Metadata
| Name | Scoliosis (scoliosis) |
| Category | Musculoskeletal |
| Sex | |
| Adult | Yes |
| UUID | 1bb5dd71-ec8c-4a8b-97d8-b7e712fc3f97 |
| Definition | An appreciable lateral deviation in the normally straight vertical line of the spine. |
Ontologies
| Disease Ontology (DOID) | DOID_0060249 |
| GWAS Catalogue | EFO_0004273 |
| MeSH | D012600 |
| SNOMED-CT | 298382003 |
| FinnGen | M13_SCOLIOSIS |
Key Summary Statistics
Cases from any source
| Total | 4249 |
| Female (%) | 3062 (72%) |
| Male (%) | 1187 (28%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 59.41 (54.24,64.58) |
| Male | 39.06 (34.48,43.63) |
Incidence stratified by sex
| Female | 4.63 (4.07,5.2) |
| Male | 1.88 (1.49,2.27) |
Incidence stratified by age
| Ages 40-44 | 1.31 (0.6,2.03) |
| Ages 45-49 | 1.86 (1.13,2.59) |
| Ages 50-54 | 1.97 (1.28,2.67) |
| Ages 55-59 | 2.82 (2.07,3.57) |
| Ages 60-64 | 4.52 (3.7,5.34) |
| Ages 65-69 | 5.61 (4.56,6.65) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 52 (46,60) | 56 (50,62) | 75 (69,80) |
| CALIBER | 59 (57,61) | 65 (63,67) | 91 (88,94) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 39(26,56) | 43(33,56) | 71(60,84) |
| Low | 53(37,72) | 57(45,71) | 68(57,81) |
| Medium | 58(43,78) | 52(40,65) | 81(69,95) |
| High | 51(38,68) | 60(47,74) | 77(65,91) |
| Most deprived | 58(44,74) | 66(53,81) | 76(64,91) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 52(45,60) | 56(50,63) | 79(73,85) |
| Scotland | 48(31,71) | 56(42,74) | 49(36,64) |
| Wales | 61(37,96) | 52(35,75) | 71(53,93) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153520, Events=195
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.39 (0.98, 1.99) | 0.068 |
| BMI | obese | 1.63 (1.11, 2.4) | 0.0126 |
| BMI | underweight | 0 (0, Inf) | 0.99 |
| smoking | previous | 1.5 (1.1, 2.03) | 0.00988 |
| smoking | current | 1.45 (0.93, 2.27) | 0.0986 |
| hypertension | yes | 1.38 (0.98, 1.93) | 0.0624 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1535 | scoliosis |
| 41202 | Diagnoses - main ICD10 | M41 | Scoliosis |
| 41204 | Diagnoses - secondary ICD10 | M41 | Scoliosis |
| 40001 | Underlying (primary) cause of death: ICD10 | M41 | Scoliosis |
| 40002 | Contributory (secondary) causes of death: ICD10 | M41 | Scoliosis |
| 42040 | GP clinical event records | 2376.00 | O/E - kyphoscoliotic chest def |
| 42040 | GP clinical event records | 7J44111 | Dwyer anterior wiring of spine for scoliosis |
| 42040 | GP clinical event records | G411.00 | Kyphoscoliotic heart disease |
| 42040 | GP clinical event records | N373000 | Idiopathic scoliosis |
| 42040 | GP clinical event records | N373100 | Idiopathic kyphoscoliosis |
| 42040 | GP clinical event records | N373200 | Resolving infantile idiopathic scoliosis |
| 42040 | GP clinical event records | N373300 | Progressive infantile idiopathic scoliosis |
| 42040 | GP clinical event records | N373500 | Thoracogenic scoliosis |
| 42040 | GP clinical event records | N373600 | Postural scoliosis |
| 42040 | GP clinical event records | N373700 | Adolescent idiopathic scoliosis |
| 42040 | GP clinical event records | N373.00 | Kyphoscoliosis and scoliosis |
| 42040 | GP clinical event records | N373z00 | Kyphoscoliosis or scoliosis NOS |
| 42040 | GP clinical event records | N374300 | Scoliosis associated with other condition |
| 42040 | GP clinical event records | N374A00 | Scoliosis in skeletal dysplasia |
| 42040 | GP clinical event records | N374B00 | Neuromuscular scoliosis |
| 42040 | GP clinical event records | N374C00 | Scoliosis in neurofibromatosis |
| 42040 | GP clinical event records | N374D00 | Scoliosis in connective tissue anomalies |
| 42040 | GP clinical event records | Nyu5300 | [X]Other idiopathic scoliosis |
| 42040 | GP clinical event records | Nyu5400 | [X]Other secondary scoliosis |
| 42040 | GP clinical event records | Nyu5500 | [X]Other forms of scoliosis |
| 42040 | GP clinical event records | PE22.00 | Congenital postural scoliosis |
| 42040 | GP clinical event records | PE23.00 | Congenital scoliosis due to congenital bony malformation |
| 42040 | GP clinical event records | PG18.11 | Congenital kyphoscoliosis |
| 42040 | GP clinical event records | XE1M4 | Congenital kyphosis |
| 42040 | GP clinical event records | XE0Ir | Correction of spinal deformity and anterior instrumentation |