| Name |
Secondary Malignancy of Brain, Other CNS and Intracranial (sec_brain) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
d7d6ed45-0293-4240-bd9d-ec9a5f802f88 |
| Definition |
Cancer which has spread from a primary site of origin to the brain, cranium, or other site in the central nervous system. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
2155 |
| Female (%) |
1185 (55%) |
| Male (%) |
970 (45%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
1.06 (0.37,1.75) |
| Male |
0.84 (0.17,1.51) |
Incidence stratified by sex
| Female |
3.13 (2.67,3.59) |
| Male |
2.97 (2.48,3.46) |
Incidence stratified by age
| Ages 40-44 |
1.0 (0.38,1.63) |
| Ages 45-49 |
1.19 (0.6,1.77) |
| Ages 50-54 |
2.66 (1.85,3.46) |
| Ages 55-59 |
2.75 (2.01,3.49) |
| Ages 60-64 |
4.26 (3.47,5.05) |
| Ages 65-69 |
4.37 (3.45,5.28) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
6 (4,9) |
13 (10,16) |
24 (21,27) |
| CALIBER |
7 (6,7) |
15 (14,16) |
29 (27,31) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
3(0,9) |
12(7,19) |
22(16,30) |
| Low |
9(4,20) |
11(6,19) |
16(11,22) |
| Medium |
6(2,14) |
9(5,16) |
23(17,31) |
| High |
10(5,19) |
14(9,22) |
22(16,30) |
| Most deprived |
2(0,7) |
18(12,27) |
37(28,47) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
6(4,10) |
13(10,16) |
24(20,27) |
| Scotland |
2(0,13) |
13(6,23) |
21(13,31) |
| Wales |
6(1,22) |
11(4,25) |
27(16,43) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154057, Events=319
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.95 (0.73, 1.23) |
0.691 |
| BMI |
obese |
1.11 (0.83, 1.49) |
0.465 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.56 (1.21, 2) |
0.00057 |
| smoking |
current |
3.52 (2.62, 4.73) |
7.31e-17 |
| hypertension |
yes |
1.28 (1, 1.63) |
0.0477 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
C79.3 |
Secondary malignant neoplasm of brain and cerebral meninges |
| 41202 |
Diagnoses - main ICD10 |
C79.4 |
Secondary malignant neoplasm of other and unspecified parts of nervous system |
| 41204 |
Diagnoses - secondary ICD10 |
C79.3 |
Secondary malignant neoplasm of brain and cerebral meninges |
| 41204 |
Diagnoses - secondary ICD10 |
C79.4 |
Secondary malignant neoplasm of other and unspecified parts of nervous system |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C79.3 |
Secondary malignant neoplasm of brain and cerebral meninges |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C79.4 |
Secondary malignant neoplasm of other and unspecified parts of nervous system |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C79.3 |
Secondary malignant neoplasm of brain and cerebral meninges |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C79.4 |
Secondary malignant neoplasm of other and unspecified parts of nervous system |
| 42040 |
GP clinical event records |
B583000 |
Secondary malignant neoplasm of brain |
| 42040 |
GP clinical event records |
B583100 |
Secondary malignant neoplasm of spinal cord |
| 42040 |
GP clinical event records |
B583200 |
Cerebral metastasis |
| 42040 |
GP clinical event records |
B583.00 |
Secondary malignant neoplasm of brain and spinal cord |
| 42040 |
GP clinical event records |
B583z00 |
Secondary malignant neoplasm of brain or spinal cord NOS |
| 42040 |
GP clinical event records |
XM1Pr |
Cerebral metastasis |
| 40006 |
Type of cancer: ICD10 |
C79.3 |
Secondary malignant neoplasm of brain and cerebral meninges |
| 40006 |
Type of cancer: ICD10 |
C79.4 |
Secondary malignant neoplasm of other and unspecified parts of nervous system |