| Name |
Secondary Malignancy of Adrenal gland (sec_adrenal) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
966597e2-cf8e-429e-aea1-e156f489d05e |
| Definition |
Cancer which has spread from a primary site of origin to the adrenal gland. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
923 |
| Female (%) |
410 (44%) |
| Male (%) |
513 (56%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
0.12 (-0.11,0.35) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by sex
| Female |
0.67 (0.46,0.88) |
| Male |
1.45 (1.11,1.79) |
Incidence stratified by age
| Ages 40-44 |
0.2 (-0.08,0.48) |
| Ages 45-49 |
0.22 (-0.03,0.47) |
| Ages 50-54 |
0.57 (0.2,0.94) |
| Ages 55-59 |
1.04 (0.58,1.49) |
| Ages 60-64 |
1.46 (0.99,1.92) |
| Ages 65-69 |
1.76 (1.17,2.34) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
1 (0,2) |
4 (2,6) |
8 (7,11) |
| CALIBER |
– |
6 (5,7) |
13 (12,14) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
0(NaN,NaN) |
7(3,13) |
6(3,11) |
| Low |
2(0,9) |
4(1,10) |
7(4,12) |
| Medium |
0(NaN,NaN) |
2(0,6) |
7(4,12) |
| High |
1(0,6) |
2(0,5) |
10(6,16) |
| Most deprived |
1(0,6) |
6(2,11) |
12(7,19) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
1(0,3) |
5(3,7) |
9(7,11) |
| Scotland |
0(NaN,NaN) |
0(NaN,NaN) |
7(3,15) |
| Wales |
0(NaN,NaN) |
4(0,14) |
7(2,17) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154071, Events=107
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.86 (0.53, 1.38) |
0.527 |
| BMI |
obese |
1.3 (0.79, 2.12) |
0.302 |
| BMI |
underweight |
0 (0, Inf) |
0.993 |
| smoking |
previous |
1.71 (1.07, 2.71) |
0.0234 |
| smoking |
current |
5.39 (3.29, 8.84) |
2.31e-11 |
| hypertension |
yes |
1.43 (0.96, 2.14) |
0.0801 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
C79.7 |
Secondary malignant neoplasm of adrenal gland |
| 41204 |
Diagnoses - secondary ICD10 |
C79.7 |
Secondary malignant neoplasm of adrenal gland |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C79.7 |
Secondary malignant neoplasm of adrenal gland |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C79.7 |
Secondary malignant neoplasm of adrenal gland |
| 42040 |
GP clinical event records |
B587.00 |
Secondary malignant neoplasm of adrenal gland |
| 40006 |
Type of cancer: ICD10 |
C79.7 |
Secondary malignant neoplasm of adrenal gland |