Metadata
| Name | Secondary or other Thrombocytopaenia (sec_oth_thrombocytopaenia) |
| Category | Haematological or immunological |
| Sex | |
| Adult | Yes |
| UUID | bbfc7cfe-e235-4da7-94b3-b0dfcc70cde7 |
| Definition | Excess platelets in the bloodstream that develops as a result of another disorder and rarely leads to excessive blood clotting or bleeding |
Ontologies
| Disease Ontology (DOID) | DOID_11126 |
| SNOMED-CT | 154826009 |
| FinnGen | D3_SCNDTHROMBOCYTOPENIA |
Key Summary Statistics
Cases from any source
| Total | 4315 |
| Female (%) | 1855 (43%) |
| Male (%) | 2460 (57%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 25.7 (22.29,29.1) |
| Male | 26.88 (23.08,30.68) |
Incidence stratified by sex
| Female | 3.96 (3.45,4.48) |
| Male | 6.44 (5.72,7.16) |
Incidence stratified by age
| Ages 40-44 | 2.12 (1.21,3.02) |
| Ages 45-49 | 3.05 (2.11,3.98) |
| Ages 50-54 | 3.49 (2.57,4.41) |
| Ages 55-59 | 5.11 (4.1,6.12) |
| Ages 60-64 | 6.24 (5.28,7.21) |
| Ages 65-69 | 7.72 (6.49,8.94) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 35 (29,41) | 49 (44,55) | 70 (65,76) |
| CALIBER | 31 (30,33) | 44 (42,46) | 67 (64,70) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 21(12,35) | 37(27,48) | 65(54,78) |
| Low | 34(22,50) | 53(41,68) | 72(60,85) |
| Medium | 31(20,46) | 39(29,51) | 62(51,74) |
| High | 37(26,52) | 55(43,69) | 73(60,87) |
| Most deprived | 44(32,59) | 62(50,77) | 80(67,96) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 34(28,41) | 51(45,57) | 70(64,77) |
| Scotland | 37(22,58) | 53(39,71) | 65(51,83) |
| Wales | 40(21,68) | 29(16,48) | 72(53,95) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153321, Events=259
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.47 (1.07, 2.01) | 0.0165 |
| BMI | obese | 2.46 (1.81, 3.35) | 1.19e-08 |
| BMI | underweight | 0 (0, Inf) | 0.998 |
| smoking | previous | 1.06 (0.81, 1.39) | 0.676 |
| smoking | current | 0.75 (0.46, 1.22) | 0.25 |
| hypertension | yes | 0.83 (0.58, 1.19) | 0.31 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 41202 | Diagnoses - main ICD10 | D69.5 | Secondary thrombocytopenia |
| 41202 | Diagnoses - main ICD10 | D69.6 | Thrombocytopenia, unspecified |
| 41202 | Diagnoses - main ICD10 | D82.0 | Wiskott-Aldrich syndrome |
| 41202 | Diagnoses - main ICD10 | M31.1 | Thrombotic microangiopathy |
| 41204 | Diagnoses - secondary ICD10 | D69.5 | Secondary thrombocytopenia |
| 41204 | Diagnoses - secondary ICD10 | D69.6 | Thrombocytopenia, unspecified |
| 41204 | Diagnoses - secondary ICD10 | D82.0 | Wiskott-Aldrich syndrome |
| 41204 | Diagnoses - secondary ICD10 | M31.1 | Thrombotic microangiopathy |
| 40001 | Underlying (primary) cause of death: ICD10 | D69.5 | Secondary thrombocytopenia |
| 40001 | Underlying (primary) cause of death: ICD10 | D69.6 | Thrombocytopenia, unspecified |
| 40001 | Underlying (primary) cause of death: ICD10 | D82.0 | Wiskott-Aldrich syndrome |
| 40001 | Underlying (primary) cause of death: ICD10 | M31.1 | Thrombotic microangiopathy |
| 40002 | Contributory (secondary) causes of death: ICD10 | D69.5 | Secondary thrombocytopenia |
| 40002 | Contributory (secondary) causes of death: ICD10 | D69.6 | Thrombocytopenia, unspecified |
| 40002 | Contributory (secondary) causes of death: ICD10 | D82.0 | Wiskott-Aldrich syndrome |
| 40002 | Contributory (secondary) causes of death: ICD10 | M31.1 | Thrombotic microangiopathy |
| 42040 | GP clinical event records | 42P2.00 | Thrombocytopenia |
| 42040 | GP clinical event records | 42P8.00 | Heparin induced thrombocytopenia screening test |
| 42040 | GP clinical event records | C391200 | Wiskott - Aldrich syndrome |
| 42040 | GP clinical event records | C391211 | Thrombocytopenic eczema with immunodeficiency |
| 42040 | GP clinical event records | D314100 | Thrombocytopenia due to drugs |
| 42040 | GP clinical event records | D314200 | Thrombocytopenia due to extracorporeal circulation of blood |
| 42040 | GP clinical event records | D314300 | Heparin-induced thrombocytopenia |
| 42040 | GP clinical event records | D314.00 | Secondary thrombocytopenia |
| 42040 | GP clinical event records | D314y00 | Other specified secondary thrombocytopenia |
| 42040 | GP clinical event records | D314z00 | Secondary thrombocytopenia NOS |
| 42040 | GP clinical event records | D315.00 | Thrombocytopenia NOS |
| 42040 | GP clinical event records | G756100 | Thrombotic thrombocytopenic purpura |
| 42040 | GP clinical event records | XE149 | Secondary thrombocytopenia NOS |
| 42040 | GP clinical event records | Xa36j | Heparin-induced thrombocytopenia |
| 42040 | GP clinical event records | G756. | Thrombotic thrombocytopenic purpura |
| 42040 | GP clinical event records | XaJJu | Heparin induced thrombocytopenia screening test |
| 42040 | GP clinical event records | XE24o | Thrombocytopenia |