| Name |
Secondary Malignancy of Lung (sec_lung) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
c842a748-9343-4181-a724-09237ef551a9 |
| Definition |
Secondary Malignancy_Lung |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
5175 |
| Female (%) |
2601 (50%) |
| Male (%) |
2574 (50%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
3.54 (2.27,4.8) |
| Male |
5.6 (3.86,7.33) |
Incidence stratified by sex
| Female |
5.8 (5.17,6.43) |
| Male |
7.43 (6.66,8.21) |
Incidence stratified by age
| Ages 40-44 |
1.31 (0.6,2.02) |
| Ages 45-49 |
3.26 (2.3,4.23) |
| Ages 50-54 |
4.62 (3.56,5.68) |
| Ages 55-59 |
5.61 (4.56,6.67) |
| Ages 60-64 |
9.34 (8.16,10.51) |
| Ages 65-69 |
10.15 (8.75,11.55) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
12 (9,16) |
29 (25,33) |
57 (52,62) |
| CALIBER |
12 (11,13) |
29 (27,30) |
62 (60,65) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
8(3,18) |
28(19,38) |
56(46,68) |
| Low |
20(11,34) |
29(20,40) |
55(45,67) |
| Medium |
11(5,21) |
26(18,36) |
55(45,67) |
| High |
14(8,24) |
27(19,37) |
55(45,68) |
| Most deprived |
9(5,17) |
34(25,46) |
63(51,76) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
12(8,16) |
28(24,33) |
58(53,64) |
| Scotland |
8(2,21) |
30(20,44) |
55(42,71) |
| Wales |
26(11,50) |
32(18,51) |
46(32,65) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154057, Events=319
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.95 (0.73, 1.23) |
0.691 |
| BMI |
obese |
1.11 (0.83, 1.49) |
0.465 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.56 (1.21, 2) |
0.00057 |
| smoking |
current |
3.52 (2.62, 4.73) |
7.31e-17 |
| hypertension |
yes |
1.28 (1, 1.63) |
0.0477 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
C78.0 |
Secondary malignant neoplasm of lung |
| 41204 |
Diagnoses - secondary ICD10 |
C78.0 |
Secondary malignant neoplasm of lung |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C78.0 |
Secondary malignant neoplasm of lung |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C78.0 |
Secondary malignant neoplasm of lung |
| 42040 |
GP clinical event records |
B570.00 |
Secondary malignant neoplasm of lung |
| 40006 |
Type of cancer: ICD10 |
C78.0 |
Secondary malignant neoplasm of lung |