| Name |
Secondary Malignancy of Bone (sec_bone) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
951381c7-7907-4587-ace7-b1ce37ddd6e4 |
| Definition |
Secondary Malignancy_Bone |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
5964 |
| Female (%) |
2672 (45%) |
| Male (%) |
3292 (55%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
5.3 (3.76,6.85) |
| Male |
4.76 (3.16,6.36) |
Incidence stratified by sex
| Female |
6.03 (5.39,6.67) |
| Male |
8.7 (7.86,9.53) |
Incidence stratified by age
| Ages 40-44 |
1.71 (0.9,2.52) |
| Ages 45-49 |
2.45 (1.61,3.28) |
| Ages 50-54 |
3.99 (3.0,4.97) |
| Ages 55-59 |
6.24 (5.12,7.36) |
| Ages 60-64 |
10.03 (8.81,11.24) |
| Ages 65-69 |
13.17 (11.57,14.76) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
14 (11,18) |
33 (29,38) |
66 (60,71) |
| CALIBER |
13 (12,14) |
33 (31,35) |
77 (74,80) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
10(4,20) |
36(27,48) |
61(50,73) |
| Low |
9(4,20) |
29(21,40) |
54(44,65) |
| Medium |
14(7,25) |
30(21,41) |
60(50,73) |
| High |
22(13,33) |
34(25,46) |
76(63,90) |
| Most deprived |
11(6,20) |
35(25,46) |
80(67,96) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
14(10,19) |
35(30,40) |
66(61,73) |
| Scotland |
9(3,20) |
21(12,32) |
56(42,72) |
| Wales |
19(7,41) |
37(22,57) |
71(53,94) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153994, Events=756
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.05 (0.88, 1.25) |
0.587 |
| BMI |
obese |
1.28 (1.06, 1.55) |
0.0117 |
| BMI |
underweight |
0 (0, Inf) |
0.98 |
| smoking |
previous |
1.34 (1.15, 1.57) |
0.000256 |
| smoking |
current |
2.1 (1.7, 2.6) |
8.79e-12 |
| hypertension |
yes |
1.02 (0.87, 1.19) |
0.824 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20001 |
Cancer code, self-reported |
1085 |
bone metastases / bony secondaries |
| 41202 |
Diagnoses - main ICD10 |
C79.5 |
Secondary malignant neoplasm of bone and bone marrow |
| 41204 |
Diagnoses - secondary ICD10 |
C79.5 |
Secondary malignant neoplasm of bone and bone marrow |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C79.5 |
Secondary malignant neoplasm of bone and bone marrow |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C79.5 |
Secondary malignant neoplasm of bone and bone marrow |
| 42040 |
GP clinical event records |
B585000 |
Pathological fracture due to metastatic bone disease |
| 42040 |
GP clinical event records |
B585.00 |
Secondary malignant neoplasm of bone and bone marrow |
| 42040 |
GP clinical event records |
XaIJA |
Pathological fracture due to metastatic bone disease |
| 40006 |
Type of cancer: ICD10 |
C79.5 |
Secondary malignant neoplasm of bone and bone marrow |