| Name |
Secondary pulmonary hypertension (sec_pulm_htn) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
6ac7758b-f15a-4cec-8f90-1e178828c077 |
| Definition |
Increased pressure of the blood vessels of the lungs as a result of other medical conditions. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1825 |
| Female (%) |
848 (46%) |
| Male (%) |
977 (54%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
1.18 (0.45,1.91) |
| Male |
0.56 (0.01,1.11) |
Incidence stratified by sex
| Female |
1.16 (0.88,1.44) |
| Male |
1.54 (1.18,1.89) |
Incidence stratified by age
| Ages 40-44 |
0.3 (-0.04,0.64) |
| Ages 45-49 |
0.59 (0.18,1.0) |
| Ages 50-54 |
0.57 (0.2,0.94) |
| Ages 55-59 |
0.83 (0.42,1.24) |
| Ages 60-64 |
1.77 (1.26,2.28) |
| Ages 65-69 |
2.86 (2.12,3.6) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
4 (2,6) |
5 (3,7) |
12 (10,15) |
| CALIBER |
3 (3,4) |
8 (7,9) |
17 (16,18) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
2(0,9) |
4(1,8) |
6(3,11) |
| Low |
2(0,9) |
6(3,12) |
13(8,19) |
| Medium |
5(1,14) |
2(0,6) |
13(8,19) |
| High |
5(2,13) |
7(3,14) |
12(7,19) |
| Most deprived |
5(2,11) |
5(2,10) |
20(14,29) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
4(2,7) |
5(3,7) |
13(11,16) |
| Scotland |
0(NaN,NaN) |
3(1,10) |
9(4,17) |
| Wales |
6(1,22) |
7(2,18) |
10(4,21) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=147230, Events=709
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.31 (1.08, 1.58) |
0.00511 |
| BMI |
obese |
1.42 (1.15, 1.75) |
0.0011 |
| BMI |
underweight |
0 (0, Inf) |
0.982 |
| smoking |
previous |
1.11 (0.94, 1.32) |
0.217 |
| smoking |
current |
2.52 (2.07, 3.07) |
3.95e-20 |
| hypertension |
yes |
1.42 (1.21, 1.67) |
1.57e-05 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
I27.2 |
Other secondary pulmonary hypertension |
| 41204 |
Diagnoses - secondary ICD10 |
I27.2 |
Other secondary pulmonary hypertension |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I27.2 |
Other secondary pulmonary hypertension |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I27.2 |
Other secondary pulmonary hypertension |
| 42040 |
GP clinical event records |
G41y000 |
Secondary pulmonary hypertension |
| 42040 |
GP clinical event records |
G41y100 |
Thromboembolic pulmonary hypertension |
| 42040 |
GP clinical event records |
X203A |
Thromboembolic pulmonary hypertension |