| Name |
Splenomegaly (splenomegaly) |
| Category |
Haematological or immunological |
| Sex |
|
| Adult |
Yes |
| UUID |
d9a08ab1-bc4c-4dc1-96ac-9d22212c1d42 |
| Definition |
Enlargement of the spleen. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1232 |
| Female (%) |
411 (33%) |
| Male (%) |
821 (67%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
3.65 (2.37,4.94) |
| Male |
10.08 (7.75,12.41) |
Incidence stratified by sex
| Female |
0.69 (0.47,0.9) |
| Male |
1.9 (1.5,2.29) |
Incidence stratified by age
| Ages 40-44 |
0.9 (0.31,1.5) |
| Ages 45-49 |
0.44 (0.09,0.8) |
| Ages 50-54 |
0.82 (0.38,1.27) |
| Ages 55-59 |
1.04 (0.58,1.5) |
| Ages 60-64 |
1.73 (1.22,2.23) |
| Ages 65-69 |
1.81 (1.22,2.4) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
8 (5,11) |
15 (12,19) |
16 (13,19) |
| CALIBER |
13 (12,14) |
17 (16,19) |
23 (22,25) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
7(2,17) |
9(4,16) |
10(6,16) |
| Low |
9(3,19) |
7(3,14) |
15(10,21) |
| Medium |
4(1,12) |
15(9,23) |
18(12,26) |
| High |
11(5,21) |
18(11,27) |
20(14,28) |
| Most deprived |
7(3,14) |
26(18,37) |
18(12,26) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
8(6,12) |
15(12,19) |
15(13,19) |
| Scotland |
5(1,17) |
18(10,30) |
15(8,25) |
| Wales |
4(0,21) |
16(7,31) |
24(13,38) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153969, Events=129
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.18 (0.74, 1.86) |
0.489 |
| BMI |
obese |
1.91 (1.2, 3.06) |
0.00685 |
| BMI |
underweight |
0 (0, Inf) |
0.995 |
| smoking |
previous |
1.29 (0.88, 1.87) |
0.189 |
| smoking |
current |
1.41 (0.81, 2.45) |
0.23 |
| hypertension |
yes |
1.93 (1.34, 2.77) |
0.000403 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
D73.1 |
Hypersplenism |
| 41202 |
Diagnoses - main ICD10 |
D73.2 |
Chronic congestive splenomegaly |
| 41202 |
Diagnoses - main ICD10 |
R16.1 |
Splenomegaly, not elsewhere classified |
| 41202 |
Diagnoses - main ICD10 |
R16.2 |
Hepatomegaly with splenomegaly, not elsewhere classified |
| 41204 |
Diagnoses - secondary ICD10 |
D73.1 |
Hypersplenism |
| 41204 |
Diagnoses - secondary ICD10 |
D73.2 |
Chronic congestive splenomegaly |
| 41204 |
Diagnoses - secondary ICD10 |
R16.1 |
Splenomegaly, not elsewhere classified |
| 41204 |
Diagnoses - secondary ICD10 |
R16.2 |
Hepatomegaly with splenomegaly, not elsewhere classified |
| 40001 |
Underlying (primary) cause of death: ICD10 |
D73.1 |
Hypersplenism |
| 40001 |
Underlying (primary) cause of death: ICD10 |
D73.2 |
Chronic congestive splenomegaly |
| 40001 |
Underlying (primary) cause of death: ICD10 |
R16.1 |
Splenomegaly, not elsewhere classified |
| 40001 |
Underlying (primary) cause of death: ICD10 |
R16.2 |
Hepatomegaly with splenomegaly, not elsewhere classified |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
D73.1 |
Hypersplenism |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
D73.2 |
Chronic congestive splenomegaly |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
R16.1 |
Splenomegaly, not elsewhere classified |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
R16.2 |
Hepatomegaly with splenomegaly, not elsewhere classified |
| 42040 |
GP clinical event records |
D414.00 |
Hypersplenism |
| 42040 |
GP clinical event records |
D415100 |
Chronic congestive splenamegaly |
| 42040 |
GP clinical event records |
J61y200 |
Hepatosplenomegaly |
| 42040 |
GP clinical event records |
PK03.00 |
Congenital splenomegaly |
| 42040 |
GP clinical event records |
PK03.11 |
Hyperplasia of spleen |
| 42040 |
GP clinical event records |
R092000 |
[D]Spleen enlargement |
| 42040 |
GP clinical event records |
R092.00 |
[D]Splenomegaly |
| 42040 |
GP clinical event records |
R092z00 |
[D]Splenomegaly NOS |
| 42040 |
GP clinical event records |
XE2R3 |
Congenital splenomegaly |