Lupus erythematosus (local and systemic)

Metadata

Name	Lupus erythematosus (local and systemic) (SLE)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	19a755ad-b706-45f2-affe-15b8a7003325
Definition	A long-term condition causing inflammation to the joints, skin and other organs.

Ontologies

Disease Ontology (DOID)	DOID_8857
GWAS Catalogue	EFO_0003834
MeSH	D008180
SNOMED-CT	200936003
FinnGen	L12_LUPUS

Key Summary Statistics

Cases from any source

Total	1338
Female (%)	1109 (83%)
Male (%)	229 (17%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	38.19 (34.04,42.34)
Male	7.42 (5.42,9.42)

Incidence stratified by sex

Female	1.16 (0.88,1.44)
Male	0.42 (0.24,0.61)

Incidence stratified by age

Ages 40-44	0.81 (0.25,1.36)
Ages 45-49	0.67 (0.23,1.11)
Ages 50-54	0.51 (0.16,0.86)
Ages 55-59	0.52 (0.2,0.84)
Ages 60-64	0.85 (0.49,1.2)
Ages 65-69	1.46 (0.93,1.99)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	21 (17,25)	23 (20,27)	26 (22,29)
CALIBER	21 (20,23)	26 (25,28)	28 (27,30)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	15(8,27)	14(8,21)	21(15,28)
Low	17(9,28)	19(13,28)	21(15,28)
Medium	13(7,24)	26(19,36)	29(22,38)
High	20(12,32)	24(17,33)	30(22,39)
Most deprived	34(24,46)	31(23,42)	28(21,38)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	22(17,27)	22(18,26)	25(22,29)
Scotland	16(7,31)	29(19,42)	30(21,42)
Wales	13(4,34)	24(13,41)	24(14,38)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1381	systemic lupus erythematosis/sle
41202	Diagnoses - main ICD10	L93	Lupus erythematosus
41202	Diagnoses - main ICD10	M32	Systemic lupus erythematosus
41204	Diagnoses - secondary ICD10	L93	Lupus erythematosus
41204	Diagnoses - secondary ICD10	M32	Systemic lupus erythematosus
40001	Underlying (primary) cause of death: ICD10	L93	Lupus erythematosus
40001	Underlying (primary) cause of death: ICD10	M32	Systemic lupus erythematosus
40002	Contributory (secondary) causes of death: ICD10	L93	Lupus erythematosus
40002	Contributory (secondary) causes of death: ICD10	M32	Systemic lupus erythematosus
42040	GP clinical event records	F371000	Polyneuropathy in disseminated lupus erythematosus
42040	GP clinical event records	F396100	Myopathy due to disseminated lupus erythematosus
42040	GP clinical event records	F4D3300	Eyelid discoid lupus erythematosus
42040	GP clinical event records	H57y400	Lung disease with systemic lupus erythematosus
42040	GP clinical event records	K01x400	Nephrotic syndrome in systemic lupus erythematosus
42040	GP clinical event records	K01x411	Lupus nephritis
42040	GP clinical event records	K0B4000	Renal tubulo-interstitial disorder in SLE
42040	GP clinical event records	M154000	Lupus erythematosus chronicus
42040	GP clinical event records	M154100	Discoid lupus erythematosus
42040	GP clinical event records	M154200	Lupus erythematosus migrans
42040	GP clinical event records	M154300	Lupus erythematosus nodularis
42040	GP clinical event records	M154400	Lupus erythematosus profundus
42040	GP clinical event records	M154500	Lupus erythematosus tumidus
42040	GP clinical event records	M154600	Lupus erythematosus unguium mutilans
42040	GP clinical event records	M154700	Subacute cutaneous lupus erythematosus
42040	GP clinical event records	M154.00	Lupus erythematosus
42040	GP clinical event records	M154z00	Lupus erythematosus NOS
42040	GP clinical event records	Myu7800	[X]Other local lupus erythematosus
42040	GP clinical event records	N000000	Disseminated lupus erythematosus
42040	GP clinical event records	N000100	Libman-Sacks disease
42040	GP clinical event records	N000200	Drug-induced systemic lupus erythematosus
42040	GP clinical event records	N000300	Systemic lupus erythematosus with organ or sys involv
42040	GP clinical event records	N000400	Systemic lupus erythematosus with pericarditis
42040	GP clinical event records	N000600	Cerebral lupus
42040	GP clinical event records	N000.00	Systemic lupus erythematosus
42040	GP clinical event records	N000z00	Systemic lupus erythematosus NOS
42040	GP clinical event records	Nyu4300	[X]Other forms of systemic lupus erythematosus
42040	GP clinical event records	ZRq8.00	Systemic lupus activity measure
42040	GP clinical event records	ZRq8.11	SLAM - Systemic lupus activity measure
42040	GP clinical event records	ZRq9.00	Systemic lupus erythematosus disease activity index
42040	GP clinical event records	ZRq9.11	SLEDAI-Sys lup ery dis act ind
42040	GP clinical event records	XaC1J	Systemic lupus erythematosus with pericarditis
42040	GP clinical event records	XaBE1	Renal tubulo-interstitial disorder in systemic lupus erythematosus
42040	GP clinical event records	X704h	Subacute cutaneous lupus erythematosus
42040	GP clinical event records	X00Dx	Cerebral lupus