.39)
Ages 55-59	9.32 (7.95,10.7)
Ages 60-64	9.64 (8.44,10.85)
Ages 65-69	12.5 (10.93,14.07)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	79 (71,88)	149 (140,158)	211 (202,221)
CALIBER	80 (77,82)	149 (146,153)	240 (235,245)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	74(56,96)	115(98,135)	180(162,199)
Low	69(52,91)	121(103,141)	183(165,203)
Medium	60(44,79)	150(130,172)	193(174,214)
High	84(66,104)	149(130,171)	233(211,257)
Most deprived	100(82,121)	208(185,234)	284(259,312)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	74(65,84)	144(134,155)	207(196,217)
Scotland	93(69,123)	153(128,180)	201(175,229)
Wales	107(73,151)	192(157,233)	281(243,323)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153520, Events=195

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.39 (0.98, 1.99)	0.068
BMI	obese	1.63 (1.11, 2.4)	0.0126
BMI	underweight	0 (0, Inf)	0.99
smoking	previous	1.5 (1.1, 2.03)	0.00988
smoking	current	1.45 (0.93, 2.27)	0.0986
hypertension	yes	1.38 (0.98, 1.93)	0.0624

Genetic correlation

Genetic correlation (rg)	P value
0.76	1.32e-30

Published study: Okada (2014)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1464	rheumatoid arthritis
41202	Diagnoses - main ICD10	J99.0	Rheumatoid lung disease
41202	Diagnoses - main ICD10	M05	Seropositive rheumatoid arthritis
41202	Diagnoses - main ICD10	M06	Other rheumatoid arthritis
41204	Diagnoses - secondary ICD10	J99.0	Rheumatoid lung disease
41204	Diagnoses - secondary ICD10	M05	Seropositive rheumatoid arthritis
41204	Diagnoses - secondary ICD10	M06	Other rheumatoid arthritis
40001	Underlying (primary) cause of death: ICD10	J99.0	Rheumatoid lung disease
40001	Underlying (primary) cause of death: ICD10	M05	Seropositive rheumatoid arthritis
40001	Underlying (primary) cause of death: ICD10	M06	Other rheumatoid arthritis
40002	Contributory (secondary) causes of death: ICD10	J99.0	Rheumatoid lung disease
40002	Contributory (secondary) causes of death: ICD10	M05	Seropositive rheumatoid arthritis
40002	Contributory (secondary) causes of death: ICD10	M06	Other rheumatoid arthritis
42040	GP clinical event records	14G1.00	H/O: rheumatoid arthritis
42040	GP clinical event records	2G25.00	O/E - hands - ulnar deviation
42040	GP clinical event records	2G25.11	O/E - ulnar deviation
42040	GP clinical event records	2G27.00	O/E-hands-rheumatoid spindling
42040	GP clinical event records	66H..13	Rheumatoid arthrit. monitoring
42040	GP clinical event records	7P20300	Delivery of rehabilitation for rheumatoid arthritis
42040	GP clinical event records	9mM0.00	Rheumatoid arthritis monitoring invitation first letter
42040	GP clinical event records	9mM1.00	Rheumatoid arthritis monitoring invitation second letter
42040	GP clinical event records	9mM2.00	Rheumatoid arthritis monitoring invitation third letter
42040	GP clinical event records	9mM3.00	Rheumatoid arthritis monitoring verbal invitation
42040	GP clinical event records	9mM4.00	Rheumatoid arthritis monitoring telephone invitation
42040	GP clinical event records	9mM..00	Rheumatoid arthritis monitoring invitation
42040	GP clinical event records	F371200	Polyneuropathy in rheumatoid arthritis
42040	GP clinical event records	F396400	Myopathy due to rheumatoid arthritis
42040	GP clinical event records	G5y8.00	Rheumatoid myocarditis
42040	GP clinical event records	G5yA.00	Rheumatoid carditis
42040	GP clinical event records	H570.00	Rheumatoid lung
42040	GP clinical event records	N362200	Swan-neck finger deformity
42040	GP clinical event records	N040000	Rheumatoid arthritis of cervical spine
42040	GP clinical event records	N040100	Other rheumatoid arthritis of spine
42040	GP clinical event records	N040200	Rheumatoid arthritis of shoulder
42040	GP clinical event records	N040300	Rheumatoid arthritis of sternoclavicular joint
42040	GP clinical event records	N040400	Rheumatoid arthritis of acromioclavicular joint
42040	GP clinical event records	N040500	Rheumatoid arthritis of elbow
42040	GP clinical event records	N040600	Rheumatoid arthritis of distal radio-ulnar joint
42040	GP clinical event records	N040700	Rheumatoid arthritis of wrist
42040	GP clinical event records	N040800	Rheumatoid arthritis of MCP joint
42040	GP clinical event records	N040900	Rheumatoid arthritis of PIP joint of finger
42040	GP clinical event records	N040A00	Rheumatoid arthritis of DIP joint of finger
42040	GP clinical event records	N040B00	Rheumatoid arthritis of hip
42040	GP clinical event records	N040C00	Rheumatoid arthritis of sacro-iliac joint
42040	GP clinical event records	N040D00	Rheumatoid arthritis of knee
42040	GP clinical event records	N040E00	Rheumatoid arthritis of tibio-fibular joint
42040	GP clinical event records	N040F00	Rheumatoid arthritis of ankle
42040	GP clinical event records	N040G00	Rheumatoid arthritis of subtalar joint
42040	GP clinical event records	N040H00	Rheumatoid arthritis of talonavicular joint
42040	GP clinical event records	N040J00	Rheumatoid arthritis of other tarsal joint
42040	GP clinical event records	N040K00	Rheumatoid arthritis of 1st MTP joint
42040	GP clinical event records	N040L00	Rheumatoid arthritis of lesser MTP joint
42040	GP clinical event records	N040M00	Rheumatoid arthritis of IP joint of toe
42040	GP clinical event records	N040.00	Rheumatoid arthritis
42040	GP clinical event records	N040N00	Rheumatoid vasculitis
42040	GP clinical event records	N040P00	Seronegative rheumatoid arthritis
42040	GP clinical event records	N040Q00	Rheumatoid bursitis
42040	GP clinical event records	N040R00	Rheumatoid nodule
42040	GP clinical event records	N040S00	Rheumatoid arthritis - multiple joint
42040	GP clinical event records	N040T00	Flare of rheumatoid arthritis
42040	GP clinical event records	N041.00	Felty’s syndrome
42040	GP clinical event records	N042100	Rheumatoid lung disease
42040	GP clinical event records	N042200	Rheumatoid nodule
42040	GP clinical event records	N042.00	Other rheumatoid arthropathy + visceral/systemic involvement
42040	GP clinical event records	N042z00	Rheumatoid arthropathy + visceral/systemic involvement NOS
42040	GP clinical event records	N047.00	Seropositive errosive rheumatoid arthritis
42040	GP clinical event records	N04..00	Rheumatoid arthritis and other inflammatory polyarthropathy
42040	GP clinical event records	N04X.00	Seropositive rheumatoid arthritis
42040	GP clinical event records	N04y000	Rheumatoid lung
42040	GP clinical event records	N04y011	Caplan’s syndrome
42040	GP clinical event records	N04y012	Fibrosing alveolitis associated with rheumatoid arthritis
42040	GP clinical event records	N04y200	Adult-onset Still’s disease
42040	GP clinical event records	N005.00	Adult Still’s Disease
42040	GP clinical event records	Nyu1000	[X]Rheumatoid arthritis+involvement/other organs or systems
42040	GP clinical event records	Nyu1100	[X]Other seropositive rheumatoid arthritis
42040	GP clinical event records	Nyu1200	[X]Other specified rheumatoid arthritis
42040	GP clinical event records	Nyu1G00	[X]Seropositive rheumatoid arthritis unspecified
42040	GP clinical event records	XaaWt	Rheumatoid arthritis monitoring invitation first letter
42040	GP clinical event records	X701i	Seronegative rheumatoid arthritis
42040	GP clinical event records	XE1DU	Rheumatoid arthritis and other inflammatory polyarthropathies
42040	GP clinical event records	XaaWw	Rheumatoid arthritis monitoring verbal invitation
42040	GP clinical event records	X701l	Rheumatoid vasculitis
42040	GP clinical event records	Xa3gL	Rheumatoid arthritis - multiple joint
42040	GP clinical event records	XaaWu	Rheumatoid arthritis monitoring invitation second letter
42040	GP clinical event records	XaaWv	Rheumatoid arthritis monitoring invitation third letter
42040	GP clinical event records	XaaWx	Rheumatoid arthritis monitoring telephone invitation
42040	GP clinical event records	N0422	Rheumatoid nodule
42040	GP clinical event records	XaBMO	Seropositive errosive rheumatoid arthritis
42040	GP clinical event records	XaaWW	Rheumatoid arthritis monitoring invitation
42040	GP clinical event records	N0421	Rheumatoid lung
42040	GP clinical event records	XaLsj	Delivery of rehabilitation for rheumatoid arthritis
42040	GP clinical event records	N0421	Rheumatoid lung