| Name |
Sleep apnoea (sleep_apnoea) |
| Category |
Respiratory |
| Sex |
|
| Adult |
Yes |
| UUID |
63b81fce-5b11-4e7c-8bff-6958864ce399 |
| Definition |
A disorder characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
11568 |
| Female (%) |
3486 (30%) |
| Male (%) |
8082 (70%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
44.2 (39.74,48.67) |
| Male |
163.51 (154.21,172.81) |
Incidence stratified by sex
| Female |
7.94 (7.21,8.67) |
| Male |
20.47 (19.17,21.77) |
Incidence stratified by age
| Ages 40-44 |
11.87 (9.72,14.02) |
| Ages 45-49 |
14.25 (12.22,16.27) |
| Ages 50-54 |
15.08 (13.16,17.01) |
| Ages 55-59 |
14.74 (13.01,16.47) |
| Ages 60-64 |
13.67 (12.24,15.1) |
| Ages 65-69 |
11.61 (10.1,13.12) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
153 (141,166) |
203 (192,215) |
199 (190,209) |
| CALIBER |
122 (119,124) |
178 (174,182) |
185 (181,190) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
74(55,98) |
154(133,178) |
156(139,175) |
| Low |
125(100,155) |
164(141,189) |
172(153,191) |
| Medium |
148(121,179) |
177(154,203) |
195(175,217) |
| High |
158(132,187) |
216(191,244) |
226(204,251) |
| Most deprived |
227(198,258) |
296(267,327) |
261(236,288) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
163(149,177) |
211(199,225) |
205(194,216) |
| Scotland |
108(80,142) |
174(146,204) |
174(149,202) |
| Wales |
122(85,170) |
175(140,216) |
179(148,214) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153513, Events=116
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.85 (1.14, 2.99) |
0.0128 |
| BMI |
obese |
1.9 (1.12, 3.22) |
0.0174 |
| BMI |
underweight |
0 (0, Inf) |
0.993 |
| smoking |
previous |
0.82 (0.53, 1.27) |
0.367 |
| smoking |
current |
1.79 (1.09, 2.95) |
0.0215 |
| hypertension |
yes |
1.55 (1.01, 2.37) |
0.0432 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1123 |
sleep apnoea |
| 41202 |
Diagnoses - main ICD10 |
G47.3 |
Sleep apnoea |
| 41204 |
Diagnoses - secondary ICD10 |
G47.3 |
Sleep apnoea |
| 40001 |
Underlying (primary) cause of death: ICD10 |
G47.3 |
Sleep apnoea |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
G47.3 |
Sleep apnoea |
| 42040 |
GP clinical event records |
Fy03.00 |
Sleep apnoea |
| 42040 |
GP clinical event records |
Fy03.11 |
Obstructive sleep apnoea |
| 42040 |
GP clinical event records |
H5B0.00 |
Obstructive sleep apnoea |
| 42040 |
GP clinical event records |
H5B..00 |
Sleep apnoea |
| 42040 |
GP clinical event records |
R005100 |
[D]Insomnia with sleep apnoea |
| 42040 |
GP clinical event records |
R005300 |
[D]Hypersomnia with sleep apnoea |
| 42040 |
GP clinical event records |
R005311 |
[D]Sleep apnoea syndrome |
| 42040 |
GP clinical event records |
R005312 |
[D]Syndrome sleep apnoea |
| 42040 |
GP clinical event records |
XE2nU |
[D]Hypersomnia with sleep apnoea |
| 42040 |
GP clinical event records |
X0083 |
Sleep apnoea |
| 42040 |
GP clinical event records |
X0084 |
Obstructive sleep apnoea |
| 42040 |
GP clinical event records |
X0083 |
Sleep apnoea |