| Name |
Spondylolisthesis (spondylolisthesis) |
| Category |
Musculoskeletal |
| Sex |
|
| Adult |
Yes |
| UUID |
d8dfc0ab-653e-4820-9843-aa35bc9e9261 |
| Definition |
Spondylolisthesis is where one of the bones in your spine, known as a vertebra, slips out of position. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
4406 |
| Female (%) |
2850 (65%) |
| Male (%) |
1556 (35%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
47.03 (42.43,51.64) |
| Male |
39.34 (34.75,43.93) |
Incidence stratified by sex
| Female |
5.37 (4.77,5.98) |
| Male |
3.02 (2.53,3.52) |
Incidence stratified by age
| Ages 40-44 |
0.81 (0.25,1.36) |
| Ages 45-49 |
1.94 (1.19,2.68) |
| Ages 50-54 |
3.69 (2.74,4.63) |
| Ages 55-59 |
3.86 (2.98,4.74) |
| Ages 60-64 |
5.56 (4.66,6.47) |
| Ages 65-69 |
6.93 (5.77,8.08) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
28 (23,34) |
44 (39,50) |
72 (67,78) |
| CALIBER |
25 (24,26) |
44 (42,46) |
74 (71,77) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
25(15,39) |
42(32,55) |
61(51,73) |
| Low |
20(11,33) |
46(35,60) |
72(60,84) |
| Medium |
37(24,53) |
36(26,48) |
73(61,86) |
| High |
24(15,37) |
38(28,50) |
78(65,92) |
| Most deprived |
34(23,47) |
59(47,74) |
78(65,93) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
29(24,36) |
49(43,55) |
77(71,84) |
| Scotland |
19(9,36) |
23(14,36) |
42(31,56) |
| Wales |
31(14,58) |
35(21,56) |
62(45,83) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153824, Events=116
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.57 (0.36, 0.9) |
0.0161 |
| BMI |
obese |
1.07 (0.69, 1.66) |
0.75 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
0.88 (0.59, 1.31) |
0.524 |
| smoking |
current |
0.55 (0.24, 1.26) |
0.159 |
| hypertension |
yes |
1.81 (1.22, 2.71) |
0.00355 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20004 |
Operation code |
1590 |
spinal fusion |
| 41202 |
Diagnoses - main ICD10 |
M43.1 |
Spondylolisthesis |
| 41204 |
Diagnoses - secondary ICD10 |
M43.1 |
Spondylolisthesis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
M43.1 |
Spondylolisthesis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
M43.1 |
Spondylolisthesis |
| 42040 |
GP clinical event records |
7J34112 |
Buck fusion of lumbar spine for spondylolisthesis |
| 42040 |
GP clinical event records |
7J48500 |
Spondylolisthesis operation |
| 42040 |
GP clinical event records |
7J48511 |
Gill excision of spondylolisthesis |
| 42040 |
GP clinical event records |
7J48K00 |
Reduction of spondylolisthesis and fusion |
| 42040 |
GP clinical event records |
7J48L00 |
Fusion spondylolisthesis in situ |
| 42040 |
GP clinical event records |
N384000 |
Dysplastic spondylolisthesis |
| 42040 |
GP clinical event records |
N384100 |
Isthmic spondylolisthesis |
| 42040 |
GP clinical event records |
N384200 |
Degenerative spondylolisthesis |
| 42040 |
GP clinical event records |
N384300 |
Pedicular spondylolisthesis |
| 42040 |
GP clinical event records |
N384.00 |
Acquired spondylolisthesis |
| 42040 |
GP clinical event records |
Zw04600 |
[Q] Spondylolisthesis grade 1 |
| 42040 |
GP clinical event records |
Zw04700 |
[Q] Spondylolisthesis grade 2 |
| 42040 |
GP clinical event records |
Zw04800 |
[Q] Spondylolisthesis grade 3 |
| 42040 |
GP clinical event records |
Zw04900 |
[Q] Spondylolisthesis grade 4 |
| 42040 |
GP clinical event records |
XE0It |
Spondylolisthesis operation |
| 42040 |
GP clinical event records |
XE2Q0 |
Primary posterior fusion of joint of lumbar spine NEC |