| Name |
Secondary Malignancy of Pleura (sec_pleura) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
e7f8964e-33ad-43e2-9664-5c4402591392 |
| Definition |
Secondary Malignancy_Pleura |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1628 |
| Female (%) |
1056 (65%) |
| Male (%) |
572 (35%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
1.18 (0.45,1.91) |
| Male |
0.28 (-0.11,0.67) |
Incidence stratified by sex
| Female |
2.21 (1.83,2.6) |
| Male |
1.94 (1.54,2.33) |
Incidence stratified by age
| Ages 40-44 |
0.4 (0.01,0.8) |
| Ages 45-49 |
0.82 (0.33,1.3) |
| Ages 50-54 |
1.39 (0.81,1.97) |
| Ages 55-59 |
2.75 (2.01,3.49) |
| Ages 60-64 |
2.57 (1.96,3.19) |
| Ages 65-69 |
3.06 (2.29,3.83) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
3 (2,5) |
9 (7,12) |
15 (12,17) |
| CALIBER |
3 (2,3) |
8 (7,9) |
17 (16,18) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
1(0,7) |
8(4,14) |
13(9,20) |
| Low |
3(0,9) |
10(5,17) |
17(11,23) |
| Medium |
5(1,13) |
9(4,15) |
13(8,19) |
| High |
4(1,11) |
8(4,14) |
12(7,18) |
| Most deprived |
2(0,7) |
12(7,20) |
19(13,28) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
3(2,6) |
10(7,13) |
15(12,18) |
| Scotland |
2(0,10) |
7(2,15) |
15(9,25) |
| Wales |
3(0,17) |
9(3,21) |
12(5,23) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154060, Events=218
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.89 (0.65, 1.23) |
0.488 |
| BMI |
obese |
1.16 (0.82, 1.63) |
0.404 |
| BMI |
underweight |
0 (0, Inf) |
0.989 |
| smoking |
previous |
1.75 (1.31, 2.35) |
0.000182 |
| smoking |
current |
2.37 (1.58, 3.55) |
3.07e-05 |
| hypertension |
yes |
1 (0.74, 1.36) |
0.997 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
C78.2 |
Secondary malignant neoplasm of pleura |
| 41204 |
Diagnoses - secondary ICD10 |
C78.2 |
Secondary malignant neoplasm of pleura |
| 40001 |
Underlying (primary) cause of death: ICD10 |
C78.2 |
Secondary malignant neoplasm of pleura |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
C78.2 |
Secondary malignant neoplasm of pleura |
| 42040 |
GP clinical event records |
B572.00 |
Secondary malignant neoplasm of pleura |
| 40006 |
Type of cancer: ICD10 |
C78.2 |
Secondary malignant neoplasm of pleura |