Spondylosis

Metadata

Name	Spondylosis (spondylosis)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	f3c109fc-d94f-46fe-a3b3-e818f9ba505f
Definition	Spondylosis is an umbrella term used to describe pain from degenerative conditions of the spine.

Ontologies

Disease Ontology (DOID)	DOID_2247
GWAS Catalogue	MONDO_0002253
MeSH	D055009
SNOMED-CT	8847002
FinnGen	M13_SPONDYLOSIS

Key Summary Statistics

Cases from any source

Total	33839
Female (%)	20217 (60%)
Male (%)	13622 (40%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	600.58 (584.6,616.57)
Male	503.56 (487.52,519.59)

Incidence stratified by sex

Female	39.86 (38.16,41.57)
Male	32.55 (30.88,34.23)

Incidence stratified by age

Ages 40-44	16.79 (14.22,19.36)
Ages 45-49	24.53 (21.85,27.21)
Ages 50-54	28.87 (26.16,31.58)
Ages 55-59	34.31 (31.6,37.02)
Ages 60-64	44.63 (41.94,47.32)
Ages 65-69	54.08 (50.66,57.51)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	290 (274,307)	568 (550,587)	1033 (1012,1054)
CALIBER	230 (226,234)	546 (539,553)	1018 (1008,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	216(184,253)	497(459,536)	957(914,1001)
Low	251(215,291)	477(440,516)	990(947,1035)
Medium	283(247,323)	563(523,605)	977(933,1022)
High	286(252,323)	573(533,615)	1043(996,1092)
Most deprived	376(339,415)	726(681,773)	1234(1180,1290)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	308(290,327)	586(565,607)	1048(1025,1072)
Scotland	174(140,215)	431(389,477)	907(851,965)
Wales	281(224,347)	625(559,696)	1063(988,1143)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153824, Events=116

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.57 (0.36, 0.9)	0.0161
BMI	obese	1.07 (0.69, 1.66)	0.75
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	0.88 (0.59, 1.31)	0.524
smoking	current	0.55 (0.24, 1.26)	0.159
hypertension	yes	1.81 (1.22, 2.71)	0.00355

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1478	cervical spondylosis
41202	Diagnoses - main ICD10	M47	Spondylosis
41202	Diagnoses - main ICD10	M47.1	Other spondylosis with myelopathy
41202	Diagnoses - main ICD10	M47.2	Other spondylosis with radiculopathy
41202	Diagnoses - main ICD10	M47.8	Other spondylosis
41202	Diagnoses - main ICD10	M47.9	Spondylosis, unspecified
41204	Diagnoses - secondary ICD10	M47	Spondylosis
41204	Diagnoses - secondary ICD10	M47.1	Other spondylosis with myelopathy
41204	Diagnoses - secondary ICD10	M47.2	Other spondylosis with radiculopathy
41204	Diagnoses - secondary ICD10	M47.8	Other spondylosis
41204	Diagnoses - secondary ICD10	M47.9	Spondylosis, unspecified
40001	Underlying (primary) cause of death: ICD10	M47.1	Other spondylosis with myelopathy
40001	Underlying (primary) cause of death: ICD10	M47.2	Other spondylosis with radiculopathy
40001	Underlying (primary) cause of death: ICD10	M47.8	Other spondylosis
40001	Underlying (primary) cause of death: ICD10	M47.9	Spondylosis, unspecified
40002	Contributory (secondary) causes of death: ICD10	M47.1	Other spondylosis with myelopathy
40002	Contributory (secondary) causes of death: ICD10	M47.2	Other spondylosis with radiculopathy
40002	Contributory (secondary) causes of death: ICD10	M47.8	Other spondylosis
40002	Contributory (secondary) causes of death: ICD10	M47.9	Spondylosis, unspecified
42040	GP clinical event records	F163200	Myelopathy due to spondylosis
42040	GP clinical event records	F337200	Nerve root and plexus compressions in spondylosis
42040	GP clinical event records	N110000	Single-level cervical spondylosis without myelopathy
42040	GP clinical event records	N110100	Two-level cervical spondylosis without myelopathy
42040	GP clinical event records	N110200	Multiple-level cervical spondylosis without myelopathy
42040	GP clinical event records	N110.00	Cervical spondylosis without myelopathy
42040	GP clinical event records	N110.11	Cervical spondylosis
42040	GP clinical event records	N110.12	Osteoarthritis cervical spine
42040	GP clinical event records	N111000	Single-level cervical spondylosis with myelopathy
42040	GP clinical event records	N111100	Two-level cervical spondylosis with myelopathy
42040	GP clinical event records	N111200	Multiple-level cervical spondylosis with myelopathy
42040	GP clinical event records	N111.00	Cervical spondylosis with myelopathy
42040	GP clinical event records	N112000	Single-level thoracic spondylosis without myelopathy
42040	GP clinical event records	N112100	Two-level thoracic spondylosis without myelopathy
42040	GP clinical event records	N112200	Multiple-level thoracic spondylosis without myelopathy
42040	GP clinical event records	N112300	Dorsal spondylosis without myelopathy
42040	GP clinical event records	N112.00	Thoracic spondylosis without myelopathy
42040	GP clinical event records	N112.11	Thoracic spondylosis
42040	GP clinical event records	N113000	Single-level thoracic spondylosis with myelopathy
42040	GP clinical event records	N113200	Multiple-level thoracic spondylosis with myelopathy
42040	GP clinical event records	N113.00	Thoracic spondylosis with myelopathy
42040	GP clinical event records	N114000	Single-level lumbosacral spondylosis without myelopathy
42040	GP clinical event records	N114100	Two-level lumbosacral spondylosis without myelopathy
42040	GP clinical event records	N114200	Multiple-level lumbosacral spondylosis without myelopathy
42040	GP clinical event records	N114.00	Lumbosacral spondylosis without myelopathy
42040	GP clinical event records	N114.11	Degeneration of lumbar spine
42040	GP clinical event records	N114.12	Lumbar spondylosis
42040	GP clinical event records	N115000	Single-level lumbosacral spondylosis with myelopathy
42040	GP clinical event records	N115100	Two-level lumbosacral spondylosis with myelopathy
42040	GP clinical event records	N115200	Multiple-level lumbosacral spondylosis with myelopathy
42040	GP clinical event records	N115.00	Lumbosacral spondylosis with myelopathy
42040	GP clinical event records	N119000	Single-level cervical spondylosis with radiculopathy
42040	GP clinical event records	N119100	Two-level cervical spondylosis with radiculopathy
42040	GP clinical event records	N119200	Multiple-level cervical spondylosis with radiculopathy
42040	GP clinical event records	N119.00	Cervical spondylosis with radiculopathy
42040	GP clinical event records	N11A.00	Cervical spondylosis with vascular compression
42040	GP clinical event records	N11B000	Single-level thoracic spondylosis with radiculopathy
42040	GP clinical event records	N11B100	Two-level thoracic spondylosis with radiculopathy
42040	GP clinical event records	N11B200	Multiple-level thoracic spondylosis with radiculopathy
42040	GP clinical event records	N11B.00	Thoracic spondylosis with radiculopathy
42040	GP clinical event records	N11C000	Single-level lumbosacral spondylosis with radiculopathy
42040	GP clinical event records	N11C100	Two-level lumbosacral spondylosis with radiculopathy
42040	GP clinical event records	N11C200	Multiple-level lumbosacral spondylosis with radiculopathy
42040	GP clinical event records	N11C.00	Lumbosacral spondylosis with radiculopathy
42040	GP clinical event records	N11D000	Osteoarthritis of cervical spine
42040	GP clinical event records	N11D100	Osteoarthritis of thoracic spine
42040	GP clinical event records	N11D200	Osteoarthritis of lumbar spine
42040	GP clinical event records	N11D300	Osteoarthritis of spine NOS
42040	GP clinical event records	N11D.00	Osteoarthritis of spine
42040	GP clinical event records	N11E.00	Cervical spondylosis
42040	GP clinical event records	N11..00	Spondylosis and allied disorders
42040	GP clinical event records	N11..11	Arthritis of spine
42040	GP clinical event records	N11..12	Osteoarthritis of spine
42040	GP clinical event records	N11z000	Spondylosis without myelopathy, NOS
42040	GP clinical event records	N11z100	Spondylosis with myelopathy, NOS
42040	GP clinical event records	N11z.00	Spondylosis NOS
42040	GP clinical event records	N11z.11	Osteoarthritis spine
42040	GP clinical event records	N11zz00	Spondylosis NOS
42040	GP clinical event records	Nyu6300	[X]Other spondylosis with radiculopathy
42040	GP clinical event records	Nyu6400	[X]Other spondylosis
42040	GP clinical event records	XE1Ey	Spondylosis NOS
42040	GP clinical event records	XE1Ey	Spondylosis NOS
42040	GP clinical event records	XE1Ev	Cervical spondylosis with myelopathy
42040	GP clinical event records	XE1Ex	Lumbosacral spondylosis without myelopathy
42040	GP clinical event records	XE1Eu	Cervical spondylosis without myelopathy
42040	GP clinical event records	XE1Ew	Thoracic spondylosis without myelopathy
42040	GP clinical event records	X703j	Cervical spondylosis
42040	GP clinical event records	XE1Et	Spondylosis and allied disorders