Septicaemia

Metadata

Name	Septicaemia (sepsis)
Category	Infections
Sex
Adult	Yes
UUID	ecd214bc-0b19-4057-a3f4-c330df26ebf6
Definition	Systemic inflammatory response syndrome with a proven or suspected infectious etiology.

Ontologies

Disease Ontology (DOID)	DOID_0040085
GWAS Catalogue	HP_0100806
MeSH	D018805
SNOMED-CT	91302008
FinnGen	AB1_SEPSIS

Key Summary Statistics

Cases from any source

Total	15510
Female (%)	6800 (44%)
Male (%)	8710 (56%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	26.76 (23.28,30.23)
Male	38.22 (33.69,42.74)

Incidence stratified by sex

Female	11.17 (10.3,12.04)
Male	15.78 (14.65,16.92)

Incidence stratified by age

Ages 40-44	4.84 (3.47,6.21)
Ages 45-49	5.06 (3.85,6.26)
Ages 50-54	9.65 (8.12,11.19)
Ages 55-59	12.99 (11.38,14.6)
Ages 60-64	16.95 (15.37,18.54)
Ages 65-69	21.38 (19.34,23.42)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	47 (41,54)	76 (70,83)	131 (123,138)
CALIBER	52 (50,54)	89 (86,91)	169 (165,173)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	28(17,43)	64(51,80)	111(96,127)
Low	37(24,54)	71(57,87)	118(103,134)
Medium	52(37,71)	62(49,77)	117(102,134)
High	52(38,69)	78(64,95)	146(128,165)
Most deprived	60(46,77)	106(89,125)	170(150,192)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	46(39,54)	81(74,89)	130(122,139)
Scotland	52(34,76)	61(46,79)	130(110,154)
Wales	57(33,92)	54(35,78)	134(108,164)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.18 (0.74, 1.86)	0.489
BMI	obese	1.91 (1.2, 3.06)	0.00685
BMI	underweight	0 (0, Inf)	0.995
smoking	previous	1.29 (0.88, 1.87)	0.189
smoking	current	1.41 (0.81, 2.45)	0.23
hypertension	yes	1.93 (1.34, 2.77)	0.000403

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1657	septicaemia / sepsis
41202	Diagnoses - main ICD10	A02.1	Salmonella sepsis
41202	Diagnoses - main ICD10	A20.7	Septicaemic plague
41202	Diagnoses - main ICD10	A22.7	Anthrax sepsis
41202	Diagnoses - main ICD10	A26.7	Erysipelothrix sepsis
41202	Diagnoses - main ICD10	A32.7	Listerial sepsis
41202	Diagnoses - main ICD10	A39.1	Waterhouse-Friderichsen syndrome
41202	Diagnoses - main ICD10	A39.2	Acute meningococcaemia
41202	Diagnoses - main ICD10	A39.3	Chronic meningococcaemia
41202	Diagnoses - main ICD10	A39.4	Meningococcaemia, unspecified
41202	Diagnoses - main ICD10	A40	Streptococcal sepsis
41202	Diagnoses - main ICD10	A41	Other sepsis
41202	Diagnoses - main ICD10	A42.7	Actinomycotic sepsis
41202	Diagnoses - main ICD10	B37.7	Candidal sepsis
41202	Diagnoses - main ICD10	P36	Bacterial sepsis of newborn
41204	Diagnoses - secondary ICD10	A02.1	Salmonella sepsis
41204	Diagnoses - secondary ICD10	A20.7	Septicaemic plague
41204	Diagnoses - secondary ICD10	A22.7	Anthrax sepsis
41204	Diagnoses - secondary ICD10	A26.7	Erysipelothrix sepsis
41204	Diagnoses - secondary ICD10	A32.7	Listerial sepsis
41204	Diagnoses - secondary ICD10	A39.1	Waterhouse-Friderichsen syndrome
41204	Diagnoses - secondary ICD10	A39.2	Acute meningococcaemia
41204	Diagnoses - secondary ICD10	A39.3	Chronic meningococcaemia
41204	Diagnoses - secondary ICD10	A39.4	Meningococcaemia, unspecified
41204	Diagnoses - secondary ICD10	A40	Streptococcal sepsis
41204	Diagnoses - secondary ICD10	A41	Other sepsis
41204	Diagnoses - secondary ICD10	A42.7	Actinomycotic sepsis
41204	Diagnoses - secondary ICD10	B37.7	Candidal sepsis
41204	Diagnoses - secondary ICD10	P36	Bacterial sepsis of newborn
40001	Underlying (primary) cause of death: ICD10	A02.1	Salmonella sepsis
40001	Underlying (primary) cause of death: ICD10	A20.7	Septicaemic plague
40001	Underlying (primary) cause of death: ICD10	A22.7	Anthrax sepsis
40001	Underlying (primary) cause of death: ICD10	A26.7	Erysipelothrix sepsis
40001	Underlying (primary) cause of death: ICD10	A32.7	Listerial sepsis
40001	Underlying (primary) cause of death: ICD10	A39.1	Waterhouse-Friderichsen syndrome
40001	Underlying (primary) cause of death: ICD10	A39.2	Acute meningococcaemia
40001	Underlying (primary) cause of death: ICD10	A39.3	Chronic meningococcaemia
40001	Underlying (primary) cause of death: ICD10	A39.4	Meningococcaemia, unspecified
40001	Underlying (primary) cause of death: ICD10	A40	Streptococcal sepsis
40001	Underlying (primary) cause of death: ICD10	A41	Other sepsis
40001	Underlying (primary) cause of death: ICD10	A42.7	Actinomycotic sepsis
40001	Underlying (primary) cause of death: ICD10	B37.7	Candidal sepsis
40001	Underlying (primary) cause of death: ICD10	P36	Bacterial sepsis of newborn
40002	Contributory (secondary) causes of death: ICD10	A02.1	Salmonella sepsis
40002	Contributory (secondary) causes of death: ICD10	A20.7	Septicaemic plague
40002	Contributory (secondary) causes of death: ICD10	A22.7	Anthrax sepsis
40002	Contributory (secondary) causes of death: ICD10	A26.7	Erysipelothrix sepsis
40002	Contributory (secondary) causes of death: ICD10	A32.7	Listerial sepsis
40002	Contributory (secondary) causes of death: ICD10	A39.1	Waterhouse-Friderichsen syndrome
40002	Contributory (secondary) causes of death: ICD10	A39.2	Acute meningococcaemia
40002	Contributory (secondary) causes of death: ICD10	A39.3	Chronic meningococcaemia
40002	Contributory (secondary) causes of death: ICD10	A39.4	Meningococcaemia, unspecified
40002	Contributory (secondary) causes of death: ICD10	A40	Streptococcal sepsis
40002	Contributory (secondary) causes of death: ICD10	A41	Other sepsis
40002	Contributory (secondary) causes of death: ICD10	A42.7	Actinomycotic sepsis
40002	Contributory (secondary) causes of death: ICD10	B37.7	Candidal sepsis
40002	Contributory (secondary) causes of death: ICD10	P36	Bacterial sepsis of newborn