Metadata
| Name | Secondary Malignancy of Other organs (sec_other) |
| Category | Cancers |
| Sex | |
| Adult | Yes |
| UUID | 21ff5cc6-e967-4391-8f37-d00e292d342d |
| Definition | Secondary malignancy of other specified and nonspecified organs and sites |
Cases from any source
| Total | 5653 |
| Female (%) | 3061 (54%) |
| Male (%) | 2592 (46%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 12.38 (10.01,14.74) |
| Male | 9.38 (7.13,11.62) |
Incidence stratified by sex
| Female | 6.97 (6.28,7.65) |
| Male | 6.42 (5.7,7.14) |
Incidence stratified by age
| Ages 40-44 | 1.31 (0.6,2.02) |
| Ages 45-49 | 3.19 (2.24,4.15) |
| Ages 50-54 | 4.88 (3.79,5.97) |
| Ages 55-59 | 6.45 (5.32,7.59) |
| Ages 60-64 | 8.34 (7.23,9.45) |
| Ages 65-69 | 11.41 (9.93,12.9) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 18 (15,23) | 36 (31,41) | 63 (58,69) |
| CALIBER | 8 (7,8) | 18 (16,19) | 37 (35,38) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 20(11,33) | 35(25,46) | 65(54,78) |
| Low | 17(9,29) | 33(24,44) | 57(47,69) |
| Medium | 19(10,31) | 40(30,52) | 58(48,70) |
| High | 22(14,34) | 30(22,41) | 62(51,75) |
| Most deprived | 14(8,23) | 40(30,53) | 76(63,90) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 18(14,23) | 35(30,40) | 60(54,66) |
| Scotland | 19(9,35) | 42(30,57) | 77(62,96) |
| Wales | 22(9,45) | 37(23,58) | 78(58,101) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154057, Events=319
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.95 (0.73, 1.23) | 0.691 |
| BMI | obese | 1.11 (0.83, 1.49) | 0.465 |
| BMI | underweight | 0 (0, Inf) | 0.992 |
| smoking | previous | 1.56 (1.21, 2) | 0.00057 |
| smoking | current | 3.52 (2.62, 4.73) | 7.31e-17 |
| hypertension | yes | 1.28 (1, 1.63) | 0.0477 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 41202 | Diagnoses - main ICD10 | C78.1 | Secondary malignant neoplasm of mediastinum |
| 41202 | Diagnoses - main ICD10 | C78.3 | Secondary malignant neoplasm of other and unspecified respiratory organs |
| 41202 | Diagnoses - main ICD10 | C78.8 | Secondary malignant neoplasm of other and unspecified digestive organs |
| 41202 | Diagnoses - main ICD10 | C79.0 | Secondary malignant neoplasm of kidney and renal pelvis |
| 41202 | Diagnoses - main ICD10 | C79.1 | Secondary malignant neoplasm of bladder and other and unspecified urinary organs |
| 41202 | Diagnoses - main ICD10 | C79.2 | Secondary malignant neoplasm of skin |
| 41202 | Diagnoses - main ICD10 | C79.6 | Secondary malignant neoplasm of ovary |
| 41202 | Diagnoses - main ICD10 | C79.8 | Secondary malignant neoplasm of other specified sites |
| 41202 | Diagnoses - main ICD10 | C79.9 | Secondary malignant neoplasm, unspecified site |
| 41204 | Diagnoses - secondary ICD10 | C78.1 | Secondary malignant neoplasm of mediastinum |
| 41204 | Diagnoses - secondary ICD10 | C78.3 | Secondary malignant neoplasm of other and unspecified respiratory organs |
| 41204 | Diagnoses - secondary ICD10 | C78.8 | Secondary malignant neoplasm of other and unspecified digestive organs |
| 41204 | Diagnoses - secondary ICD10 | C79.0 | Secondary malignant neoplasm of kidney and renal pelvis |
| 41204 | Diagnoses - secondary ICD10 | C79.1 | Secondary malignant neoplasm of bladder and other and unspecified urinary organs |
| 41204 | Diagnoses - secondary ICD10 | C79.2 | Secondary malignant neoplasm of skin |
| 41204 | Diagnoses - secondary ICD10 | C79.6 | Secondary malignant neoplasm of ovary |
| 41204 | Diagnoses - secondary ICD10 | C79.8 | Secondary malignant neoplasm of other specified sites |
| 41204 | Diagnoses - secondary ICD10 | C79.9 | Secondary malignant neoplasm, unspecified site |
| 40001 | Underlying (primary) cause of death: ICD10 | C78.1 | Secondary malignant neoplasm of mediastinum |
| 40001 | Underlying (primary) cause of death: ICD10 | C78.3 | Secondary malignant neoplasm of other and unspecified respiratory organs |
| 40001 | Underlying (primary) cause of death: ICD10 | C78.8 | Secondary malignant neoplasm of other and unspecified digestive organs |
| 40001 | Underlying (primary) cause of death: ICD10 | C79.0 | Secondary malignant neoplasm of kidney and renal pelvis |
| 40001 | Underlying (primary) cause of death: ICD10 | C79.1 | Secondary malignant neoplasm of bladder and other and unspecified urinary organs |
| 40001 | Underlying (primary) cause of death: ICD10 | C79.2 | Secondary malignant neoplasm of skin |
| 40001 | Underlying (primary) cause of death: ICD10 | C79.6 | Secondary malignant neoplasm of ovary |
| 40001 | Underlying (primary) cause of death: ICD10 | C79.8 | Secondary malignant neoplasm of other specified sites |
| 40001 | Underlying (primary) cause of death: ICD10 | C79.9 | Secondary malignant neoplasm, unspecified site |
| 40002 | Contributory (secondary) causes of death: ICD10 | C78.1 | Secondary malignant neoplasm of mediastinum |
| 40002 | Contributory (secondary) causes of death: ICD10 | C78.3 | Secondary malignant neoplasm of other and unspecified respiratory organs |
| 40002 | Contributory (secondary) causes of death: ICD10 | C78.8 | Secondary malignant neoplasm of other and unspecified digestive organs |
| 40002 | Contributory (secondary) causes of death: ICD10 | C79.0 | Secondary malignant neoplasm of kidney and renal pelvis |
| 40002 | Contributory (secondary) causes of death: ICD10 | C79.1 | Secondary malignant neoplasm of bladder and other and unspecified urinary organs |
| 40002 | Contributory (secondary) causes of death: ICD10 | C79.2 | Secondary malignant neoplasm of skin |
| 40002 | Contributory (secondary) causes of death: ICD10 | C79.6 | Secondary malignant neoplasm of ovary |
| 40002 | Contributory (secondary) causes of death: ICD10 | C79.8 | Secondary malignant neoplasm of other specified sites |
| 40002 | Contributory (secondary) causes of death: ICD10 | C79.9 | Secondary malignant neoplasm, unspecified site |
| 42040 | GP clinical event records | 1D18.00 | Pain from metastases |
| 42040 | GP clinical event records | 5136.00 | X-ray metastasis control |
| 42040 | GP clinical event records | B571.00 | Secondary malignant neoplasm of mediastinum |
| 42040 | GP clinical event records | B573.00 | Secondary malignant neoplasm of other respiratory organs |
| 42040 | GP clinical event records | B57..00 | Secondary malig neop of respiratory and digestive systems |
| 42040 | GP clinical event records | B57..11 | Metastases of respiratory and/or digestive systems |
| 42040 | GP clinical event records | B57..12 | Secondary carcinoma of respiratory and/or digestive systems |
| 42040 | GP clinical event records | B57y.00 | Secondary malignant neoplasm of other digestive organ |
| 42040 | GP clinical event records | B57z.00 | Secondary malig neop of respiratory or digestive system NOS |
| 42040 | GP clinical event records | B580.00 | Secondary malignant neoplasm of kidney |
| 42040 | GP clinical event records | B581000 | Secondary malignant neoplasm of ureter |
| 42040 | GP clinical event records | B581100 | Secondary malignant neoplasm of bladder |
| 42040 | GP clinical event records | B581200 | Secondary malignant neoplasm of urethra |
| 42040 | GP clinical event records | B581.00 | Secondary malignant neoplasm of other urinary organs |
| 42040 | GP clinical event records | B581z00 | Secondary malignant neoplasm of other urinary organ NOS |
| 42040 | GP clinical event records | B582000 | Secondary malignant neoplasm of skin of head |
| 42040 | GP clinical event records | B582100 | Secondary malignant neoplasm of skin of face |
| 42040 | GP clinical event records | B582200 | Secondary malignant neoplasm of skin of neck |
| 42040 | GP clinical event records | B582300 | Secondary malignant neoplasm of skin of trunk |
| 42040 | GP clinical event records | B582400 | Secondary malignant neoplasm of skin of shoulder and arm |
| 42040 | GP clinical event records | B582500 | Secondary malignant neoplasm of skin of hip and leg |
| 42040 | GP clinical event records | B582600 | Secondary malignant neoplasm of skin of breast |
| 42040 | GP clinical event records | B582.00 | Secondary malignant neoplasm of skin |
| 42040 | GP clinical event records | B582z00 | Secondary malignant neoplasm of skin NOS |
| 42040 | GP clinical event records | B584.00 | Secondary malignant neoplasm of other part of nervous system |
| 42040 | GP clinical event records | B586.00 | Secondary malignant neoplasm of ovary |
| 42040 | GP clinical event records | B58..00 | Secondary malignant neoplasm of other specified sites |
| 42040 | GP clinical event records | B58..11 | Secondary carcinoma of other specified sites |
| 42040 | GP clinical event records | B58y000 | Secondary malignant neoplasm of breast |
| 42040 | GP clinical event records | B58y100 | Secondary malignant neoplasm of uterus |
| 42040 | GP clinical event records | B58y200 | Secondary malignant neoplasm of cervix uteri |
| 42040 | GP clinical event records | B58y211 | Secondary cancer of the cervix |
| 42040 | GP clinical event records | B58y300 | Secondary malignant neoplasm of vagina |
| 42040 | GP clinical event records | B58y400 | Secondary malignant neoplasm of vulva |
| 42040 | GP clinical event records | B58y411 | Secondary cancer of the vulva |
| 42040 | GP clinical event records | B58y500 | Secondary malignant neoplasm of prostate |
| 42040 | GP clinical event records | B58y600 | Secondary malignant neoplasm of testis |
| 42040 | GP clinical event records | B58y700 | Secondary malignant neoplasm of penis |
| 42040 | GP clinical event records | B58y800 | Secondary malignant neoplasm of epididymis and vas deferens |
| 42040 | GP clinical event records | B58y900 | Secondary malignant neoplasm of tongue |
| 42040 | GP clinical event records | B58y.00 | Secondary malignant neoplasm of other specified sites |
| 42040 | GP clinical event records | B58yz00 | Secondary malignant neoplasm of other specified site NOS |
| 42040 | GP clinical event records | B58z.00 | Secondary malignant neoplasm of other specified site NOS |
| 42040 | GP clinical event records | B590.00 | Disseminated malignancy NOS |
| 42040 | GP clinical event records | B590.11 | Carcinomatosis |
| 42040 | GP clinical event records | B594.00 | Secondary malignant neoplasm of unknown site |
| 42040 | GP clinical event records | BB03.00 | [M]Neoplasm, metastatic |
| 42040 | GP clinical event records | BB03.11 | [M]Secondary neoplasm |
| 42040 | GP clinical event records | BB13.00 | [M]Carcinoma, metastatic, NOS |
| 42040 | GP clinical event records | BB13.11 | [M]Secondary carcinoma |
| 42040 | GP clinical event records | BB2B.00 | [M]Squamous cell carcinoma, metastatic NOS |
| 42040 | GP clinical event records | BB53.00 | [M]Adenocarcinoma, metastatic, NOS |
| 42040 | GP clinical event records | BB85100 | [M]Metastatic signet ring cell carcinoma |
| 42040 | GP clinical event records | BBy2.00 | [M]No microscopic confirmation tumour, clinically metastatic |
| 42040 | GP clinical event records | ByuC300 | [X]Secondary malignant neoplasm/oth+unspc respiratory organs |
| 42040 | GP clinical event records | ByuC400 | [X]Secondary malignant neoplasm/oth+unspcfd digestive organs |
| 42040 | GP clinical event records | ByuC500 | [X]2ndry malignant neoplasm/bladder+oth+unsp urinary organs |
| 42040 | GP clinical event records | ByuC600 | [X]2ndry malignant neoplasm/oth+unspec parts/nervous system |
| 42040 | GP clinical event records | ByuC700 | [X]Secondary malignant neoplasm of other specified sites |
| 42040 | GP clinical event records | XM0pv | Secondary malignant neoplasm of unknown site |
| 42040 | GP clinical event records | XaC0y | Secondary malignant neoplasm of tongue |
| 42040 | GP clinical event records | XE1vn | Disseminated malignancy NOS |
| 42040 | GP clinical event records | XaFwL | Pain from metastases |
| 42040 | GP clinical event records | XE1wR | [M]Neoplasm, metastatic |
| 42040 | GP clinical event records | XE1wR | [M]Neoplasm, metastatic |
| 42040 | GP clinical event records | XE1vm | Secondary malignant neoplasm of respiratory and digestive systems |
| 42040 | GP clinical event records | XE1vm | Secondary malignant neoplasm of respiratory and digestive systems |
| 42040 | GP clinical event records | XE2vT | Secondary malignant neoplasm of other specified sites |
| 42040 | GP clinical event records | B58yz | Secondary malignant neoplasm of other specified site NOS |
| 42040 | GP clinical event records | XE2vT | Secondary malignant neoplasm of other specified sites |
| 40006 | Type of cancer: ICD10 | C78.1 | Secondary malignant neoplasm of mediastinum |
| 40006 | Type of cancer: ICD10 | C78.3 | Secondary malignant neoplasm of other and unspecified respiratory organs |
| 40006 | Type of cancer: ICD10 | C78.8 | Secondary malignant neoplasm of other and unspecified digestive organs |
| 40006 | Type of cancer: ICD10 | C79.0 | Secondary malignant neoplasm of kidney and renal pelvis |
| 40006 | Type of cancer: ICD10 | C79.1 | Secondary malignant neoplasm of bladder and other and unspecified urinary organs |
| 40006 | Type of cancer: ICD10 | C79.2 | Secondary malignant neoplasm of skin |
| 40006 | Type of cancer: ICD10 | C79.6 | Secondary malignant neoplasm of ovary |
| 40006 | Type of cancer: ICD10 | C79.8 | Secondary malignant neoplasm of other specified sites |
| 40006 | Type of cancer: ICD10 | C79.9 | Secondary malignant neoplasm, unspecified site |