Metadata

Name Infection of skin and subcutaneous tissues (skin)
Category Infections
Sex
Adult Yes
UUID ddee9853-c8ed-4809-b96e-c023e7d88552
Definition Infection of skin and subcutaneous tissues

Ontologies

MeSH D012874
SNOMED-CT 19824006
FinnGen L12_INFECT_SKIN

Key Summary Statistics

Cases from any source

Total 22950
Female (%) 10419 (45%)
Male (%) 12531 (55%)

Year first recorded

skin year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced skin cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of skin

Baseline prevalence stratified by sex

Female 117.41 (110.16,124.65)
Male 190.25 (180.23,200.27)

Incidence stratified by sex

Female 16.95 (15.87,18.02)
Male 26.45 (24.97,27.93)

Incidence stratified by age

Ages 40-44 15.34 (12.89,17.8)
Ages 45-49 17.29 (15.05,19.53)
Ages 50-54 18.66 (16.51,20.82)
Ages 55-59 20.6 (18.55,22.65)
Ages 60-64 23.48 (21.6,25.36)
Ages 65-69 26.67 (24.37,28.96)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB skin prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 236 (221,251) 286 (273,299) 325 (313,337)
CALIBER 237 (233,241) 270 (265,275) 343 (337,349)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 192(161,228) 227(201,254) 243(222,267)
Low 213(180,251) 237(210,265) 299(275,324)
Medium 215(183,252) 263(236,293) 299(274,325)
High 215(185,248) 296(267,327) 356(328,386)
Most deprived 317(283,353) 401(367,436) 453(420,488)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 234(218,251) 290(275,305) 329(316,343)
Scotland 257(214,306) 270(236,307) 289(257,323)
Wales 225(174,286) 268(225,317) 336(293,382)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor Level Hazard Ratio P value
BMI overweight 1.18 (0.74, 1.86) 0.489
BMI obese 1.91 (1.2, 3.06) 0.00685
BMI underweight 0 (0, Inf) 0.995
smoking previous 1.29 (0.88, 1.87) 0.189
smoking current 1.41 (0.81, 2.45) 0.23
hypertension yes 1.93 (1.34, 2.77) 0.000403

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1625 cellulitis
41202 Diagnoses - main ICD10 A06.7 Cutaneous amoebiasis
41202 Diagnoses - main ICD10 A18.4 Tuberculosis of skin and subcutaneous tissue
41202 Diagnoses - main ICD10 A20.1 Cellulocutaneous plague
41202 Diagnoses - main ICD10 A21.0 Ulceroglandular tularaemia
41202 Diagnoses - main ICD10 A22.0 Cutaneous anthrax
41202 Diagnoses - main ICD10 A26.0 Cutaneous erysipeloid
41202 Diagnoses - main ICD10 A31.1 Cutaneous mycobacterial infection
41202 Diagnoses - main ICD10 A32.0 Cutaneous listeriosis
41202 Diagnoses - main ICD10 A36.3 Cutaneous diphtheria
41202 Diagnoses - main ICD10 A43.1 Cutaneous nocardiosis
41202 Diagnoses - main ICD10 A46 Erysipelas
41202 Diagnoses - main ICD10 A51.3 Secondary syphilis of skin and mucous membranes
41202 Diagnoses - main ICD10 B00.0 Eczema herpeticum
41202 Diagnoses - main ICD10 B00.1 Herpesviral vesicular dermatitis
41202 Diagnoses - main ICD10 B07 Viral warts
41202 Diagnoses - main ICD10 B08 Other viral infections characterized by skin and mucous membrane lesions, not elsewhere classified
41202 Diagnoses - main ICD10 B09 Unspecified viral infection characterized by skin and mucous membrane lesions
41202 Diagnoses - main ICD10 B35 Dermatophytosis
41202 Diagnoses - main ICD10 B36 Other superficial mycoses
41202 Diagnoses - main ICD10 B37.2 Candidiasis of skin and nail
41202 Diagnoses - main ICD10 B38.3 Cutaneous coccidioidomycosis
41202 Diagnoses - main ICD10 B40.3 Cutaneous blastomycosis
41202 Diagnoses - main ICD10 B42.1 Lymphocutaneous sporotrichosis
41202 Diagnoses - main ICD10 B43.0 Cutaneous chromomycosis
41202 Diagnoses - main ICD10 B43.2 Subcutaneous phaeomycotic abscess and cyst
41202 Diagnoses - main ICD10 B45.2 Cutaneous cryptococcosis
41202 Diagnoses - main ICD10 B46.3 Cutaneous mucormycosis
41202 Diagnoses - main ICD10 B55.1 Cutaneous leishmaniasis
41202 Diagnoses - main ICD10 B78.1 Cutaneous strongyloidiasis
41202 Diagnoses - main ICD10 B85 Pediculosis and phthiriasis
41202 Diagnoses - main ICD10 B86 Scabies
41202 Diagnoses - main ICD10 B87.0 Cutaneous myiasis
41202 Diagnoses - main ICD10 B87.1 Wound myiasis
41202 Diagnoses - main ICD10 B88 Other infestations
41202 Diagnoses - main ICD10 L00 Staphylococcal scalded skin syndrome
41202 Diagnoses - main ICD10 L01 Impetigo
41202 Diagnoses - main ICD10 L02 Cutaneous abscess, furuncle and carbuncle
41202 Diagnoses - main ICD10 L03 Cellulitis
41202 Diagnoses - main ICD10 L05.0 Pilonidal cyst with abscess
41202 Diagnoses - main ICD10 L08 Other local infections of skin and subcutaneous tissue
41202 Diagnoses - main ICD10 L30.3 Infective dermatitis
41202 Diagnoses - main ICD10 P38 Omphalitis of newborn with or without mild haemorrhage
41202 Diagnoses - main ICD10 P39.4 Neonatal skin infection
41204 Diagnoses - secondary ICD10 A06.7 Cutaneous amoebiasis
41204 Diagnoses - secondary ICD10 A18.4 Tuberculosis of skin and subcutaneous tissue
41204 Diagnoses - secondary ICD10 A20.1 Cellulocutaneous plague
41204 Diagnoses - secondary ICD10 A21.0 Ulceroglandular tularaemia
41204 Diagnoses - secondary ICD10 A22.0 Cutaneous anthrax
41204 Diagnoses - secondary ICD10 A26.0 Cutaneous erysipeloid
41204 Diagnoses - secondary ICD10 A31.1 Cutaneous mycobacterial infection
41204 Diagnoses - secondary ICD10 A32.0 Cutaneous listeriosis
41204 Diagnoses - secondary ICD10 A36.3 Cutaneous diphtheria
41204 Diagnoses - secondary ICD10 A43.1 Cutaneous nocardiosis
41204 Diagnoses - secondary ICD10 A46 Erysipelas
41204 Diagnoses - secondary ICD10 A51.3 Secondary syphilis of skin and mucous membranes
41204 Diagnoses - secondary ICD10 B00.0 Eczema herpeticum
41204 Diagnoses - secondary ICD10 B00.1 Herpesviral vesicular dermatitis
41204 Diagnoses - secondary ICD10 B07 Viral warts
41204 Diagnoses - secondary ICD10 B08 Other viral infections characterized by skin and mucous membrane lesions, not elsewhere classified
41204 Diagnoses - secondary ICD10 B09 Unspecified viral infection characterized by skin and mucous membrane lesions
41204 Diagnoses - secondary ICD10 B35 Dermatophytosis
41204 Diagnoses - secondary ICD10 B36 Other superficial mycoses
41204 Diagnoses - secondary ICD10 B37.2 Candidiasis of skin and nail
41204 Diagnoses - secondary ICD10 B38.3 Cutaneous coccidioidomycosis
41204 Diagnoses - secondary ICD10 B40.3 Cutaneous blastomycosis
41204 Diagnoses - secondary ICD10 B42.1 Lymphocutaneous sporotrichosis
41204 Diagnoses - secondary ICD10 B43.0 Cutaneous chromomycosis
41204 Diagnoses - secondary ICD10 B43.2 Subcutaneous phaeomycotic abscess and cyst
41204 Diagnoses - secondary ICD10 B45.2 Cutaneous cryptococcosis
41204 Diagnoses - secondary ICD10 B46.3 Cutaneous mucormycosis
41204 Diagnoses - secondary ICD10 B55.1 Cutaneous leishmaniasis
41204 Diagnoses - secondary ICD10 B78.1 Cutaneous strongyloidiasis
41204 Diagnoses - secondary ICD10 B85 Pediculosis and phthiriasis
41204 Diagnoses - secondary ICD10 B86 Scabies
41204 Diagnoses - secondary ICD10 B87.0 Cutaneous myiasis
41204 Diagnoses - secondary ICD10 B87.1 Wound myiasis
41204 Diagnoses - secondary ICD10 B88 Other infestations
41204 Diagnoses - secondary ICD10 L00 Staphylococcal scalded skin syndrome
41204 Diagnoses - secondary ICD10 L01 Impetigo
41204 Diagnoses - secondary ICD10 L02 Cutaneous abscess, furuncle and carbuncle
41204 Diagnoses - secondary ICD10 L03 Cellulitis
41204 Diagnoses - secondary ICD10 L05.0 Pilonidal cyst with abscess
41204 Diagnoses - secondary ICD10 L08 Other local infections of skin and subcutaneous tissue
41204 Diagnoses - secondary ICD10 L30.3 Infective dermatitis
41204 Diagnoses - secondary ICD10 P38 Omphalitis of newborn with or without mild haemorrhage
41204 Diagnoses - secondary ICD10 P39.4 Neonatal skin infection
40001 Underlying (primary) cause of death: ICD10 A06.7 Cutaneous amoebiasis
40001 Underlying (primary) cause of death: ICD10 A18.4 Tuberculosis of skin and subcutaneous tissue
40001 Underlying (primary) cause of death: ICD10 A20.1 Cellulocutaneous plague
40001 Underlying (primary) cause of death: ICD10 A21.0 Ulceroglandular tularaemia
40001 Underlying (primary) cause of death: ICD10 A22.0 Cutaneous anthrax
40001 Underlying (primary) cause of death: ICD10 A26.0 Cutaneous erysipeloid
40001 Underlying (primary) cause of death: ICD10 A31.1 Cutaneous mycobacterial infection
40001 Underlying (primary) cause of death: ICD10 A32.0 Cutaneous listeriosis
40001 Underlying (primary) cause of death: ICD10 A36.3 Cutaneous diphtheria
40001 Underlying (primary) cause of death: ICD10 A43.1 Cutaneous nocardiosis
40001 Underlying (primary) cause of death: ICD10 A46 Erysipelas
40001 Underlying (primary) cause of death: ICD10 A51.3 Secondary syphilis of skin and mucous membranes
40001 Underlying (primary) cause of death: ICD10 B00.0 Eczema herpeticum
40001 Underlying (primary) cause of death: ICD10 B00.1 Herpesviral vesicular dermatitis
40001 Underlying (primary) cause of death: ICD10 B07 Viral warts
40001 Underlying (primary) cause of death: ICD10 B08 Other viral infections characterized by skin and mucous membrane lesions, not elsewhere classified
40001 Underlying (primary) cause of death: ICD10 B09 Unspecified viral infection characterized by skin and mucous membrane lesions
40001 Underlying (primary) cause of death: ICD10 B35 Dermatophytosis
40001 Underlying (primary) cause of death: ICD10 B36 Other superficial mycoses
40001 Underlying (primary) cause of death: ICD10 B37.2 Candidiasis of skin and nail
40001 Underlying (primary) cause of death: ICD10 B38.3 Cutaneous coccidioidomycosis
40001 Underlying (primary) cause of death: ICD10 B40.3 Cutaneous blastomycosis
40001 Underlying (primary) cause of death: ICD10 B42.1 Lymphocutaneous sporotrichosis
40001 Underlying (primary) cause of death: ICD10 B43.0 Cutaneous chromomycosis
40001 Underlying (primary) cause of death: ICD10 B43.2 Subcutaneous phaeomycotic abscess and cyst
40001 Underlying (primary) cause of death: ICD10 B45.2 Cutaneous cryptococcosis
40001 Underlying (primary) cause of death: ICD10 B46.3 Cutaneous mucormycosis
40001 Underlying (primary) cause of death: ICD10 B55.1 Cutaneous leishmaniasis
40001 Underlying (primary) cause of death: ICD10 B78.1 Cutaneous strongyloidiasis
40001 Underlying (primary) cause of death: ICD10 B85 Pediculosis and phthiriasis
40001 Underlying (primary) cause of death: ICD10 B86 Scabies
40001 Underlying (primary) cause of death: ICD10 B87.0 Cutaneous myiasis
40001 Underlying (primary) cause of death: ICD10 B87.1 Wound myiasis
40001 Underlying (primary) cause of death: ICD10 B88 Other infestations
40001 Underlying (primary) cause of death: ICD10 L00 Staphylococcal scalded skin syndrome
40001 Underlying (primary) cause of death: ICD10 L01 Impetigo
40001 Underlying (primary) cause of death: ICD10 L02 Cutaneous abscess, furuncle and carbuncle
40001 Underlying (primary) cause of death: ICD10 L03 Cellulitis
40001 Underlying (primary) cause of death: ICD10 L05.0 Pilonidal cyst with abscess
40001 Underlying (primary) cause of death: ICD10 L08 Other local infections of skin and subcutaneous tissue
40001 Underlying (primary) cause of death: ICD10 L30.3 Infective dermatitis
40001 Underlying (primary) cause of death: ICD10 P38 Omphalitis of newborn with or without mild haemorrhage
40001 Underlying (primary) cause of death: ICD10 P39.4 Neonatal skin infection
40002 Contributory (secondary) causes of death: ICD10 A06.7 Cutaneous amoebiasis
40002 Contributory (secondary) causes of death: ICD10 A18.4 Tuberculosis of skin and subcutaneous tissue
40002 Contributory (secondary) causes of death: ICD10 A20.1 Cellulocutaneous plague
40002 Contributory (secondary) causes of death: ICD10 A21.0 Ulceroglandular tularaemia
40002 Contributory (secondary) causes of death: ICD10 A22.0 Cutaneous anthrax
40002 Contributory (secondary) causes of death: ICD10 A26.0 Cutaneous erysipeloid
40002 Contributory (secondary) causes of death: ICD10 A31.1 Cutaneous mycobacterial infection
40002 Contributory (secondary) causes of death: ICD10 A32.0 Cutaneous listeriosis
40002 Contributory (secondary) causes of death: ICD10 A36.3 Cutaneous diphtheria
40002 Contributory (secondary) causes of death: ICD10 A43.1 Cutaneous nocardiosis
40002 Contributory (secondary) causes of death: ICD10 A46 Erysipelas
40002 Contributory (secondary) causes of death: ICD10 A51.3 Secondary syphilis of skin and mucous membranes
40002 Contributory (secondary) causes of death: ICD10 B00.0 Eczema herpeticum
40002 Contributory (secondary) causes of death: ICD10 B00.1 Herpesviral vesicular dermatitis
40002 Contributory (secondary) causes of death: ICD10 B07 Viral warts
40002 Contributory (secondary) causes of death: ICD10 B08 Other viral infections characterized by skin and mucous membrane lesions, not elsewhere classified
40002 Contributory (secondary) causes of death: ICD10 B09 Unspecified viral infection characterized by skin and mucous membrane lesions
40002 Contributory (secondary) causes of death: ICD10 B35 Dermatophytosis
40002 Contributory (secondary) causes of death: ICD10 B36 Other superficial mycoses
40002 Contributory (secondary) causes of death: ICD10 B37.2 Candidiasis of skin and nail
40002 Contributory (secondary) causes of death: ICD10 B38.3 Cutaneous coccidioidomycosis
40002 Contributory (secondary) causes of death: ICD10 B40.3 Cutaneous blastomycosis
40002 Contributory (secondary) causes of death: ICD10 B42.1 Lymphocutaneous sporotrichosis
40002 Contributory (secondary) causes of death: ICD10 B43.0 Cutaneous chromomycosis
40002 Contributory (secondary) causes of death: ICD10 B43.2 Subcutaneous phaeomycotic abscess and cyst
40002 Contributory (secondary) causes of death: ICD10 B45.2 Cutaneous cryptococcosis
40002 Contributory (secondary) causes of death: ICD10 B46.3 Cutaneous mucormycosis
40002 Contributory (secondary) causes of death: ICD10 B55.1 Cutaneous leishmaniasis
40002 Contributory (secondary) causes of death: ICD10 B78.1 Cutaneous strongyloidiasis
40002 Contributory (secondary) causes of death: ICD10 B85 Pediculosis and phthiriasis
40002 Contributory (secondary) causes of death: ICD10 B86 Scabies
40002 Contributory (secondary) causes of death: ICD10 B87.0 Cutaneous myiasis
40002 Contributory (secondary) causes of death: ICD10 B87.1 Wound myiasis
40002 Contributory (secondary) causes of death: ICD10 B88 Other infestations
40002 Contributory (secondary) causes of death: ICD10 L00 Staphylococcal scalded skin syndrome
40002 Contributory (secondary) causes of death: ICD10 L01 Impetigo
40002 Contributory (secondary) causes of death: ICD10 L02 Cutaneous abscess, furuncle and carbuncle
40002 Contributory (secondary) causes of death: ICD10 L03 Cellulitis
40002 Contributory (secondary) causes of death: ICD10 L05.0 Pilonidal cyst with abscess
40002 Contributory (secondary) causes of death: ICD10 L08 Other local infections of skin and subcutaneous tissue
40002 Contributory (secondary) causes of death: ICD10 L30.3 Infective dermatitis
40002 Contributory (secondary) causes of death: ICD10 P38 Omphalitis of newborn with or without mild haemorrhage
40002 Contributory (secondary) causes of death: ICD10 P39.4 Neonatal skin infection