Metadata
| Name | Spinal stenosis (spinal_stenosis) |
| Category | Musculoskeletal |
| Sex | |
| Adult | Yes |
| UUID | 10ae4664-c0f3-4491-a171-713bb3dc4330 |
| Definition | Narrowing of the spinal canal. |
Ontologies
| Disease Ontology (DOID) | DOID_6725 |
| GWAS Catalogue | EFO_0007490 |
| MeSH | D013130 |
| SNOMED-CT | 76107001 |
| FinnGen | M13_SPINSTENOSIS |
Key Summary Statistics
Cases from any source
| Total | 10203 |
| Female (%) | 5427 (53%) |
| Male (%) | 4776 (47%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 41.26 (36.94,45.57) |
| Male | 52.92 (47.6,58.24) |
Incidence stratified by sex
| Female | 11.96 (11.06,12.86) |
| Male | 13.22 (12.18,14.26) |
Incidence stratified by age
| Ages 40-44 | 3.73 (2.53,4.93) |
| Ages 45-49 | 4.54 (3.4,5.67) |
| Ages 50-54 | 7.05 (5.74,8.36) |
| Ages 55-59 | 11.77 (10.24,13.31) |
| Ages 60-64 | 15.68 (14.15,17.21) |
| Ages 65-69 | 23.48 (21.34,25.62) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 44 (38,51) | 84 (77,91) | 176 (167,185) |
| CALIBER | 38 (36,39) | 83 (80,85) | 164 (160,168) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 31(20,47) | 75(61,92) | 155(138,173) |
| Low | 46(31,65) | 76(62,93) | 173(155,192) |
| Medium | 51(36,70) | 73(59,89) | 184(165,205) |
| High | 41(29,57) | 79(64,95) | 171(152,192) |
| Most deprived | 50(38,66) | 117(99,137) | 200(178,223) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 50(42,58) | 91(83,100) | 184(174,194) |
| Scotland | 12(4,26) | 49(36,67) | 134(112,157) |
| Wales | 34(16,63) | 70(49,97) | 153(126,186) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153824, Events=116
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.57 (0.36, 0.9) | 0.0161 |
| BMI | obese | 1.07 (0.69, 1.66) | 0.75 |
| BMI | underweight | 0 (0, Inf) | 0.992 |
| smoking | previous | 0.88 (0.59, 1.31) | 0.524 |
| smoking | current | 0.55 (0.24, 1.26) | 0.159 |
| hypertension | yes | 1.81 (1.22, 2.71) | 0.00355 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1536 | spinal stenosis |
| 41202 | Diagnoses - main ICD10 | M48.0 | Spinal stenosis |
| 41204 | Diagnoses - secondary ICD10 | M48.0 | Spinal stenosis |
| 40001 | Underlying (primary) cause of death: ICD10 | M48.0 | Spinal stenosis |
| 40002 | Contributory (secondary) causes of death: ICD10 | M48.0 | Spinal stenosis |
| 42040 | GP clinical event records | N130000 | Idiopathic cervical spinal stenosis |
| 42040 | GP clinical event records | N130100 | Degenerative cervical spinal stenosis |
| 42040 | GP clinical event records | N130300 | Cervical spinal stenosis secondary to other disease |
| 42040 | GP clinical event records | N130.00 | Cervical spinal stenosis |
| 42040 | GP clinical event records | N140000 | Spinal stenosis of unspecified region |
| 42040 | GP clinical event records | N140100 | Thoracic spinal stenosis |
| 42040 | GP clinical event records | N140200 | Lumbar spinal stenosis |
| 42040 | GP clinical event records | N140300 | Idiopathic thoracic spinal stenosis |
| 42040 | GP clinical event records | N140400 | Degenerative thoracic spinal stenosis |
| 42040 | GP clinical event records | N140600 | Thoracic spinal stenosis secondary to other disease |
| 42040 | GP clinical event records | N140700 | Idiopathic lumbar spinal stenosis |
| 42040 | GP clinical event records | N140800 | Degenerative lumbar spinal stenosis |
| 42040 | GP clinical event records | N140900 | Iatrogenic lumbar spinal stenosis |
| 42040 | GP clinical event records | N140A00 | Lumbar spinal stenosis secondary to other disease |
| 42040 | GP clinical event records | N140.00 | Spinal stenosis, excluding cervical region |
| 42040 | GP clinical event records | N140.11 | Spinal stenosis |
| 42040 | GP clinical event records | N140z00 | Spinal stenosis NOS |
| 42040 | GP clinical event records | Zw04300 | [Q] Central spinal stenosis |
| 42040 | GP clinical event records | Zw04400 | [Q] Lateral spinal stenosis |
| 42040 | GP clinical event records | Zw04500 | [Q] Central and lateral spinal stenosis |
| 42040 | GP clinical event records | XE1F9 | Spinal stenosis, excluding cervical region |