Secondary Malignancy of Bowel

Metadata

Name	Secondary Malignancy of Bowel (sec_bowel)
Category	Cancers
Sex
Adult	Yes
UUID	1da6588a-18ff-446e-85f3-33bfec78122b
Definition	Cancer metastatic to small intestine

Ontologies

MeSH	D009362
SNOMED-CT	94580002
FinnGen	C3_SECONDARY_RESPIRATORY_DIGESTIVE

Key Summary Statistics

Cases from any source

Total	598
Female (%)	368 (62%)
Male (%)	230 (38%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	0.94 (0.29,1.6)
Male	0.56 (0.01,1.11)

Incidence stratified by sex

Female	0.77 (0.54,1.0)
Male	0.46 (0.27,0.66)

Incidence stratified by age

Ages 40-44	0.3 (-0.04,0.64)
Ages 45-49	0.44 (0.09,0.8)
Ages 50-54	0.38 (0.08,0.68)
Ages 55-59	0.52 (0.2,0.84)
Ages 60-64	0.65 (0.34,0.96)
Ages 65-69	1.2 (0.72,1.69)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	2 (1,4)	4 (2,5)	6 (5,8)
CALIBER	–	3 (3,4)	8 (7,9)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	0(NaN,NaN)	4(1,9)	7(4,12)
Low	2(0,9)	4(1,8)	7(4,11)
Medium	1(0,6)	5(2,10)	6(3,11)
High	4(1,11)	3(1,8)	3(1,7)
Most deprived	2(0,7)	2(0,6)	7(3,12)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	2(1,4)	4(2,6)	6(4,8)
Scotland	0(NaN,NaN)	4(1,11)	4(1,10)
Wales	3(0,17)	2(0,9)	12(5,23)

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	C78.4	Secondary malignant neoplasm of small intestine
41202	Diagnoses - main ICD10	C78.5	Secondary malignant neoplasm of large intestine and rectum
41204	Diagnoses - secondary ICD10	C78.4	Secondary malignant neoplasm of small intestine
41204	Diagnoses - secondary ICD10	C78.5	Secondary malignant neoplasm of large intestine and rectum
40001	Underlying (primary) cause of death: ICD10	C78.4	Secondary malignant neoplasm of small intestine
40001	Underlying (primary) cause of death: ICD10	C78.5	Secondary malignant neoplasm of large intestine and rectum
40002	Contributory (secondary) causes of death: ICD10	C78.4	Secondary malignant neoplasm of small intestine
40002	Contributory (secondary) causes of death: ICD10	C78.5	Secondary malignant neoplasm of large intestine and rectum
42040	GP clinical event records	B574000	Secondary malignant neoplasm of duodenum
42040	GP clinical event records	B574100	Secondary malignant neoplasm of jejunum
42040	GP clinical event records	B574200	Secondary malignant neoplasm of ileum
42040	GP clinical event records	B574.00	Secondary malignant neoplasm of small intestine and duodenum
42040	GP clinical event records	B574z00	Secondary malig neop of small intestine or duodenum NOS
42040	GP clinical event records	B575000	Secondary malignant neoplasm of colon
42040	GP clinical event records	B575100	Secondary malignant neoplasm of rectum
42040	GP clinical event records	B575.00	Secondary malignant neoplasm of large intestine and rectum
42040	GP clinical event records	B575z00	Secondary malig neop of large intestine or rectum NOS
42040	GP clinical event records	XaXQk	Secondary malignant neoplasm of large intestine and rectum
40006	Type of cancer: ICD10	C78.4	Secondary malignant neoplasm of small intestine
40006	Type of cancer: ICD10	C78.5	Secondary malignant neoplasm of large intestine and rectum