Name |
Sickle-cell trait (sickle_trait) |
Category |
Haematological or immunological |
Sex |
|
Adult |
Yes |
UUID |
f8c713d4-a4ad-4795-91ab-a27e81a84251 |
Definition |
People who inherit one sickle cell gene and one normal gene have sickle cell trait (SCT). |
Ontologies
Key Summary Statistics
Cases from any source
Total |
584 |
Female (%) |
415 (71%) |
Male (%) |
169 (29%) |
Year first recorded

Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex
Female |
8.25 (6.32,10.18) |
Male |
3.92 (2.47,5.37) |
Incidence stratified by sex
Female |
0.6 (0.4,0.8) |
Male |
0.32 (0.16,0.48) |
Incidence stratified by age
Ages 40-44 |
0.5 (0.06,0.94) |
Ages 45-49 |
1.04 (0.49,1.58) |
Ages 50-54 |
0.44 (0.11,0.77) |
Ages 55-59 |
0.47 (0.16,0.77) |
Ages 60-64 |
0.38 (0.15,0.62) |
Ages 65-69 |
0.2 (0.0,0.4) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
UK Biobank |
12 (9,16) |
9 (6,11) |
4 (3,6) |
CALIBER |
21 (20,22) |
10 (9,11) |
5 (4,6) |
Stratified by age and Townsend deprivation status
Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
Least deprived |
6(2,14) |
1(0,4) |
0(0,3) |
Low |
3(0,9) |
4(1,9) |
3(1,7) |
Medium |
8(3,17) |
3(1,8) |
3(1,7) |
High |
8(4,17) |
6(3,11) |
5(2,9) |
Most deprived |
30(21,43) |
29(21,39) |
12(7,18) |
Stratified by age and country
Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
England |
13(10,18) |
10(8,13) |
5(4,7) |
Scotland |
4(0,15) |
2(0,7) |
0(NaN,NaN) |
Wales |
13(3,33) |
3(0,12) |
1(0,8) |
Definition
UK Biobank field id |
Description |
Code |
Value |
41202 |
Diagnoses - main ICD10 |
D57.3 |
Sickle-cell trait |
41204 |
Diagnoses - secondary ICD10 |
D57.3 |
Sickle-cell trait |
40001 |
Underlying (primary) cause of death: ICD10 |
D57.3 |
Sickle-cell trait |
40002 |
Contributory (secondary) causes of death: ICD10 |
D57.3 |
Sickle-cell trait |
42040 |
GP clinical event records |
677C600 |
Sickle cell gene carrier |
42040 |
GP clinical event records |
D105.00 |
Sickle-cell trait |
42040 |
GP clinical event records |
XaQ22 |
Sickle cell gene carrier |