| Name |
Sjogren’s disease (sjogren) |
| Category |
Musculoskeletal |
| Sex |
|
| Adult |
Yes |
| UUID |
752378a9-8d4c-4ef8-8e4e-a3b94eba7273 |
| Definition |
Sjogren syndrome An autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjogren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjogren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1487 |
| Female (%) |
1326 (89%) |
| Male (%) |
161 (11%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
27.47 (23.94,30.99) |
| Male |
2.38 (1.25,3.51) |
Incidence stratified by sex
| Female |
1.74 (1.4,2.09) |
| Male |
0.36 (0.19,0.53) |
Incidence stratified by age
| Ages 40-44 |
0.7 (0.18,1.23) |
| Ages 45-49 |
0.74 (0.28,1.2) |
| Ages 50-54 |
1.33 (0.76,1.9) |
| Ages 55-59 |
1.2 (0.71,1.69) |
| Ages 60-64 |
1.04 (0.65,1.43) |
| Ages 65-69 |
1.41 (0.89,1.93) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
7 (5,11) |
18 (15,21) |
22 (19,25) |
| CALIBER |
8 (7,9) |
16 (15,17) |
26 (24,27) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
4(1,11) |
15(10,23) |
19(13,25) |
| Low |
6(2,15) |
15(9,23) |
27(20,35) |
| Medium |
9(3,18) |
18(12,26) |
19(14,27) |
| High |
7(3,15) |
16(10,23) |
22(16,30) |
| Most deprived |
10(5,18) |
26(19,36) |
23(16,31) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
7(4,10) |
16(13,20) |
21(18,24) |
| Scotland |
11(4,24) |
29(19,41) |
27(19,39) |
| Wales |
10(2,31) |
13(6,26) |
27(16,42) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153824, Events=116
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.57 (0.36, 0.9) |
0.0161 |
| BMI |
obese |
1.07 (0.69, 1.66) |
0.75 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
0.88 (0.59, 1.31) |
0.524 |
| smoking |
current |
0.55 (0.24, 1.26) |
0.159 |
| hypertension |
yes |
1.81 (1.22, 2.71) |
0.00355 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1382 |
sjogren’s syndrome/sicca syndrome |
| 41202 |
Diagnoses - main ICD10 |
M35.0 |
Sicca syndrome [Sjogren] |
| 41204 |
Diagnoses - secondary ICD10 |
M35.0 |
Sicca syndrome [Sjogren] |
| 40001 |
Underlying (primary) cause of death: ICD10 |
M35.0 |
Sicca syndrome [Sjogren] |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
M35.0 |
Sicca syndrome [Sjogren] |
| 42040 |
GP clinical event records |
F396700 |
Myopathy due to Sjogren’s disease |
| 42040 |
GP clinical event records |
H57y300 |
Lung disease with Sjogren’s disease |
| 42040 |
GP clinical event records |
N002.00 |
Sicca (Sjogren’s) syndrome |