| Name |
Secondary malignancy of Liver and intrahepatic bile duct (sec_liver) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
c0116605-9063-4526-8a35-e1027171a2b1 |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
7124 |
| Female (%) |
3653 (51%) |
| Male (%) |
3471 (49%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
5.89 (4.26,7.53) |
| Male |
6.58 (4.7,8.46) |
Incidence stratified by sex
| Female |
7.47 (6.76,8.18) |
| Male |
9.27 (8.4,10.13) |
Incidence stratified by age
| Ages 40-44 |
2.01 (1.13,2.89) |
| Ages 45-49 |
3.63 (2.62,4.65) |
| Ages 50-54 |
5.57 (4.41,6.74) |
| Ages 55-59 |
7.43 (6.22,8.65) |
| Ages 60-64 |
11.18 (9.9,12.47) |
| Ages 65-69 |
13.77 (12.14,15.4) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
17 (13,21) |
39 (35,44) |
71 (66,77) |
| CALIBER |
16 (15,17) |
42 (41,44) |
92 (88,95) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
12(6,24) |
38(28,51) |
74(62,87) |
| Low |
16(8,29) |
34(25,46) |
56(46,67) |
| Medium |
11(5,22) |
42(32,55) |
65(54,77) |
| High |
25(16,37) |
32(23,44) |
78(65,92) |
| Most deprived |
16(9,26) |
49(38,62) |
88(74,103) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
17(13,22) |
39(34,45) |
72(66,79) |
| Scotland |
10(3,23) |
34(23,48) |
58(45,75) |
| Wales |
21(8,45) |
48(31,71) |
78(58,101) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154057, Events=319
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.95 (0.73, 1.23) |
0.691 |
| BMI |
obese |
1.11 (0.83, 1.49) |
0.465 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.56 (1.21, 2) |
0.00057 |
| smoking |
current |
3.52 (2.62, 4.73) |
7.31e-17 |
| hypertension |
yes |
1.28 (1, 1.63) |
0.0477 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
C78.7 |
Secondary malignant neoplasm of liver and intrahepatic bile duct |
| 41204 |
Diagnoses - secondary ICD10 |
C78.7 |
Secondary malignant neoplasm of liver and intrahepatic bile duct |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C78.7 |
Secondary malignant neoplasm of liver and intrahepatic bile duct |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C78.7 |
Secondary malignant neoplasm of liver and intrahepatic bile duct |
| 42040 |
GP clinical event records |
B153.00 |
Secondary malignant neoplasm of liver |
| 42040 |
GP clinical event records |
B577.00 |
Secondary malignant neoplasm of liver |
| 42040 |
GP clinical event records |
B577.11 |
Liver metastases |
| 40006 |
Type of cancer: ICD10 |
C78.7 |
Secondary malignant neoplasm of liver and intrahepatic bile duct |