| Name |
Sick sinus syndrome (sick_sinus) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
6674a0a2-0668-4543-aadb-b66d816f92ca |
| Definition |
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1302 |
| Female (%) |
556 (43%) |
| Male (%) |
746 (57%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
4.6 (3.15,6.04) |
| Male |
7.7 (5.67,9.73) |
Incidence stratified by sex
| Female |
1.05 (0.79,1.32) |
| Male |
1.71 (1.33,2.08) |
Incidence stratified by age
| Ages 40-44 |
0.1 (-0.1,0.3) |
| Ages 45-49 |
0.44 (0.09,0.8) |
| Ages 50-54 |
0.63 (0.24,1.03) |
| Ages 55-59 |
0.73 (0.35,1.11) |
| Ages 60-64 |
1.92 (1.39,2.45) |
| Ages 65-69 |
3.02 (2.25,3.78) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
3 (2,6) |
8 (6,10) |
20 (17,23) |
| CALIBER |
2 (2,3) |
5 (4,6) |
15 (14,16) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
7(2,15) |
9(4,15) |
21(15,29) |
| Low |
3(0,10) |
9(4,16) |
18(13,25) |
| Medium |
4(1,11) |
7(3,13) |
16(11,23) |
| High |
1(0,7) |
6(3,12) |
21(14,29) |
| Most deprived |
2(0,7) |
8(4,15) |
24(17,33) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
4(2,6) |
8(6,11) |
18(15,22) |
| Scotland |
2(0,10) |
6(2,14) |
22(14,34) |
| Wales |
4(0,21) |
6(1,18) |
31(19,47) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153979, Events=141
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.41 (0.92, 2.17) |
0.113 |
| BMI |
obese |
1.52 (0.95, 2.43) |
0.0832 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
0.89 (0.63, 1.27) |
0.531 |
| smoking |
current |
0.83 (0.44, 1.56) |
0.561 |
| hypertension |
yes |
1.5 (1.06, 2.12) |
0.0207 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1486 |
sick sinus syndrome |
| 41202 |
Diagnoses - main ICD10 |
I49.5 |
Sick sinus syndrome |
| 41204 |
Diagnoses - secondary ICD10 |
I49.5 |
Sick sinus syndrome |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I49.5 |
Sick sinus syndrome |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I49.5 |
Sick sinus syndrome |
| 42040 |
GP clinical event records |
G57y300 |
Sick sinus syndrome |
| 42040 |
GP clinical event records |
G57y400 |
Sinoatrial node dysfunction NOS |