Metadata

Name Sickle-cell trait (sickle_trait)
Category Haematological or immunological
Sex
Adult Yes
UUID f8c713d4-a4ad-4795-91ab-a27e81a84251
Definition People who inherit one sickle cell gene and one normal gene have sickle cell trait (SCT).

Ontologies

MeSH D012805
SNOMED-CT 16402000
FinnGen D3_SICKLECELLDIS

Key Summary Statistics

Cases from any source

Total 584
Female (%) 415 (71%)
Male (%) 169 (29%)

Year first recorded

sickle_trait year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced sickle_trait cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of sickle_trait

Baseline prevalence stratified by sex

Female 8.25 (6.32,10.18)
Male 3.92 (2.47,5.37)

Incidence stratified by sex

Female 0.6 (0.4,0.8)
Male 0.32 (0.16,0.48)

Incidence stratified by age

Ages 40-44 0.5 (0.06,0.94)
Ages 45-49 1.04 (0.49,1.58)
Ages 50-54 0.44 (0.11,0.77)
Ages 55-59 0.47 (0.16,0.77)
Ages 60-64 0.38 (0.15,0.62)
Ages 65-69 0.2 (0.0,0.4)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB sickle_trait prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 12 (9,16) 9 (6,11) 4 (3,6)
CALIBER 21 (20,22) 10 (9,11) 5 (4,6)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 6(2,14) 1(0,4) 0(0,3)
Low 3(0,9) 4(1,9) 3(1,7)
Medium 8(3,17) 3(1,8) 3(1,7)
High 8(4,17) 6(3,11) 5(2,9)
Most deprived 30(21,43) 29(21,39) 12(7,18)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 13(10,18) 10(8,13) 5(4,7)
Scotland 4(0,15) 2(0,7) 0(NaN,NaN)
Wales 13(3,33) 3(0,12) 1(0,8)

Definition

UK Biobank field id Description Code Value
41202 Diagnoses - main ICD10 D57.3 Sickle-cell trait
41204 Diagnoses - secondary ICD10 D57.3 Sickle-cell trait
40001 Underlying (primary) cause of death: ICD10 D57.3 Sickle-cell trait
40002 Contributory (secondary) causes of death: ICD10 D57.3 Sickle-cell trait
42040 GP clinical event records 677C600 Sickle cell gene carrier
42040 GP clinical event records D105.00 Sickle-cell trait
42040 GP clinical event records XaQ22 Sickle cell gene carrier