Stroke NOS

Metadata

Name	Stroke NOS (Stroke_NOS)
Category	Cardiovascular
Sex
Adult	Yes
UUID	c3bad7c9-ab38-4245-a449-cc103911ce5d
Definition	A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to brain ischemia or intracranial hemorrhages.

Ontologies

Disease Ontology (DOID)	DOID_6713
GWAS Catalogue	EFO_0000712
MeSH	D020521
SNOMED-CT	230690007
FinnGen	C_STROKE

Key Summary Statistics

Cases from any source

Total	8087
Female (%)	3296 (41%)
Male (%)	4791 (59%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	140.39 (132.47,148.31)
Male	248.77 (237.35,260.19)

Incidence stratified by sex

Female	2.57 (2.15,2.99)
Male	4.71 (4.09,5.34)

Incidence stratified by age

Ages 40-44	0.51 (0.06,0.95)
Ages 45-49	0.82 (0.34,1.31)
Ages 50-54	1.98 (1.29,2.68)
Ages 55-59	2.64 (1.91,3.38)
Ages 60-64	4.05 (3.27,4.84)
Ages 65-69	8.48 (7.17,9.78)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	65 (58,74)	145 (136,155)	311 (299,323)
CALIBER	26 (24,27)	70 (67,72)	173 (169,177)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	39(26,57)	91(75,110)	243(221,266)
Low	44(30,63)	120(101,141)	272(249,296)
Medium	48(33,66)	130(110,151)	295(270,321)
High	65(49,84)	139(119,161)	302(276,329)
Most deprived	110(91,133)	242(216,270)	472(438,507)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	61(53,70)	126(116,136)	283(270,295)
Scotland	102(75,135)	236(204,271)	490(448,534)
Wales	54(31,89)	182(147,223)	335(293,381)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=154060, Events=218

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.65, 1.23)	0.488
BMI	obese	1.16 (0.82, 1.63)	0.404
BMI	underweight	0 (0, Inf)	0.989
smoking	previous	1.75 (1.31, 2.35)	0.000182
smoking	current	2.37 (1.58, 3.55)	3.07e-05
hypertension	yes	1 (0.74, 1.36)	0.997

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	G46.3	Brain stem stroke syndrome
41202	Diagnoses - main ICD10	G46.4	Cerebellar stroke syndrome
41202	Diagnoses - main ICD10	G46.5	Pure motor lacunar syndrome
41202	Diagnoses - main ICD10	G46.6	Pure sensory lacunar syndrome
41202	Diagnoses - main ICD10	G46.7	Other lacunar syndromes
41202	Diagnoses - main ICD10	G46.8	Other vascular syndromes of brain in cerebrovascular diseases
41202	Diagnoses - main ICD10	I64	Stroke, not specified as haemorrhage or infarction
41202	Diagnoses - main ICD10	I69.4	Sequelae of stroke, not specified as haemorrhage or infarction
41204	Diagnoses - secondary ICD10	G46.3	Brain stem stroke syndrome
41204	Diagnoses - secondary ICD10	G46.4	Cerebellar stroke syndrome
41204	Diagnoses - secondary ICD10	G46.5	Pure motor lacunar syndrome
41204	Diagnoses - secondary ICD10	G46.6	Pure sensory lacunar syndrome
41204	Diagnoses - secondary ICD10	G46.7	Other lacunar syndromes
41204	Diagnoses - secondary ICD10	G46.8	Other vascular syndromes of brain in cerebrovascular diseases
41204	Diagnoses - secondary ICD10	I64	Stroke, not specified as haemorrhage or infarction
41204	Diagnoses - secondary ICD10	I69.4	Sequelae of stroke, not specified as haemorrhage or infarction
40001	Underlying (primary) cause of death: ICD10	G46.3	Brain stem stroke syndrome
40001	Underlying (primary) cause of death: ICD10	G46.4	Cerebellar stroke syndrome
40001	Underlying (primary) cause of death: ICD10	G46.5	Pure motor lacunar syndrome
40001	Underlying (primary) cause of death: ICD10	G46.6	Pure sensory lacunar syndrome
40001	Underlying (primary) cause of death: ICD10	G46.7	Other lacunar syndromes
40001	Underlying (primary) cause of death: ICD10	G46.8	Other vascular syndromes of brain in cerebrovascular diseases
40001	Underlying (primary) cause of death: ICD10	I64	Stroke, not specified as haemorrhage or infarction
40001	Underlying (primary) cause of death: ICD10	I69.4	Sequelae of stroke, not specified as haemorrhage or infarction
40002	Contributory (secondary) causes of death: ICD10	G46.3	Brain stem stroke syndrome
40002	Contributory (secondary) causes of death: ICD10	G46.4	Cerebellar stroke syndrome
40002	Contributory (secondary) causes of death: ICD10	G46.5	Pure motor lacunar syndrome
40002	Contributory (secondary) causes of death: ICD10	G46.6	Pure sensory lacunar syndrome
40002	Contributory (secondary) causes of death: ICD10	G46.7	Other lacunar syndromes
40002	Contributory (secondary) causes of death: ICD10	G46.8	Other vascular syndromes of brain in cerebrovascular diseases
40002	Contributory (secondary) causes of death: ICD10	I64	Stroke, not specified as haemorrhage or infarction
40002	Contributory (secondary) causes of death: ICD10	I69.4	Sequelae of stroke, not specified as haemorrhage or infarction
42040	GP clinical event records	14A7.00	H/O: CVA/stroke
42040	GP clinical event records	14A7.11	H/O: CVA
42040	GP clinical event records	14A7.12	H/O: stroke
42040	GP clinical event records	14AK.00	H/O: Stroke in last year
42040	GP clinical event records	1M4..00	Central post-stroke pain
42040	GP clinical event records	661M700	Stroke self-management plan agreed
42040	GP clinical event records	661N700	Stroke self-management plan review
42040	GP clinical event records	662e.00	Stroke/CVA annual review
42040	GP clinical event records	662e.11	Stroke annual review
42040	GP clinical event records	662M100	Stroke 6 month review
42040	GP clinical event records	662M200	Stroke initial post discharge review
42040	GP clinical event records	662M.00	Stroke monitoring
42040	GP clinical event records	7P24200	Delivery of rehabilitation for stroke
42040	GP clinical event records	8HHM.00	Ref to multidisciplinary stroke function improvement service
42040	GP clinical event records	8IEC.00	Ref multidisciplinary stroke function improvement declined
42040	GP clinical event records	9h21.00	Excepted from stroke quality indicators: Patient unsuitable
42040	GP clinical event records	9h22.00	Excepted from stroke quality indicators: Informed dissent
42040	GP clinical event records	9h2..00	Exception reporting: stroke quality indicators
42040	GP clinical event records	Fyu5600	[X]Other lacunar syndromes
42040	GP clinical event records	G663.00	Brain stem stroke syndrome
42040	GP clinical event records	G664.00	Cerebellar stroke syndrome
42040	GP clinical event records	G665.00	Pure motor lacunar syndrome
42040	GP clinical event records	G666.00	Pure sensory lacunar syndrome
42040	GP clinical event records	G667.00	Left sided CVA
42040	GP clinical event records	G668.00	Right sided CVA
42040	GP clinical event records	G66..00	Stroke and cerebrovascular accident unspecified
42040	GP clinical event records	G66..11	CVA unspecified
42040	GP clinical event records	G66..12	Stroke unspecified
42040	GP clinical event records	G66..13	CVA - Cerebrovascular accident unspecified
42040	GP clinical event records	G68X.00	Sequelae of stroke,not specfd as h’morrhage or infarction
42040	GP clinical event records	Gyu6C00	[X]Sequelae of stroke,not specfd as h’morrhage or infarction
42040	GP clinical event records	L440.11	CVA - cerebrovascular accident in the puerperium
42040	GP clinical event records	L440.12	Stroke in the puerperium
42040	GP clinical event records	ZV12511	[V]Personal history of stroke
42040	GP clinical event records	ZV12512	[V]Personal history of cerebrovascular accident (CVA)
42040	GP clinical event records	XaJ4O	Exception reporting: stroke quality indicators
42040	GP clinical event records	XE2te	H/O: CVA/stroke
42040	GP clinical event records	XaYbE	Stroke self-management plan agreed
42040	GP clinical event records	XaJ4b	Excepted from stroke quality indicators: Patient unsuitable
42040	GP clinical event records	XaJi5	Referral to multidisciplinary stroke function improvement service
42040	GP clinical event records	XE2aB	Stroke and cerebrovascular accident unspecified
42040	GP clinical event records	XE2aB	Stroke and cerebrovascular accident unspecified
42040	GP clinical event records	XE2aB	Stroke and cerebrovascular accident unspecified
42040	GP clinical event records	XaBL3	H/O: Stroke in last year
42040	GP clinical event records	XE2sl	Cerebrovascular disorders in the puerperium
42040	GP clinical event records	XaJ4c	Excepted from stroke quality indicators: Informed dissent
42040	GP clinical event records	XaIzF	Stroke/CVA annual review
42040	GP clinical event records	Xa0Ml	Central post-stroke pain
42040	GP clinical event records	XaR68	Stroke 6 month review
42040	GP clinical event records	XaYm4	Stroke initial post discharge review
42040	GP clinical event records	XaXlL	Referral for multidisciplinary stroke function improvement declined
42040	GP clinical event records	XaQbM	Pure sensory lacunar syndrome
42040	GP clinical event records	XaYZQ	Stroke self-management plan review
42040	GP clinical event records	XaLtA	Delivery of rehabilitation for stroke
42040	GP clinical event records	XaQbK	Pure motor lacunar syndrome