| Name |
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) |
| Category |
Endocrine |
| Sex |
|
| Adult |
Yes |
| UUID |
7fb81fdf-4053-46e4-8ff9-d045d25b198b |
| Definition |
A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
582 |
| Female (%) |
280 (48%) |
| Male (%) |
302 (52%) |
Year first recorded
Cases linked in all UK Biobank sources
*All 103 cases from Hospital EHR*
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
0.59 (0.07,1.11) |
| Male |
1.26 (0.44,2.08) |
Incidence stratified by sex
| Female |
0.39 (0.22,0.55) |
| Male |
0.72 (0.47,0.96) |
Incidence stratified by age
| Ages 40-44 |
0.0 (0.0,0.0) |
| Ages 45-49 |
0.0 (0.0,0.0) |
| Ages 50-54 |
0.51 (0.16,0.86) |
| Ages 55-59 |
0.36 (0.09,0.63) |
| Ages 60-64 |
0.81 (0.46,1.15) |
| Ages 65-69 |
1.0 (0.56,1.44) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
1 (0,2) |
2 (1,4) |
6 (4,7) |
| CALIBER |
– |
3 (2,3) |
7 (6,8) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
0(NaN,NaN) |
2(0,6) |
4(2,8) |
| Low |
0(NaN,NaN) |
3(1,9) |
5(2,9) |
| Medium |
0(NaN,NaN) |
2(0,6) |
6(3,10) |
| High |
0(NaN,NaN) |
3(1,8) |
4(1,8) |
| Most deprived |
2(0,7) |
1(0,5) |
10(6,17) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
0(0,2) |
2(1,4) |
6(4,8) |
| Scotland |
2(0,13) |
2(0,7) |
4(1,10) |
| Wales |
0(NaN,NaN) |
0(NaN,NaN) |
7(2,17) |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
E22.2 |
Syndrome of inappropriate secretion of antidiuretic hormone |
| 41204 |
Diagnoses - secondary ICD10 |
E22.2 |
Syndrome of inappropriate secretion of antidiuretic hormone |
| 40001 |
Underlying (primary) cause of death: ICD10 |
E22.2 |
Syndrome of inappropriate secretion of antidiuretic hormone |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
E22.2 |
Syndrome of inappropriate secretion of antidiuretic hormone |