Sarcoidosis

Metadata

Name	Sarcoidosis (sarcoid)
Category	Haematological or immunological
Sex
Adult	Yes
UUID	b7a42f1b-f78e-44a6-b98c-a0d12bba9a61
Definition	An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.

Ontologies

Disease Ontology (DOID)	DOID_11335
GWAS Catalogue	EFO_0000690
MeSH	D012507
SNOMED-CT	31541009
FinnGen	D3_SARCOIDOSIS

Key Summary Statistics

Cases from any source

Total	2187
Female (%)	1176 (54%)
Male (%)	1011 (46%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	34.89 (30.92,38.86)
Male	38.22 (33.69,42.74)

Incidence stratified by sex

Female	1.13 (0.85,1.4)
Male	0.95 (0.67,1.23)

Incidence stratified by age

Ages 40-44	1.31 (0.6,2.02)
Ages 45-49	1.34 (0.72,1.96)
Ages 50-54	0.95 (0.47,1.43)
Ages 55-59	0.73 (0.35,1.11)
Ages 60-64	1.08 (0.68,1.48)
Ages 65-69	1.06 (0.61,1.51)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	32 (27,38)	35 (30,39)	42 (38,46)
CALIBER	25 (24,27)	36 (35,38)	39 (37,41)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	33(21,49)	33(24,44)	44(35,55)
Low	24(13,39)	33(23,44)	32(25,41)
Medium	24(14,38)	41(31,54)	36(28,45)
High	34(23,49)	31(22,42)	50(40,61)
Most deprived	42(30,56)	37(27,48)	49(39,61)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	31(25,38)	34(29,39)	37(33,41)
Scotland	37(22,58)	36(25,51)	78(62,97)
Wales	36(17,66)	38(23,59)	39(25,56)

Definition

UK Biobank field id	Description	Code	Value
22173	Recent medication for sarcoidosis	1	Yes
22133	Doctor diagnosed sarcoidosis	1	sarcoidosis
20002	Non-cancer illness code, self-reported	1371	sarcoidosis
41202	Diagnoses - main ICD10	D86	Sarcoidosis
41202	Diagnoses - main ICD10	G53.2	Multiple cranial nerve palsies in sarcoidosis
41202	Diagnoses - main ICD10	M63.3	Myositis in sarcoidosis
41204	Diagnoses - secondary ICD10	D86	Sarcoidosis
41204	Diagnoses - secondary ICD10	G53.2	Multiple cranial nerve palsies in sarcoidosis
41204	Diagnoses - secondary ICD10	M63.3	Myositis in sarcoidosis
40001	Underlying (primary) cause of death: ICD10	D86	Sarcoidosis
40001	Underlying (primary) cause of death: ICD10	G53.2	Multiple cranial nerve palsies in sarcoidosis
40001	Underlying (primary) cause of death: ICD10	M63.3	Myositis in sarcoidosis
40002	Contributory (secondary) causes of death: ICD10	D86	Sarcoidosis
40002	Contributory (secondary) causes of death: ICD10	G53.2	Multiple cranial nerve palsies in sarcoidosis
40002	Contributory (secondary) causes of death: ICD10	M63.3	Myositis in sarcoidosis
42040	GP clinical event records	AD50.00	Sarcoidosis of lung
42040	GP clinical event records	AD51.00	Sarcoidosis of lymph nodes
42040	GP clinical event records	AD52.00	Sarcoidosis of lung with sarcoidosis of lymph nodes
42040	GP clinical event records	AD53000	Lupus pernio
42040	GP clinical event records	AD53.00	Sarcoidosis of skin
42040	GP clinical event records	AD54.00	Sarcoidosis of inferior turbinates
42040	GP clinical event records	AD55.00	Sarcoid arthropathy
42040	GP clinical event records	AD5..00	Sarcoidosis
42040	GP clinical event records	Cyu0600	[X]Sarcoidosis of other and combined sites
42040	GP clinical event records	F013.00	Meningitis due to sarcoidosis
42040	GP clinical event records	F326300	Multiple cranial nerve palsies in sarcoidosis
42040	GP clinical event records	F374900	Polyneuropathy in sarcoidosis
42040	GP clinical event records	F396500	Myopathy due to sarcoidosis
42040	GP clinical event records	G558300	Sarcoid heart disease
42040	GP clinical event records	G5y7.00	Sarcoid myocarditis
42040	GP clinical event records	H57y200	Pulmonary sarcoidosis
42040	GP clinical event records	J63A.00	Hepatic granulomas in sarcoidosis
42040	GP clinical event records	N233200	Myositis in sarcoidosis
42040	GP clinical event records	X20GY	Lupus pernio
42040	GP clinical event records	XaCL7	Sarcoidosis of inferior turbinates