| Name |
Scleritis and episcleritis (scleritis) |
| Category |
Eye |
| Sex |
|
| Adult |
Yes |
| UUID |
804d815f-3025-4e8c-9c12-fd273341dcd1 |
| Definition |
Inflammation of the sclera or episclera. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
785 |
| Female (%) |
517 (66%) |
| Male (%) |
268 (34%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
24.64 (21.3,27.97) |
| Male |
15.82 (12.9,18.73) |
Incidence stratified by sex
| Female |
1.2 (0.91,1.48) |
| Male |
0.72 (0.48,0.96) |
Incidence stratified by age
| Ages 40-44 |
1.31 (0.6,2.02) |
| Ages 45-49 |
1.19 (0.61,1.77) |
| Ages 50-54 |
1.27 (0.71,1.82) |
| Ages 55-59 |
0.36 (0.09,0.63) |
| Ages 60-64 |
1.04 (0.65,1.43) |
| Ages 65-69 |
0.96 (0.53,1.39) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
20 (16,25) |
30 (26,34) |
32 (28,36) |
| CALIBER |
56 (54,58) |
75 (72,77) |
79 (76,81) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
23(13,37) |
29(21,40) |
39(31,49) |
| Low |
21(12,35) |
33(24,44) |
27(20,35) |
| Medium |
16(8,27) |
31(22,42) |
28(21,37) |
| High |
24(15,37) |
31(22,42) |
31(23,40) |
| Most deprived |
17(10,27) |
25(17,34) |
34(26,44) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
14(10,18) |
23(19,28) |
25(21,28) |
| Scotland |
29(16,48) |
34(23,49) |
48(36,62) |
| Wales |
76(48,114) |
88(65,117) |
82(62,106) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.96 (0.75, 1.22) |
0.716 |
| BMI |
obese |
1.36 (1.06, 1.76) |
0.0167 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.37 (1.1, 1.7) |
0.00438 |
| smoking |
current |
2.14 (1.6, 2.85) |
2.26e-07 |
| hypertension |
yes |
1.88 (1.53, 2.31) |
1.47e-09 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
H15.0 |
Scleritis |
| 41202 |
Diagnoses - main ICD10 |
H15.1 |
Episcleritis |
| 41202 |
Diagnoses - main ICD10 |
H19.0 |
Scleritis and episcleritis in diseases classified elsewhere |
| 41204 |
Diagnoses - secondary ICD10 |
H15.0 |
Scleritis |
| 41204 |
Diagnoses - secondary ICD10 |
H15.1 |
Episcleritis |
| 41204 |
Diagnoses - secondary ICD10 |
H19.0 |
Scleritis and episcleritis in diseases classified elsewhere |
| 40001 |
Underlying (primary) cause of death: ICD10 |
H15.0 |
Scleritis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
H15.1 |
Episcleritis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
H19.0 |
Scleritis and episcleritis in diseases classified elsewhere |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
H15.0 |
Scleritis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
H15.1 |
Episcleritis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
H19.0 |
Scleritis and episcleritis in diseases classified elsewhere |
| 42040 |
GP clinical event records |
F4K0000 |
Unspecified scleritis |
| 42040 |
GP clinical event records |
F4K0100 |
Episcleritis periodica fugax |
| 42040 |
GP clinical event records |
F4K0200 |
Nodular episcleritis |
| 42040 |
GP clinical event records |
F4K0300 |
Anterior scleritis |
| 42040 |
GP clinical event records |
F4K0400 |
Scleromalacia perforans |
| 42040 |
GP clinical event records |
F4K0500 |
Sclerokeratitis |
| 42040 |
GP clinical event records |
F4K0600 |
Brawny scleritis |
| 42040 |
GP clinical event records |
F4K0700 |
Posterior scleritis |
| 42040 |
GP clinical event records |
F4K0711 |
Sclerotenonitis |
| 42040 |
GP clinical event records |
F4K0.00 |
Scleritis and episcleritis |
| 42040 |
GP clinical event records |
F4K0.11 |
Episcleritis |
| 42040 |
GP clinical event records |
F4K0.12 |
Scleritis |
| 42040 |
GP clinical event records |
F4K0z00 |
Scleritis or episcleritis NOS |
| 42040 |
GP clinical event records |
FyuD800 |
[X]Scleritis+episcleritis in diseases CE |
| 42040 |
GP clinical event records |
XE171 |
Posterior scleritis |
| 42040 |
GP clinical event records |
F4A52 |
Sclerokeratitis |
| 42040 |
GP clinical event records |
XE170 |
Scleritis and episcleritis |