Secondary Malignancy of Lymph Nodes

Metadata

Name	Secondary Malignancy of Lymph Nodes (sec_LN)
Category	Cancers
Sex
Adult	Yes
UUID	836574f4-f369-4c8e-8e0c-8436296b3dba
Definition	Cancer which has spread from a primary site of origin to the lymph nodes.

Ontologies

SNOMED-CT	94392001
FinnGen	C3_LYMPHNODES_SECONDARY_NAS

Key Summary Statistics

Cases from any source

Total	12046
Female (%)	7312 (61%)
Male (%)	4734 (39%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	61.65 (56.38,66.92)
Male	22.68 (19.19,26.17)

Incidence stratified by sex

Female	16.03 (14.98,17.07)
Male	12.75 (11.74,13.77)

Incidence stratified by age

Ages 40-44	6.05 (4.52,7.58)
Ages 45-49	9.24 (7.61,10.86)
Ages 50-54	10.51 (8.9,12.11)
Ages 55-59	14.08 (12.4,15.76)
Ages 60-64	18.41 (16.76,20.07)
Ages 65-69	20.96 (18.94,22.98)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	60 (53,68)	109 (101,117)	159 (151,168)
CALIBER	46 (44,48)	96 (93,99)	158 (154,162)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	60(44,81)	108(92,127)	160(143,179)
Low	64(47,85)	99(83,117)	155(138,173)
Medium	62(46,81)	114(96,133)	140(124,158)
High	68(52,86)	113(96,132)	174(155,195)
Most deprived	50(37,65)	110(94,129)	170(150,191)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	62(54,71)	108(99,117)	159(150,168)
Scotland	55(37,78)	106(86,130)	147(126,172)
Wales	49(28,80)	122(94,155)	184(153,218)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153944, Events=165

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.93 (0.64, 1.33)	0.683
BMI	obese	0.99 (0.66, 1.49)	0.954
BMI	underweight	0 (0, Inf)	0.994
smoking	previous	1.57 (1.13, 2.18)	0.00649
smoking	current	1.16 (0.66, 2.02)	0.611
hypertension	yes	0.69 (0.47, 1.01)	0.0533

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	C77	Secondary and unspecified malignant neoplasm of lymph nodes
41204	Diagnoses - secondary ICD10	C77	Secondary and unspecified malignant neoplasm of lymph nodes
40001	Underlying (primary) cause of death: ICD10	C77	Secondary and unspecified malignant neoplasm of lymph nodes
40002	Contributory (secondary) causes of death: ICD10	C77	Secondary and unspecified malignant neoplasm of lymph nodes
42040	GP clinical event records	B560000	Secondary and unspec malig neop of superficial parotid LN
42040	GP clinical event records	B560100	Secondary and unspec malignant neoplasm mastoid lymph nodes
42040	GP clinical event records	B560200	Secondary and unspec malig neop superficial cervical LN
42040	GP clinical event records	B560300	Secondary and unspec malignant neoplasm occipital lymph node
42040	GP clinical event records	B560400	Secondary and unspec malig neop deep parotid lymph nodes
42040	GP clinical event records	B560500	Secondary and unspec malig neop submandibular lymph nodes
42040	GP clinical event records	B560600	Secondary and unspec malig neop of facial lymph nodes
42040	GP clinical event records	B560700	Secondary and unspec malig neop submental lymph nodes
42040	GP clinical event records	B560800	Secondary and unspec malig neop anterior cervical LN
42040	GP clinical event records	B560900	Secondary and unspec malig neop deep cervical LN
42040	GP clinical event records	B560.00	Secondary and unspec malig neop lymph nodes head/face/neck
42040	GP clinical event records	B560z00	Secondary unspec malig neop lymph nodes head/face/neck NOS
42040	GP clinical event records	B561000	Secondary and unspec malig neop internal mammary lymph nodes
42040	GP clinical event records	B561100	Secondary and unspec malig neop intercostal lymph nodes
42040	GP clinical event records	B561200	Secondary and unspec malig neop diaphragmatic lymph nodes
42040	GP clinical event records	B561300	Secondary and unspec malig neop ant mediastinal lymph nodes
42040	GP clinical event records	B561400	Secondary and unspec malig neop post mediastinal lymph nodes
42040	GP clinical event records	B561500	Secondary and unspec malig neop paratracheal lymph nodes
42040	GP clinical event records	B561600	Secondary and unspec malig neop superfic tracheobronchial LN
42040	GP clinical event records	B561700	Secondary and unspec malig neop inferior tracheobronchial LN
42040	GP clinical event records	B561800	Secondary and unspec malig neop bronchopulmonary lymph nodes
42040	GP clinical event records	B561900	Secondary and unspec malig neop pulmonary lymph nodes
42040	GP clinical event records	B561.00	Secondary and unspec malig neop intrathoracic lymph nodes
42040	GP clinical event records	B561z00	Secondary and unspec malig neop intrathoracic LN NOS
42040	GP clinical event records	B562000	Secondary and unspec malig neop coeliac lymph nodes
42040	GP clinical event records	B562100	Secondary and unspec malig neop superficial mesenteric LN
42040	GP clinical event records	B562200	Secondary and unspec malig neop inferior mesenteric LN
42040	GP clinical event records	B562300	Secondary and unspec malig neop common iliac lymph nodes
42040	GP clinical event records	B562400	Secondary and unspec malig neop external iliac lymph nodes
42040	GP clinical event records	B562.00	Secondary and unspec malig neop intra-abdominal lymph nodes
42040	GP clinical event records	B562z00	Secondary and unspec malig neop intra-abdominal LN NOS
42040	GP clinical event records	B563000	Secondary and unspec malig neop axillary lymph nodes
42040	GP clinical event records	B563100	Secondary and unspec malig neop supratrochlear lymph nodes
42040	GP clinical event records	B563200	Secondary and unspec malig neop infraclavicular lymph nodes
42040	GP clinical event records	B563300	Secondary and unspec malig neop pectoral lymph nodes
42040	GP clinical event records	B563.00	Secondary and unspec malig neop axilla and upper limb LN
42040	GP clinical event records	B563z00	Secondary and unspec malig neop axilla and upper limb LN NOS
42040	GP clinical event records	B564000	Secondary and unspec malig neop superficial inguinal LN
42040	GP clinical event records	B564100	Secondary and unspec malig neop deep inguinal lymph nodes
42040	GP clinical event records	B564.00	Secondary and unspec malig neop inguinal and lower limb LN
42040	GP clinical event records	B564z00	Secondary and unspec malig neop of inguinal and leg LN NOS
42040	GP clinical event records	B565000	Secondary and unspec malig neop internal iliac lymph nodes
42040	GP clinical event records	B565200	Secondary and unspec malig neop circumflex iliac LN
42040	GP clinical event records	B565300	Secondary and unspec malig neop sacral lymph nodes
42040	GP clinical event records	B565.00	Secondary and unspec malig neop intrapelvic lymph nodes
42040	GP clinical event records	B565z00	Secondary and unspec malig neop intrapelvic LN NOS
42040	GP clinical event records	B56..00	Secondary and unspecified malignant neoplasm of lymph nodes
42040	GP clinical event records	B56..11	Lymph node metastases
42040	GP clinical event records	B56y.00	Secondary and unspec malig neop lymph nodes multiple sites
42040	GP clinical event records	B56z.00	Secondary and unspec malig neop lymph nodes NOS
42040	GP clinical event records	ByuC200	[X]2ndry+unspcf malignant neoplasm lymph nodes/multi regions
42040	GP clinical event records	XE2xB	Secondary and unspecified malignant neoplasm of lymph nodes
40006	Type of cancer: ICD10	C77	Secondary and unspecified malignant neoplasm of lymph nodes