Metadata

Name Stable angina (stable_angina)
Category Cardiovascular
Sex
Adult Yes
UUID 8593d86e-1be8-40bf-8b8a-438f6667eb90
Definition Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity.

Ontologies

GWAS Catalogue EFO_0003913
MeSH D060050
SNOMED-CT 233819005
FinnGen I9_ANGINA

Key Summary Statistics

Cases from any source

Total 32804
Female (%) 11573 (35%)
Male (%) 21231 (65%)

Year first recorded

stable_angina year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced stable_angina cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of stable_angina

Baseline prevalence stratified by sex

Female 225.26 (215.28,235.25)
Male 576.91 (559.81,594.01)

Incidence stratified by sex

Female 21.69 (20.47,22.92)
Male 52.42 (50.28,54.56)

Incidence stratified by age

Ages 40-44 7.07 (5.41,8.72)
Ages 45-49 13.29 (11.33,15.25)
Ages 50-54 23.0 (20.6,25.39)
Ages 55-59 33.74 (31.09,36.39)
Ages 60-64 45.48 (42.8,48.16)
Ages 65-69 65.86 (62.1,69.62)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB stable_angina prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 126 (116,138) 396 (380,412) 937 (917,957)
CALIBER 122 (119,125) 403 (397,409) 913 (903,923)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 83(63,107) 285(255,316) 764(725,805)
Low 101(78,128) 320(289,354) 821(781,863)
Medium 90(70,115) 358(325,393) 887(844,931)
High 121(98,146) 391(357,427) 982(935,1031)
Most deprived 207(180,236) 612(571,656) 1305(1249,1363)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 129(117,142) 397(379,415) 933(911,956)
Scotland 128(98,165) 393(352,438) 976(917,1039)
Wales 100(66,145) 391(337,450) 914(843,989)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153979, Events=141

Factor Level Hazard Ratio P value
BMI overweight 1.41 (0.92, 2.17) 0.113
BMI obese 1.52 (0.95, 2.43) 0.0832
BMI underweight 0 (0, Inf) 0.992
smoking previous 0.89 (0.63, 1.27) 0.531
smoking current 0.83 (0.44, 1.56) 0.561
hypertension yes 1.5 (1.06, 2.12) 0.0207

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
41202 Diagnoses - main ICD10 I20.1 Angina pectoris with documented spasm
41202 Diagnoses - main ICD10 I20.8 Other forms of angina pectoris
41202 Diagnoses - main ICD10 I20.9 Angina pectoris, unspecified
41204 Diagnoses - secondary ICD10 I20.1 Angina pectoris with documented spasm
41204 Diagnoses - secondary ICD10 I20.8 Other forms of angina pectoris
41204 Diagnoses - secondary ICD10 I20.9 Angina pectoris, unspecified
40001 Underlying (primary) cause of death: ICD10 I20.1 Angina pectoris with documented spasm
40001 Underlying (primary) cause of death: ICD10 I20.8 Other forms of angina pectoris
40001 Underlying (primary) cause of death: ICD10 I20.9 Angina pectoris, unspecified
40002 Contributory (secondary) causes of death: ICD10 I20.1 Angina pectoris with documented spasm
40002 Contributory (secondary) causes of death: ICD10 I20.8 Other forms of angina pectoris
40002 Contributory (secondary) causes of death: ICD10 I20.9 Angina pectoris, unspecified
42040 GP clinical event records G33z400 Ischaemic chest pain
42040 GP clinical event records 14A5.00 H/O: angina pectoris
42040 GP clinical event records 14AJ.00 H/O: Angina in last year
42040 GP clinical event records 662K.00 Angina control
42040 GP clinical event records 662K000 Angina control - good
42040 GP clinical event records 662K100 Angina control - poor
42040 GP clinical event records 662K200 Angina control - improving
42040 GP clinical event records 662Kz00 Angina control NOS
42040 GP clinical event records 8B27.00 Antianginal therapy
42040 GP clinical event records G33..00 Angina pectoris
42040 GP clinical event records G330.00 Angina decubitus
42040 GP clinical event records G330000 Nocturnal angina
42040 GP clinical event records G330z00 Angina decubitus NOS
42040 GP clinical event records G33z.00 Angina pectoris NOS
42040 GP clinical event records G33z100 Stenocardia
42040 GP clinical event records G33z200 Syncope anginosa
42040 GP clinical event records G33z300 Angina on effort
42040 GP clinical event records G33z500 Post infarct angina
42040 GP clinical event records G33z600 New onset angina
42040 GP clinical event records G33z700 Stable angina
42040 GP clinical event records G33zz00 Angina pectoris NOS
42040 GP clinical event records G34y000 Chronic coronary insufficiency
42040 GP clinical event records Gyu3000 [X]Other forms of angina pectoris
42040 GP clinical event records 7928.11 Percutaneous balloon coronary angioplasty
42040 GP clinical event records 7928000 Percut transluminal balloon angioplasty one coronary artery
42040 GP clinical event records 7928100 Percut translum balloon angioplasty mult coronary arteries
42040 GP clinical event records 7928200 Percut translum balloon angioplasty bypass graft coronary a
42040 GP clinical event records 7928300 Percut translum cutting balloon angioplasty coronary artery
42040 GP clinical event records 7928y00 Transluminal balloon angioplasty of coronary artery OS
42040 GP clinical event records 7928z00 Transluminal balloon angioplasty of coronary artery NOS
42040 GP clinical event records 7929000 Percutaneous transluminal laser coronary angioplasty
42040 GP clinical event records 7929300 Rotary blade coronary angioplasty
42040 GP clinical event records 7929400 Insertion of coronary artery stent
42040 GP clinical event records 7929500 Insertion of drug-eluting coronary artery stent
42040 GP clinical event records 7929600 Percutaneous transluminal atherectomy of coronary artery
42040 GP clinical event records 792B000 Endarterectomy of coronary artery NEC
42040 GP clinical event records 793G.00 Perc translumin balloon angioplasty stenting coronary artery
42040 GP clinical event records 793G000 Perc translum ball angio insert 1-2 drug elut stents cor art
42040 GP clinical event records 793G100 Perc tran ball angio ins 3 or more drug elut stents cor art
42040 GP clinical event records 793G200 Perc translum balloon angioplasty insert 1-2 stents cor art
42040 GP clinical event records 793G300 Percutaneous cor balloon angiop 3 more stents cor art NEC
42040 GP clinical event records 793Gy00 OS perc translumina balloon angioplast stenting coronary art
42040 GP clinical event records 793Gz00 Perc translum balloon angioplasty stenting coronary art NOS
42040 GP clinical event records 7A54000 Percutaneous transluminal angioplasty of artery NEC
42040 GP clinical event records 7A54500 Rotary blade angioplasty
42040 GP clinical event records 7A54800 Percutaneous transluminal atherectomy
42040 GP clinical event records 7A56400 Percutaneous transluminal balloon angioplasty of artery
42040 GP clinical event records 7A6G100 Peroperative angioplasty
42040 GP clinical event records 7A6H300 Prosthetic graft patch angioplasty
42040 GP clinical event records 7A6H400 Percutaneous transluminal angioplasty of vascular graft
42040 GP clinical event records 792..11 Coronary artery bypass graft operations
42040 GP clinical event records 7920 Saphenous vein graft replacement of coronary artery
42040 GP clinical event records 7920.11 Saphenous vein graft bypass of coronary artery
42040 GP clinical event records 7920000 Saphenous vein graft replacement of one coronary artery
42040 GP clinical event records 7920100 Saphenous vein graft replacement of two coronary arteries
42040 GP clinical event records 7920200 Saphenous vein graft replacement of three coronary arteries
42040 GP clinical event records 7920300 Saphenous vein graft replacement of four+ coronary arteries
42040 GP clinical event records 7920y00 Saphenous vein graft replacement of coronary artery OS
42040 GP clinical event records 7920z00 Saphenous vein graft replacement coronary artery NOS
42040 GP clinical event records 7921 Other autograft replacement of coronary artery
42040 GP clinical event records 7921.11 Other autograft bypass of coronary artery
42040 GP clinical event records 7921000 Autograft replacement of one coronary artery NEC
42040 GP clinical event records 7921100 Autograft replacement of two coronary arteries NEC
42040 GP clinical event records 7921200 Autograft replacement of three coronary arteries NEC
42040 GP clinical event records 7921300 Autograft replacement of four of more coronary arteries NEC
42040 GP clinical event records 7921y00 Other autograft replacement of coronary artery OS
42040 GP clinical event records 7921z00 Other autograft replacement of coronary artery NOS
42040 GP clinical event records 7922 Allograft replacement of coronary artery
42040 GP clinical event records 7922.11 Allograft bypass of coronary artery
42040 GP clinical event records 7922000 Allograft replacement of one coronary artery
42040 GP clinical event records 7922100 Allograft replacement of two coronary arteries
42040 GP clinical event records 7922200 Allograft replacement of three coronary arteries
42040 GP clinical event records 7922300 Allograft replacement of four or more coronary arteries
42040 GP clinical event records 7922y00 Other specified allograft replacement of coronary artery
42040 GP clinical event records 7922z00 Allograft replacement of coronary artery NOS
42040 GP clinical event records 7923 Prosthetic replacement of coronary artery
42040 GP clinical event records 7923.11 Prosthetic bypass of coronary artery
42040 GP clinical event records 7923000 Prosthetic replacement of one coronary artery
42040 GP clinical event records 7923100 Prosthetic replacement of two coronary arteries
42040 GP clinical event records 7923200 Prosthetic replacement of three coronary arteries
42040 GP clinical event records 7923300 Prosthetic replacement of four or more coronary arteries
42040 GP clinical event records 7923z00 Prosthetic replacement of coronary artery NOS
42040 GP clinical event records 7925 Connection of mammary artery to coronary artery
42040 GP clinical event records 7925.11 Creation of bypass from mammary artery to coronary artery
42040 GP clinical event records 7925000 Double anastomosis of mammary arteries to coronary arteries
42040 GP clinical event records 7925100 Double implant of mammary arteries into coronary arteries
42040 GP clinical event records 7925300 Single anastomosis of mammary artery to coronary artery NEC
42040 GP clinical event records 7925311 LIMA single anastomosis
42040 GP clinical event records 7925312 RIMA single anastomosis
42040 GP clinical event records 7925400 Single implantation of mammary artery into coronary artery
42040 GP clinical event records 7925y00 Connection of mammary artery to coronary artery OS
42040 GP clinical event records 7925z00 Connection of mammary artery to coronary artery NOS
42040 GP clinical event records 7926 Connection of other thoracic artery to coronary artery
42040 GP clinical event records 7926000 Double anastom thoracic arteries to coronary arteries NEC
42040 GP clinical event records 7926200 Single anastomosis of thoracic artery to coronary artery NEC
42040 GP clinical event records 7926300 Single implantation thoracic artery into coronary artery NEC
42040 GP clinical event records 7926z00 Connection of other thoracic artery to coronary artery NOS
42040 GP clinical event records 7927500 Open angioplasty of coronary artery
42040 GP clinical event records 792C.00 Other replacement of coronary artery
42040 GP clinical event records 792C000 Replacement of coronary arteries using multiple methods
42040 GP clinical event records 792Cy00 Other specified replacement of coronary artery
42040 GP clinical event records 792Cz00 Replacement of coronary artery NOS
42040 GP clinical event records 792D.00 Other bypass of coronary artery
42040 GP clinical event records 792Dy00 Other specified other bypass of coronary artery
42040 GP clinical event records 792Dz00 Other bypass of coronary artery NOS
42040 GP clinical event records SP00300 Mechanical complication of coronary bypass
42040 GP clinical event records SP07600 Coronary artery bypass graft occlusion
42040 GP clinical event records 5543 Coronary arteriograph.abnormal
42040 GP clinical event records 3213100 Exercise ECG abnormal
42040 GP clinical event records 3213111 Positive exercise ECG test
42040 GP clinical event records 33B9500 Exercise tolerance test abnormal
42040 GP clinical event records 322..00 ECG: myocardial ischaemia
42040 GP clinical event records 3222 ECG:shows myocardial ischaemia
42040 GP clinical event records 322Z.00 ECG: myocardial ischaemia NOS
42040 GP clinical event records 32E4.00 ECG: S-T depression
42040 GP clinical event records 32F2.00 ECG: T wave abnormal
42040 GP clinical event records 32F3.00 ECG: T wave flattened
42040 GP clinical event records 32F4.00 ECG: T wave inverted
42040 GP clinical event records 5C11.00 Radionuclide heart study abnormal
42040 GP clinical event records X70Wk Percutaneous transluminal atherectomy
42040 GP clinical event records Ua1eH Ischaemic chest pain
42040 GP clinical event records X00tU Insertion of coronary artery stent
42040 GP clinical event records XaLgU Percutaneous transluminal balloon angioplasty and stenting of coronary artery
42040 GP clinical event records G33z. Angina pectoris NOS
42040 GP clinical event records XaLgV Percutaneous transluminal balloon angioplasty and insertion of 1-2 drug eluting stents into coronary artery
42040 GP clinical event records XE0En Double anastomosis of mammary arteries to coronary arteries
42040 GP clinical event records X200A New onset angina
42040 GP clinical event records XaDyl Percutaneous transluminal angioplasty of vascular graft
42040 GP clinical event records XaEXt Post infarct angina
42040 GP clinical event records XE2Px Single anastomosis of mammary artery to coronary artery NEC
42040 GP clinical event records XaMKE Percutaneous transluminal cutting balloon angioplasty of coronary artery
42040 GP clinical event records XaJi9 Radionuclide heart study abnormal
42040 GP clinical event records XaLga Percutaneous transluminal balloon angioplasty and stenting of coronary artery NOS
42040 GP clinical event records X2008 Stable angina
42040 GP clinical event records XaDyk Prosthetic graft patch angioplasty
42040 GP clinical event records XaLgX Percutaneous transluminal balloon angioplasty and insertion of 1-2 stents into coronary artery
42040 GP clinical event records XaLhc Percutaneous transluminal balloon angioplasty of artery
42040 GP clinical event records XaLgY Percutaneous coronary balloon angioplasty and 3 or more stents into coronary artery NEC
42040 GP clinical event records XaBLr Antianginal therapy
42040 GP clinical event records XaLgZ Other specified percutaneous transluminal balloon angioplasty and stenting of coronary artery
42040 GP clinical event records XaLSD Insertion of drug-eluting coronary artery stent
42040 GP clinical event records XaBL2 H/O: Angina in last year
42040 GP clinical event records XaJIU Coronary artery bypass graft occlusion
42040 GP clinical event records XaLgW Percutaneous transluminal balloon angioplasty and insertion of 3 or more drug eluting stents into coronary artery