| Name |
Rosacea (rosacea) |
| Category |
Skin |
| Sex |
|
| Adult |
Yes |
| UUID |
a0b1c048-4ad7-436b-88a2-4d3fce7264bf |
| Definition |
A chronic skin condition characterized by facial redness, small and superficial dilated blood vessels on facial skin, papules, pustules, and swelling. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
10968 |
| Female (%) |
6669 (61%) |
| Male (%) |
4299 (39%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
313.2 (301.48,324.92) |
| Male |
214.75 (204.12,225.38) |
Incidence stratified by sex
| Female |
21.73 (20.5,22.97) |
| Male |
19.62 (18.34,20.89) |
Incidence stratified by age
| Ages 40-44 |
24.74 (21.61,27.88) |
| Ages 45-49 |
19.88 (17.46,22.29) |
| Ages 50-54 |
21.18 (18.87,23.49) |
| Ages 55-59 |
20.99 (18.91,23.07) |
| Ages 60-64 |
21.04 (19.24,22.83) |
| Ages 65-69 |
18.46 (16.54,20.38) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
337 (319,355) |
396 (381,411) |
415 (402,428) |
| CALIBER |
312 (307,317) |
388 (383,394) |
417 (411,423) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
395(351,443) |
452(416,489) |
432(403,462) |
| Low |
327(287,371) |
394(361,430) |
436(407,466) |
| Medium |
329(290,372) |
421(387,457) |
419(391,450) |
| High |
349(312,389) |
383(351,418) |
408(378,439) |
| Most deprived |
299(267,334) |
329(299,361) |
369(340,400) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
329(310,349) |
397(380,414) |
418(403,433) |
| Scotland |
309(262,361) |
331(295,371) |
337(303,373) |
| Wales |
472(398,556) |
494(437,557) |
505(454,561) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153595, Events=126
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.75 (0.51, 1.1) |
0.143 |
| BMI |
obese |
0.53 (0.31, 0.88) |
0.014 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.05 (0.71, 1.56) |
0.804 |
| smoking |
current |
1.31 (0.76, 2.25) |
0.339 |
| hypertension |
yes |
1.64 (1.09, 2.47) |
0.0186 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1660 |
rosacea |
| 41202 |
Diagnoses - main ICD10 |
L71.1 |
Rhinophyma |
| 41202 |
Diagnoses - main ICD10 |
L71.8 |
Other rosacea |
| 41202 |
Diagnoses - main ICD10 |
L71.9 |
Rosacea, unspecified |
| 41204 |
Diagnoses - secondary ICD10 |
L71.1 |
Rhinophyma |
| 41204 |
Diagnoses - secondary ICD10 |
L71.8 |
Other rosacea |
| 41204 |
Diagnoses - secondary ICD10 |
L71.9 |
Rosacea, unspecified |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L71.1 |
Rhinophyma |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L71.8 |
Other rosacea |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L71.9 |
Rosacea, unspecified |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L71.1 |
Rhinophyma |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L71.8 |
Other rosacea |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L71.9 |
Rosacea, unspecified |
| 42040 |
GP clinical event records |
F4C3100 |
Rosacea conjunctivitis |
| 42040 |
GP clinical event records |
M153000 |
Acne rosacea |
| 42040 |
GP clinical event records |
M153100 |
Rhinophyma |
| 42040 |
GP clinical event records |
M153200 |
Rosacea hypertrophica |
| 42040 |
GP clinical event records |
M153300 |
Lupoid rosacea |
| 42040 |
GP clinical event records |
M153400 |
Ocular rosacea |
| 42040 |
GP clinical event records |
M153.00 |
Rosacea |
| 42040 |
GP clinical event records |
M153z00 |
Rosacea NOS |
| 42040 |
GP clinical event records |
Myu6900 |
[X]Other rosacea |