| Name |
Secondary Malignancy of retroperitoneum and peritoneum (sec_peritoneum) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
96d99e2b-b01f-425b-bb18-b8c2fa62c287 |
| Definition |
Secondary Malignancy_retroperitoneum and peritoneum |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
3524 |
| Female (%) |
2298 (65%) |
| Male (%) |
1226 (35%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
5.19 (3.65,6.72) |
| Male |
0.7 (0.09,1.31) |
Incidence stratified by sex
| Female |
5.03 (4.44,5.61) |
| Male |
3.53 (3.0,4.07) |
Incidence stratified by age
| Ages 40-44 |
1.01 (0.38,1.63) |
| Ages 45-49 |
2.3 (1.49,3.11) |
| Ages 50-54 |
3.17 (2.29,4.04) |
| Ages 55-59 |
4.37 (3.43,5.3) |
| Ages 60-64 |
5.53 (4.63,6.43) |
| Ages 65-69 |
6.78 (5.64,7.92) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
9 (7,13) |
21 (17,24) |
37 (33,41) |
| CALIBER |
7 (6,8) |
19 (18,20) |
39 (37,41) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
15(8,27) |
16(10,25) |
45(36,55) |
| Low |
7(2,17) |
19(12,27) |
42(34,52) |
| Medium |
5(1,13) |
24(17,34) |
29(22,38) |
| High |
14(8,24) |
20(13,29) |
31(23,40) |
| Most deprived |
6(2,12) |
24(17,34) |
35(27,46) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
10(7,13) |
21(18,26) |
35(31,40) |
| Scotland |
7(2,19) |
12(6,21) |
37(27,51) |
| Wales |
10(2,29) |
29(17,47) |
47(32,66) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154057, Events=319
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.95 (0.73, 1.23) |
0.691 |
| BMI |
obese |
1.11 (0.83, 1.49) |
0.465 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.56 (1.21, 2) |
0.00057 |
| smoking |
current |
3.52 (2.62, 4.73) |
7.31e-17 |
| hypertension |
yes |
1.28 (1, 1.63) |
0.0477 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
C78.6 |
Secondary malignant neoplasm of retroperitoneum and peritoneum |
| 41204 |
Diagnoses - secondary ICD10 |
C78.6 |
Secondary malignant neoplasm of retroperitoneum and peritoneum |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C78.6 |
Secondary malignant neoplasm of retroperitoneum and peritoneum |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C78.6 |
Secondary malignant neoplasm of retroperitoneum and peritoneum |
| 42040 |
GP clinical event records |
B576000 |
Secondary malignant neoplasm of retroperitoneum |
| 42040 |
GP clinical event records |
B576100 |
Secondary malignant neoplasm of peritoneum |
| 42040 |
GP clinical event records |
B576200 |
Malignant ascites |
| 42040 |
GP clinical event records |
B576.00 |
Secondary malig neop of retroperitoneum and peritoneum |
| 42040 |
GP clinical event records |
B576z00 |
Secondary malig neop of retroperitoneum or peritoneum NOS |
| 42040 |
GP clinical event records |
X30AD |
Malignant ascites |
| 40006 |
Type of cancer: ICD10 |
C78.6 |
Secondary malignant neoplasm of retroperitoneum and peritoneum |